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17-DMAGHCI,98%

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Unit Price:

$700/G EXW

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CAS No.:

467214-21-7

Content:

98%

Packaging:

5g/bag

Price valid (until):

2026-08-16

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Cuicheng Biomedical Technology

Company Type:

Manufactory

Location:

China

Qualification:

Main Products:

Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

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Product Description
Seller Information

Description

1. Disrupting the Hsp90 Chaperone Mechanism

Like other ansamycin drugs, 17-DMAG binds competitively to the ATP-binding pocket located on the N-terminal domain of the Hsp90 protein.

Halting the Quality Control System: Hsp90 normally acts as a quality control chaperone, helping mutated or unstable oncogenic proteins fold correctly to prevent them from breaking down. Ubiquitin-Mediated Shredding: By blocking Hsp90's ATPase activity, 17-DMAG stops this protective folding. Unprotected client proteins become misfolded and are rapidly degraded via the ubiquitin-proteasome pathway.

2. Targeting Multiple Oncogenic Pathways

Because Hsp90 protects a wide variety of "client proteins" that drive cancer, 17-DMAG acts as a multi-targeted antineoplastic agent. It effectively downregulates:

Pro-Survival Kinases & Receptors: Destabilizes proteins like MET, Akt, HER2, and BCR-ABL.
Transcription and Cell Cycle Regulators: Suppresses critical cancer drivers, including NF-κB, Cyclin D1, and Survivin, leading to G2/M phase cell cycle arrest and early apoptosis (programmed cell death).
ROS Generation: Induces therapeutic stress in cancer cells by accelerating the production of Reactive Oxygen Species (ROS) while simultaneously suppressing their internal antioxidant enzymes.

3. Unique Molecular Target: NF-κB and IKK Depletion

A major functional distinction between 17-DMAG and 17-AAG is its effect on the nuclear factor-κB (NF-κB) network. 17-DMAG effectively depletes the subunits of IKK (IκB kinase). This strongly inhibits NF-κB DNA binding and downregulates anti-apoptotic genes, making it uniquely effective against hematological malignancies like Chronic Lymphocytic Leukemia (CLL).

4. Overcoming Multi-Drug Resistance

In biomedical research, 17-DMAG functions as a powerful tool to overcome stubborn treatment resistance:

Imatinib Resistance: It effectively bypasses resistance in chronic myeloid leukemia (CML) by completely destroying the mutated BCR-ABL protein instead of trying to block its mutated binding site.
Chemosensitization: It acts as a synergistic booster in animal xenograft studies when combined with chemotherapy or targeted monoclonal antibodies (such as Trastuzumab), reversing tumor tolerance.

Items	Specifications
storage condition	Store at -20
storage condition	≥26.2 mg/mL in DMSO; insoluble in EtOH; ≥3.04 mg/mL in H2O
color and appearance	Purple solid

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Basic Info

Product Name:

17-DMAG

Other Name:

17-DIMETHYLAMINOETHYLAMINO-17-DEMETHOXY-GELDANAMYCIN;17-DIMETHYLAMINOGELDANAMYCIN;Alvespimycin hydrochloride;BMS 826476;KOS 1022;AlvespiMycin hydrochloride(17-DMAG,BMS 826476;17-DMAG HCl (AlvespiMycin);17-DMAG (AlvespiMycin) HCl

CAS No.:

467214-21-7

Molecular Formula:

C32H48N4O8

InChIKeys:

DFSYBWLNYPEFJK-QBJGDBLXSA-N

Molecular Weight:

616.75

Exact Mass:

652.32400

NSC Number:

707545

DSSTox ID:

DTXSID40431773

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

174.00000

XLogP3:

3.89580

Storage Conditions:

Storeat-20

See More 17-DMAG Properties 

Hazard Identification

Classification of the substance or mixture

no data available

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	no data available
Signal word	no data available
Hazard statement(s)	no data available
Prevention	no data available
Response	no data available
Storage	no data available
Disposal	no data available

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More 17-DMAG Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

Location:
Chuangzhi valley,Chuangzhi Industrial Park ,Hanzhong Economic and Technological Dvelopment Zone,Hanzhong City, Shaanxi Province

Total Annual Revenue:
$2.5 million-$5 million

Total Employees:
51-100

Year of Establishment:
2019
Country Product Purchase Quantity Date Posted

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