Good quality raw material Metoclopramide best price CAS 364-62-5
2 Inquiries
364-62-5
Pharmaceutical Grade
99%
hk
SHENGYUFAN INTERNATIONAL TRADING CO.,LTD.
KIT
2027-11-26
peptide
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Product Description
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Seller Information
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Inquiry History
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DescriptionECHEMI Editorial ReferenceMetoclopramide is a dopamine D2 antagonist that is used as an antiemetic.IC50 Value:Target: D2 ReceptorMetoclopramide is a dopamine receptor antagonist which has been used for treatment of a variety of gastrointestinal symptoms over the last thirty years. In various countries, metoclopramide is the antiemetic drug of choice in pregnant women. Findings provide reassurance regarding the safety of metoclopramide for the fetus when the drug is given to women to relieve nausea and vomiting du
Solid
Metoclopramide is a member of the class of benzamides resulting from the formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with the primary amino group of N,N-diethylethane-1,2-diamine. It has a role as an antiemetic, a dopaminergic antagonist, a gastrointestinal drug, a xenobiotic and an environmental contaminant. It is a tertiary amino compound, a substituted aniline, a member of benzamides and a member of monochlorobenzenes. It is a conjugate base of a metoclopramide(1+).|Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system. Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition to gastroesophageal reflux disease (GERD). It can also be used to prevent nausea or vomiting associated with chemotherapy or certain surgical or diagnostic procedures. One unique property of this drug is that it does not increase gastric acid secretion. It is available in the oral tablet form or in solution, and can also be administered through the intravenous route. Metoclopramide was initially approved by the FDA in 1980.|Metoclopramide is a Dopamine-2 Receptor Antagonist. The mechanism of action of metoclopramide is as a Dopamine D2 Antagonist.|Metoclopramide is an oral prokinetic and antiemetic agent used in the therapy of gastroesophageal reflux disease, gastroparesis and severe or chemotherapy induced nausea. Metoclopramide has been linked to rare instances of clinically apparent liver injury that are typically cholestatic and can be associated with bile duct loss.|Metoclopramide is a substituted benzamide and a derivative of para-aminobenzoic acid (PABA) that is structurally related to procainamide, with gastroprokinetic and antiemetic effects. Metoclopramide exerts its prokinetic effect by antagonizing dopamine mediated relaxation effect on gastrointestinal smooth muscle. This enhances the response of the gastrointestinal smooth muscle to cholinergic stimulation, thereby leading to an increase of gastric emptying into the intestines. Metoclopramide may also strengthen the lower esophagus sphincter, thereby preventing acid reflux. This agent antagonizes D2 dopamine receptors in chemoreceptive trigger zone (CTZ) of the medulla, thereby preventing nausea and vomiting.|A dopamine D2 antagonist that is used as an antiemetic.Basic Info-
Product Name:
Metoclopramide
Other Name:Benzamide,4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxy-;o-Anisamide,4-amino-5-chloro-N-[2-(diethylamino)ethyl]-;4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide;5-Chloro-2-methoxyprocainamide;N-(Diethylaminoethyl)-2-methoxy-4-amino-5-chlorbenzamide;N-(Diethylaminoethyl)-2-methoxy-4-amino-5-chlorobenzamide;Methochlopramide;2-Methoxy-5-chloroprocainamide;Metoclopramide;Plasil;Metochlopramide;N-(2-Diethylaminoethyl)-2-methoxy-4-amino-5-chlorobenzamide;N-[2-(Diethylamino)ethyl]-4-amino-5-chloro-2-methoxybenzamide;2-Methoxy-4-amino-5-chloro-N,N-dimethylaminoethylbenzamide;4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-o-anisamide;4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-o-anisamide;4-Amino-5-chloro-2-methoxy-N-(β-diethylaminoethyl)benzamide;DEL 1267;Reliveran;Moriperan;Metoclol;Primperan;Plasil (pharmaceutical);Parmid;Eucil;MCP-ratiopharm;Clopromate;Gastrosil;Meclopran;Gastro-tablinen;Maxeran;Draclamid;Metramid;Metamide;Gastrobid;Gastrese;Emperal;Gastromax;Regla;Gastro-Timelets;Gastrotem;Metocobil;Macperan;Orpamid;Afipran
CAS No.:364-62-5
Molecular Formula:C14H22ClN3O2
InChIKeys:InChIKey=TTWJBBZEZQICBI-UHFFFAOYSA-N
Molecular Weight:299.79638
Exact Mass:299.80
EC Number:206-662-9
UNII:L4YEB44I46
DSSTox ID:DTXSID6045169
NCI Thesaurus Code:C62046
ATC Code:A03FA01|A - Alimentary tract and metabolism
HScode:2924299090
Categories:
Characteristics-
PSA:
67.6
XLogP3:2.6
Appearance:Solid
Density:1.2±0.1 g/cm3
Melting Point:147.25 °C
Boiling Point:418.7°C at 760 mmHg
Flash Point:228.9±31.5 °C
Refractive Index:1.545
Water Solubility:Practically insoluble in water, sparingly soluble or slightly soluble in ethanol (96 per cent), slightly soluble in methylene chloride
Storage Conditions:2-8°C
Vapor Pressure:4.6X10-9 mm Hg at 25 deg C (est)
Toxicity:Oral-rat LD50:750 mg/kg; Oral-Mouse LD50:270mg/kg
Flammability characteristics:Flammable; burning produces toxic nitrogen oxides and chloride fumes
PKA:9.27None
Henrys Law Constant:Henry's Law constant = 8.7X10-17 atm-cu m/mol at 25 °C (est)
Dissociation Constants:9.27 |pka = 9.27
Collision Cross Section:173.2 Ų [M+H]+ [CCS Type: TW, Method: Major Mix IMS/Tof Calibration Kit (Waters)]|173.07 Ų [M+H]+
Experimental Properties:White crystalline powder; mp 182.5-184 °C. Soluble in water /Metoclopramide monohydrochloride monohydrate/|White crystalline, odorless; MW: 354.3; freely soluble in water /Metoclopramide hydrochloride/
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 4, Oral
Specific target organ toxicity â single exposure, Category 1
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H302 Harmful if swallowed
H370 Causes damage to organs
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
Response P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
P308+P316 IF exposed or concerned: Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Metoclopramide hydrochloride tablets, injection, and oral solution should be stored at controlled room temperature between 20-25 deg C. Metoclopramide hydrochloride tablets and metoclopramide hydrochloride oral solution should be stored in tight, light-resistant containers (ie, amber glass bottles).
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Seller Information
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Business Type:
Trader
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Main Products:
peptide
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Location:
Green Home, No. 1, Jianming South Road, Chang'an District, Shijiazhuang City, Hebei Province
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Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance
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Total Employees:
5-10
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Year of Establishment:
2025
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Inquiry History2 Inquiries
Country Product Purchase Quantity Date Posted 
France
Metoclopramide Hydrochloride 99% solid 364-62-5 powder
0.1 KG Sep 21, 2023 
United States
Metoclopramide
100 G Oct 29, 2023 Post an enquiry for this product
