Complex Peptide,GHK-CU,Anti-Aging

I. Basic Characteristics of GHK CU

Copper peptide is unstable in acidic environments and releases copper ions, losing its efficacy. Therefore, it is generally not used in acidic cosmetics or should be used after an interval of time when used together with acidic cosmetics. It is prone to hydrolysis under oxidative conditions and can be stored for two weeks at 60°C in phosphate-buffered saline or in a pH 4.5-7.4 buffer solution. The partition coefficient in octanol-phosphate buffer salt water indicates that GHK-Cu is highly hydrophilic and is less stable in the presence of negatively charged lipids such as diacylphosphate. [2]
The copper peptide powder must be stored in a cool, dark, and clean place to ensure a minimum shelf life of at least 12 months. For long-term storage, it is recommended to store at 4°C, and the shelf life can be extended to at least 24 months.

II. Key Application Areas of Ghk cu

1. In the form of skin care products: CHK-Cu has multiple functions. It not only acts as a messenger but also serves as a carrier and transporter. Secondly, it has the advantages of being mild, non-irritating, and safe, making it highly valuable for application in external skin care products. 
(1) Anti-aging and wrinkle reduction effect: After copper peptides enter the skin, they release signals, inducing fibroblasts to become collagen and promoting collagen production. At the same time, they carry copper ions into the cells and release copper ions upon encountering enzymes, which are very important components in many enzymatic reactions. Researchers have conducted extensive studies on the anti-aging and wrinkle-reducing effects of copper peptides, and in vitro experiments have shown that its ability to stimulate the synthesis of collagen precursors is stronger than anti-aging components such as retinoic acid and vitamin C. However, the wrinkle-reduction effect is not as fast as that of AAs and requires continuous use for several months to feel the effect. Nevertheless, compared to AAs, there is relatively less research data on copper peptides, and most available data comes from the inventor Picket, lacking independent third-party verification.
(2) Promoting wound healing, repairing damaged skin, and improving skin density and toughness: Copper peptides can promote the growth, division, and differentiation of nerve cells and immune-related cells, effectively promoting wound healing and hair growth, and repairing damaged skin. For skin with minor trauma, damage, sensitivity, and fragility on the surface, using products containing copper peptides can have a repairing effect.
(3) Antioxidation: The antioxidant effect of blue copper peptide has been confirmed in vitro and animal experiments. It can block the formation of reactive oxygen species, remove various peroxides, protect keratinocytes from UV damage, and block free radicals from damaging the liver, protecting the liver. The excellent antioxidant effect of blue copper peptide can brighten the skin, make the skin smoother, and prevent skin aging.
(4) Usage and dosage: Skin repair peptide-1 is a product made of copper peptide powder. It can be added at the final stage of cosmetic production, with a preparation temperature below 40°C. The recommended concentration is 500ppm - 2,000ppm.
2. In the form of drug preparations or dietary supplements
GHK-Cu microspheres coated with hydroxypropyl cellulose are used as colon-targeted release drugs. The release of GHK-Cu is affected by the degree of cross-linking and the drug loading. This microsphere releases 50-80% of the drug within 4 hours. These studies suggest that GHK-Cu can be used as a dietary supplement.
Index table.

III.Main Efficacy