—— Product Specifications ——

—— Product Detail ——

• • • • • • • • • • • • • • • • • • • • • • • Product Overview

                                              Fmoc-Cys(Trt)-OH is a protected cysteine derivative with the molecular formula C₃₇H₃₁NO₄S and a molecular weight of 585.71 g/mol. This white to off-white crystalline powder is a key building block for solid-phase peptide synthesis (SPPS), featuring the Fmoc (9-fluorenylmethyloxycarbonyl) protecting group on the amino group and the Trt (trityl) protecting group on the thiol side chain of L-cysteine. The orthogonal protection strategy allows for selective deprotection, with Fmoc removed under basic conditions and Trt under acidic conditions. This compound is essential for the synthesis of cysteine-containing peptides and proteins, enabling the formation of disulfide bonds and other post-translational modifications.

                                              Synthetic Process

                                              Fmoc-Cys(Trt)-OH is synthesized through the following routes:

                                              • Reaction of cysteine with trityl chloride: L-Cysteine is reacted with trityl chloride to protect the thiol group.

                                              • Fmoc protection: The resulting S-trityl-cysteine is reacted with Fmoc chloride or Fmoc-OSu in the presence of a base.

                                              • Purification: The crude product is purified by recrystallization or column chromatography.

                                              Mechanism of Action / Application Principles

                                              • Solid-Phase Peptide Synthesis: Serves as a building block for the incorporation of cysteine residues into peptide sequences.

                                              • Disulfide Bond Formation: The Trt group protects the thiol during synthesis and can be selectively removed to enable disulfide bond formation.

                                              • Protein Research: Used in the synthesis of cysteine-containing peptides and proteins.

                                              Quality Specifications

                                              
                                              

                                              
                                              

                                              Parameter	Specification
                                              Assay (HPLC)	≥98.0%
                                              Appearance	White to off-white crystalline powder
                                              Specific Rotation [α]²⁰/D	+8° to +12° (c=1, DMF)
                                              Loss on Drying	≤0.5%
                                              Residue on Ignition	≤0.1%

                                              Each batch is accompanied by a Certificate of Analysis (COA).

                                              Packaging & Storage

                                              • Research quantities: 1g, 5g HDPE bottles

                                              • Bulk quantities: 25g, 100g HDPE containers

                                              Storage conditions: Store in a cool, dry place in tightly sealed containers, protected from light. Under recommended conditions, shelf life is 24 months.

                                              
                                              

— C ompany Profile ——

Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.

Our company is committed to making every effort to provide ideal chemical products to potential customers worldwide, including but not limited to: organic/inorganic reagents, biological reagents, plant extracts, pharmaceutical intermediates, active pharmaceutical ingredients (APIs), reference standards, reference substances, peptides, and more. Meanwhile, we have established long-term and stable cooperative relationships with university laboratories and off-campus research institutions, enabling us to offer tailored product services based on customers' actual needs.

We currently support customized services for most product categories, with supply quantities ranging from milligram (mg), gram (g) to kilogram (kg) levels, as well as wholesale. Product purity covers the full spectrum from 90% to 99.9%, providing customers with one-stop convenient services.

To date, our products have been exported to developed countries such as the United States, Australia, Canada, Mexico, as well as EU member states including France, Germany, and many other countries and regions such as Nigeria, Ghana, Southeast Asia, and other parts of Asia. Our product quality and services have consistently received high praise.

Looking ahead, our company will continue to serve as a bridge connecting China and the world, delivering high-quality products and services to global customers.

—— Q&A ——

Q1: How to confirm the product quality before placing orders?
A: By sending you available samples. Or if you have special requirements for the goods, we can prepare samples according to your requirements for confirmation.

Q2: Can you supply free samples?
A: Yes, we can provide a free sample, but the shipping cost will be paid by the customers. You can either pay the shipping cost or arrange a courier to collect the samples.

Q3: How do you treat quality complaints?
A: All our products are strictly tested by our QC and confirmed by QA; unqualified material will not be released to customers. If any quality problem is confirmed to be caused by us, we will replace the goods or refund your payment immediately.

Q4: What is your MOQ? Is there a discount?
A: For highvalue products, our MOQ starts from 1g and generally starts from 10g. For other lowprice products, our MOQ starts from 100g and 1kg.
Q: Is there a discount?
A: Yes, for larger quantities, we always support with better prices.

Q5: How to start orders or make payments?
A: You can send us your Purchase Order (if your company has one), or just send a simple confirmation by email or via Trade Manager. We will then send you a Proforma Invoice with our bank details for your confirmation, and you can make payment accordingly. If you have other preferred payment methods, we are open to discussion and negotiation.