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Bulk Price Dihexa Peptides 99% Pure for Mental Clarity CAS 1401708-83-5 Factory Direct Sale

Name: Bulk Price Dihexa Peptides 99% Pure for Mental Clarity CAS 1401708-83-5 Factory Direct Sale
Brand: zwxs
SKU: pr2607202813
Price: 40 USD
Availability: InStock

TDS 178 Inquiries

Unit Price:

$40-41/MT FOB

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CAS No.:

1401708-83-5

Grade:

Pharmaceutical Grade

Content:

99%

Port:

Guangzhou

Brand:

zwxs

Packaging:

5mg/vial 10vials/box

Sample Available:

Yes

Price valid (until):

2027-08-31

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Jinan Zhiwenxinsheng Electric Technology Co., Ltd.

Company Type:

Trader

Location:

China

Payment Terms:

TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average Lead Time:

3 days

Qualification:

Main Products:

peptides

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Product Details
Seller Information
Inquiry History

Description

Product Detail

Name:Molly

email: zwxs5@zwxstech.com

whatsapp/wechat: 15100979596

Dihexa More Info

Dihexa is a synthetic peptide derived from angiotensin IV, designed primarily for neuropharmacological applications. It exhibits significant potential in treating neurodegenerative disorders such as Alzheimer's disease and cognitive impairments.

Mechanism of Action

Dihexa functions by mimicking and enhancing the effects of nerve growth factor (NGF), crucial for neuronal survival and function. It binds with high affinity to hepatocyte growth factor (HGF) and its receptor, c-Met, activating pathways that promote neural growth and repair. This interaction leads to increased synaptic plasticity and density, particularly in the hippocampus, which is vital for memory and learning processes . Dihexa's ability to cross the blood-brain barrier allows it to exert its effects directly within the central nervous system, a significant advantage over many therapeutic agents.

Applications

The primary applications of Dihexa include:
1. Cognitive Enhancement: Animal studies have shown that Dihexa can improve cognitive function and memory recovery in models simulating Alzheimer's disease.
2. Neuroprotection: It has demonstrated protective effects against neuronal apoptosis, suggesting potential use in various neurodegenerative diseases.
3. Synaptogenesis: Dihexa promotes the formation of new synapses, which is critical for restoring cognitive functions impaired by disease or injury.

Routes of Administration

Dihexa can be administered orally, which is notable for a peptide drug. Its formulation allows it to maintain metabolic stability and a prolonged half-life of approximately 12.68 days, enhancing its potential therapeutic efficacy

Safety and Side Effects

Initial safety studies indicate that Dihexa exhibits no apparent toxicity or neoplastic induction, even though c-Met is recognized as an oncogene. However, comprehensive human trials are still necessary to fully ascertain its safety profile . As a research compound, it is primarily intended for laboratory use, and its long-term effects in humans remain unstudied.

Items	Specifications
Product Name	Dihexa
CAS number	1401708-83-5
Purity	99%
Molecular Weight	504.66
Appearance	White powder
Molecular Formula	C27H44N4O5

Peptide Storage Guidelines: General Tips

When storing peptides, remember to:
• Store peptide in a cold, dry, dark place
• Avoid repeated freezing and thawing of peptide
• Avoid overexposure to the air
• Avoid light exposure
• Avoid storing peptides in solution long term
• Aliquot peptide according to experimental requirements

Our Company

Jinan Zhiwen Technology Co., Ltd.The company spirit of "customer first, integrity first principle, with a number of enterprises to establish long-term cooperative relations. Adhere to the quality of survival, creation and development, honest, trustworthy business philosophy, adhere to the "everything quality, customer satisfaction, new, people-oriented quality policy, and constantly improve and perfect themselves. To scientific management, advanced equipment, continuous innovation, to meet the needs of customers. Good reputation and high quality products, has been the majority of domestic and foreign merchants consistent trust. Won the trust of our customers and won the praise of customers!

Why Choose us ？

1. Higher quality products (>=99% purity) for most of peptides and raws. Quality Guaranteed: Many HPLC test reports are available .

2. Domestic warehouses and stocks: USA, Canada, Europe and Australia.

3. Ship worldwide with safe and secure lines: 100% delivery guaranteed. No worry about Customs issues.

4. Special Service: Drop-shipping if need.

5. Cheapest prices in the market, unbeatable！

6. Double-clearance express, safer and more efficient.

Payment and Packing

Advantage&shipping

RAQ

Q1: How to confirm the Product Quality before placing orders?
A: By sending you available samples. Or if you have special requirements for the goods, we can prepare samples according to your requirement for confirmation.
Q2: Can you supply free samples?
A: Yes, we can provide a free sample, but the shipping cost will be paid by the customers. You can either pay the shipping cost or arrange a courier to collect the samples.
Q3: How do you treat quality complaints?
A: All our products are strictly tested by our QC and confirmed by QA; unqualified material will not be released to customers. In case any quality problem is confirmed to be caused by us, we will replace the goods or refund your payment immediately.
Q4: What's your MOQ ?
A: For the high value product, our MOQ starts from 1g and generally starts from 10gs. For other low, price product, our MOQ starts from 100g and 1kg.
Q5: Is there a discount ?
A: Yes, for larger quantity, we always support with better price.
Q6: How to start orders or make payments ?
A: You can send our your Purchase order ( if your company has ), or just send a simple confirmation by email or by Trade Manager, and we will send you Proforma Invoice with our bank details for your confirmation, then you can make payment accordingly.

