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Copper tripeptide

Copper tripeptide structure

CAS No:
89030-95-5
Formula:
C14H21CuN6O4
Chemical Name:
Copper tripeptide
Synonyms:
[N2-(N-Glycyl-L-histidyl)-L-lysinato(2-)]copper;Ghk-Cu/AHK-CU;Copper tripeptide (GHK-Cu);Prezatide copper,[N2-(N-Glycyl-L-histidyl)-L-lysinato(2-)]copper;tripeptide/GHK-Cu;Copper peptide, GHK-Cu, Copper tripeptide-1;GHK Copper;GHK.CU.HAC
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Copper Tripeptide is a tripeptide molecule rich in copper ions. Its sequence is GHK and it is widely present in human blood, saliva and urine. With age, the concentration of GHK gradually decreases, which is related to the decline of organ regeneration ability. Copper Tripeptide has strong antioxidant capacity, neutralizes free radicals, protects the skin from environmental damage, and with its unique copper ion affinity, it plays a role in promoting wound healing and activating skin regeneration.

Copper tripeptide, also known as [N2-(N-Glycyl-L-histidyl)-L-lysinato(2-)]copper or GHK-Cu, is a naturally occurring tripeptide. It was first isolated from human plasma but can be found in saliva and urine. During wound healing, it may be freed from existing extracellular proteins via proteolysis. Studies have shown that GHK-Cu has a maximal biological effect at 10-9mol/L and Its concentration in the body decreases with age[1].

Copper tripeptide Basic Attributes

Molecular Weight：

400.91

Exact Mass：

402.10800

EC Number：

1308068-626-2

Color/Form：

Light blue to blue

Characteristics

PSA：

186.03000

XLogP3：

1.04530

Critical Temperature & Pressure：

under inert gas (nitrogen or Argon) at 2–8 °C

Copper tripeptide Use and Manufacturing

Copper Tripeptide is commonly used in beauty, skin care and anti-wrinkle, and also has the effects of promoting hair growth and wound healing. As a powerful tissue protection and anti-inflammatory agent, Copper Tripeptide protects injured tissue from further damage by oxidation, sends out signals, migrates damaged proteins and scar tissue, and replaces them with normal tissue, promotes macrophages to be injected into the injured area, and releases growth proteins. Copper Tripeptide promotes the production of type I collagen, is suitable for anti-inflammatory and repair, promotes wound healing, reduces scars, promotes hair growth, and reduces hair loss; it can be used in skin care products to relieve wrinkles and improve skin elasticity.

Copper tripeptide (GHK-Cu) can be used as a skin antiaging agent. It could lead to the extracellular matrix accumulation increases in the rat wound model. Copper Peptide preparations were able to promote wound healing rates in diabetic ulcers and patients undergoing Mohs surgery. It could induce angiogenesis in rabbit models at 1012 mol/L by acting as a chemoattractant for capillary cells. It may also improve the autocrine growth factor milieu in keloid fibroblasts[1-2]. It can also be doped into It can also be doped into binary binary PBDB-T: ITIC to tune the crystallinity and phase separation of the active layer, improving the performance of polymer solar cells[3].

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