Factory Supply 99% GHK-Cu Lyophilized Powder 50mg/Vial CAS 89030-95-5 Copper Tripeptide-1 Cosmetic Raw Material

• • • Basic Information:                                                          
  • 1、Chemical Nature: A stable chelate complex of GHK tripeptide and Cu²⁺, forming a five-membered chelate ring.
  • 2、CAS Numbers: 49557-75-7 (mainstream) / 89030-95-5 (alternate labeling).
  • 3、Appearance: Blue/purple powder; its aqueous solution shows a characteristic sky-blue color, with the color depth positively correlated with its concentration.
  • 4、Natural Occurrence: It exists naturally in human plasma, saliva, and urine. Its level is about 200 ng/mL at the age of 20, which drops to around 80 ng/mL by the age of 60—this decline is linked to reduced tissue regenerative capacity.
  • 5、Molecular Formula: C₁₄H₂₂CuN₆O₄.
  • 6、Molecular Weight: Approximately 401.91.

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  Core Mechanism of Action :                                          

  GHK-Cu acts as both a signaling peptide and a copper ion carrier, exerting dual biological effects through synergy between the GHK tripeptide and Cu²⁺:

  1、GHK Tripeptide: Regulates fibroblasts, promotes the synthesis of collagen and elastin, exerts anti-inflammatory and antioxidant effects, and modulates the expression of thousands of human genes related to cell regeneration and maintenance.

  2、Copper Ion (Cu²⁺): Serves as a cofactor for key enzymes such as lysyl oxidase (critical for collagen cross-linking) and superoxide dismutase (SOD, for antioxidant defense), participating in skin repair and metabolic processes.

  3、Synergistic Effect: The chelated structure allows the gentle release of copper ions, avoiding the toxicity of free copper, while enhancing skin permeability and the affinity of GHK for its receptors (100 times higher than free GHK).
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Applications：                                                                 

• 1、Anti-Aging: Stimulates the synthesis of type I/III collagen, elastin, and glycosaminoglycans, effectively firming the skin, reducing fine lines and deep wrinkles, and improving skin elasticity and density. Clinical studies show that 70% of women using GHK-Cu cream experienced improved collagen production, outperforming vitamin C (50%) and retinoic acid creams (40%).
• 2、Skin Barrier Repair: Accelerates epidermal cell regeneration, thickens the stratum corneum, relieves redness, dryness, and stinging caused by a damaged barrier, and is suitable for post-esthetic procedure repair (e.g., laser, microneedling, chemical peels).
• 3、Anti-Inflammatory & Antioxidant: Inhibits pro-inflammatory cytokines (such as TNF-α, IL-6) by suppressing the NF-κB and p38 MAPK signaling pathways, reduces skin inflammation, and scavenges free radicals to resist photoaging and dullness. Compared with free GHK, GHK-Cu has more significant anti-inflammatory and antioxidant effects.
• 4、Other Skincare Benefits: Refines pores, brightens skin tone, fades red acne marks, and promotes hair growth by increasing hair follicle size and thickness.

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• Product Specification:                                                    

Company Profile：                                                          

EnShi Technology Co., Ltd is a modern advanced enterprise specializing in production and exportation of APIs, Pharmaceutical intermediates, plant extracts etc. Our products are widely used in medicine, health care products, cosmetics, nutritional supplements and food additives areas. With years of experience in the pharmaceutical chemical and biosynthetic industries.It provides compliant, stable and cost-effective core raw materials as well as one-stop CDMO/CMO solutions for global pharmaceutical enterprises and innovative drug R&D institutions.