ECHEMI Editorial Reference

Dihexa is a synthetic peptide-based compound and angiotensin IV analog. As a research and pharmaceutical raw material, Dihexa is characterized by its defined molecular structure and peptide properties. It is primarily used for research, analytical testing, compound evaluation, and pharmaceutical development.

Certificates

Basic Info

Product Name:

Dihexa

Other Name:

L-Isoleucinamide,N-(1-oxohexyl)-L-tyrosyl-N-(6-amino-6-oxohexyl)-;N-(1-Oxohexyl)-L-tyrosyl-N-(6-amino-6-oxohexyl)-L-isoleucinamide;Dihexa;N-Hexanoic-Tyr-Ile-(6)aminohexanoic amide

CAS No.:

1401708-83-5

Molecular Formula:

C27H44N4O5

InChIKeys:

InChIKey=XEUVNVNAVKZSPT-JTJYXVOQSA-N

Molecular Weight:

504.7

Exact Mass:

504.66

Categories:

Bulk Drug Intermediates

Characteristics

Density:

1.111±0.06 g/cm3(Predicted)

Boiling Point:

866.2±65.0 °C(Predicted)

Research

Class:

Angiotensin IV-derived oligopeptide / HGF-c-Met potentiator

Status:

Research compound — Not FDA approved

Mechanism:

A synthetic, orally active, blood-brain-barrier-permeable oligopeptide (Hexanoyl-Tyr-Ile-Ahx-NH₂) derived from angiotensin IV. Dihexa binds hepatocyte growth factor (HGF) with high affinity (Kd = 65 pM) and allosterically potentiates HGF activity at its receptor c-Met, promoting dendritic spinogenesis and synaptogenesis. In preclinical models it was reported to be seven orders of magnitude more potent than BDNF at promoting synapse formation. Note: the foundational 2014 paper (McCoy AT, et al. Neurobiol Learn Mem. 2014) was retracted in 2025.

EC50 (HGF Binding KD):

65 pM

Activity note:

Dihexa is an HGF potentiator, not a direct receptor agonist. It does not activate c-Met alone but markedly augments HGF-induced c-Met activation at low nanomolar HGF concentrations. Functional synaptogenic activity was reported at 10⁻¹°–10⁻⁻ M (original data now subject to retraction).

Source:

Original report: McCoy AT, et al. Neurobiol Learn Mem. 2014;115:112-120 (retracted 2025). Benoist CC, et al. J Pharmacol Exp Ther. 2014;351(3):628-637.

Clinical Development:

NCT04488419

References

PubChem:

PubChem

UNII:

9WYX65A5C2

Literature:

Benoist CC, et al. J Pharmacol Exp Ther. 2014 — HGF/c-Met mechanism; McCoy AT, et al. Neurobiol Learn Mem. 2014 — Synaptogenesis data (Retracted 2025); Athira Pharma: Fosgonimeton (prodrug) pipeline status

Disclaimer:

Dihexa is NOT FDA-approved or EMA-approved as a medicine. It is a research compound only. The foundational 2014 paper describing its synaptogenic potency was retracted in 2025. Its phosphate prodrug fosgonimeton failed a Phase 2/3 Alzheimer’s trial (LIFT-AD, 2024). This listing is for industrial and laboratory research use only. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.

See More Dihexa Properties 

Seller Information

Business Type:
Trader

Main Products:
peptides

Location:
No. 41-9, Fenghuangshan Road, Beiyuan Street, Tianqiao District, Jinan City, Shandong Province

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
3 days

Total Annual Revenue:
$1 million-$2.5 million

Total Employees:
5-10

Year of Establishment:
2026

Jinan Zhiwen Technology Co., Ltd. is a professional manufacturer and supplier of pharmaceutical raw materials, peptide compounds and fine chemicals. We own standardized laboratories and complete quality inspection procedures, strictly testing every batch for purity and consistency. Our product portfolio covers hot‑sale peptide APIs, chemical intermediates for biomedical research. Serving clients worldwide, we provide custom synthesis, sample support, flexible order volumes and end‑to‑end supply‑chain solutions. Committed to quality‑first principle, we strive to become your long‑term and dependable partner for biochemical raw‑material procurement.

Payment Terms:

TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:

Peak season lead time: within 3 Workday; Off season lead time: within 1 Workday

Inquiry History

178 Inquiries

Country	Product	Purchase Quantity	Date Posted
Canada	Dihexa lyophilized 1401708-83-5	1	Aug 23, 2026
Canada	Dihexa 1401708-83-5	1 G	Mar 8, 2026
Bulgaria	Customized peptides high purity Dihexa with fast shipping door to door CAS 1401708-83-5	10 G	May 27, 2025
Australia	Dihexa	30 G	Oct 19, 2026
United States	Dihexa	500 G	Aug 19, 2026
United States	Dihexa	25 G	Jan 26, 2025
Russia	DIHEXA	50.00 G	Aug 14, 2024
Australia	Dihexa	2 G	Oct 19, 2026
United States	dihexa	10 MG	Sep 28, 2026
Spain	Dihexa	100 MG	Aug 30, 2026
United Arab Emirates	Diheza	1 G	Aug 28, 2026
Canada	Dihexa	130	Aug 12, 2026
Brazil	dihexa	90 MG	Aug 4, 2026
United States	Dihexa raw powder	10 G	Jul 26, 2026
Singapore	Dihexa	10 PCS	Jul 15, 2026
United States	Dihexa	1 G	Jul 11, 2026
Sweden	Dihexa	10 PCS	Jul 8, 2026
Australia	Dihexa	1 MT	Jul 2, 2026
United States	Dihexa	10 G	Jun 14, 2026
Germany	Dihexa	1 G	May 25, 2026

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