SANA (MVD1, C₉H₇NO₅) is an experimental, first-in-class small molecule that stimulates creatine-dependent thermogenesis to promote weight loss. It is associated with CAS Number 42571-07-3 and PubChem CID 54133300.Chemical and Physical ProfileChemical Name: 2-hydroxy-5-(2-nitroethenyl)benzoic acid (Salicylic acid nitroalkene)Molecular Weight: 209.157 g⋅mol⁻¹Mechanism: Induces energy expenditure by targeting brown adipose tissue and activating energy-burning pathways independent of the classical uncoupling protein 1 (UCP1) mechanism.Scientific and Clinical StatusDeveloped by Eolo Pharma, the drug advanced to human clinical trials. Early research demonstrated the drug's potential as a novel obesity treatment by inducing weight loss in preclinical models, paving the way for further first-in-human studies.
SANA uses salicylate — the precursor of aspirin — as its scaffold, and a nitroalkene (nitroethenyl) group sits on the ring. That nitroalkene group is the feature that sets its pharmacology apart from the parent salicylate.Mechanism of ActionSANA works through a mechanism that sets it apart from conventional metabolic agents. In published research, it stimulated non-shivering thermogenesis in both brown and white adipose tissue. Notably, this effect did not depend on uncoupling protein 1 (UCP1) or on AMPK activation. Furthermore, depleting creatine abolished the effect entirely, which points to a creatine-dependent pathway. To test that link, researchers used mice lacking Ckmt1 (the gene for mitochondrial creatine kinase), and those animals showed impaired thermoregulation after treatment. As a result, SANA became the first small molecule reported to activate creatine-dependent thermogenesis — and it raised energy expenditure rather than suppressing appetite.Research BackgroundResearchers have studied SANA in both preclinical models and an early human trial. The findings below describe that published work; they are not claims about results in any individual.In rodent models, SANA reduced body weight and protected against diet-induced obesity, insulin resistance, high triglycerides, and liver steatosis. Moreover, it did so by boosting mitochondrial respiration and creatine-dependent energy expenditure. Interestingly, those same models preserved — and sometimes increased — lean muscle mass even as fat mass dropped. This contrasts with GLP-1 receptor agonists, which often drive a loss of lean mass.Building on those results, researchers then evaluated SANA (as MVD1) in a randomized, double-blind, placebo-controlled phase 1A/B first-in-human trial. The study paired a single-ascending-dose phase in healthy lean volunteers with a multiple-ascending-dose phase in volunteers with obesity, and it tracked safety, tolerability, pharmacokinetics, and early efficacy across a 15-day period. Nature Metabolism then published the results in 2025. Afterward, Eolo Pharma planned a larger phase 2 trial that will include patients with type 2 diabetes.Regulatory StatusSANA (MVD1) remains an investigational compound. Because it sits in early clinical development, it has no approved brand name and stays unavailable for commercial or prescription sale. No regulatory authority, including the FDA, has approved it for human use. Therefore, Kimera supplies it strictly for laboratory research — not for human or veterinary consumption. It also remains the proprietary lead candidate of Eolo Pharma, which is developing it for obesity, type 2 diabetes, and other cardiometabolic conditions.Handling, Storage & SolubilityAs a salicylate-class powder, SANA dissolves readily in organic solvents such as DMSO, so most labs prepare it as a DMSO stock for in-vitro work. Store it cold, desiccated, and away from light. As always, check the safety data sheet first, and follow standard practices for fine research powders.Analytical & QualityEvery batch we supply carries third-party COA verification, and independent analytical methods confirm its identity and purity. Because SANA has a well-defined structure (CAS 42571-07-3; PubChem CID 54133300) and a documented profile in the peer-reviewed literature, labs have clear reference points for confirming identity.Class Context: SANA vs. the Salicylate ScaffoldSANA derives from salicylate, yet its pharmacology diverges sharply from the parent compound. Salicylate can shift metabolism, but only at very high doses and mainly through AMPK. In contrast, SANA produced a far larger thermogenic effect and worked through a different, creatine-dependent route that needs neither AMPK nor UCP1. In short, the nitroalkene group redirects a familiar scaffold toward an entirely different metabolic pathway.Frequently Asked QuestionsWhat is SANA (MVD1)? An investigational nitroalkene derivative of salicylate, studied as a research tool for creatine-dependent thermogenesis and adipose-tissue metabolism.How does SANA work? It activates non-shivering thermogenesis in adipose tissue through a creatine-dependent pathway, and it does not rely on UCP1 or AMPK.Why is SANA also called MVD1? MVD1 is the clinical-development code that its developer, Eolo Pharma, assigned to it.Is SANA approved for human use? No. It is an early-stage investigational compound with no approved brand name, and DIDEU supplies it for laboratory research only.
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