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raw material Nefiracetam

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Unit Price:

$600-700/KG FOB

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CAS No.:

77191-36-7

Grade:

Pharmaceutical Grade

Content:

99%

Port:

shanghai

Brand:

Hyper Chem

Packaging:

20kg/Drum 25kg/Drum

Price valid (until):

2026-09-04

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Hangzhou Hyper Chemicals Limited

Company Type:

Trader

Location:

China

Qualification:

Main Products:

Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

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Product Description
Seller Information
Inquiry History

Description

Name	Nefiracetam
CAS number	77191-36-7
Description	Nefiracetam is a synthetic nootropic research compound in the racetam family that has been extensively investigated for its neuropharmacological and cognitive effects in both in vitro and in vivo preclinical models. In vitro studies demonstrate that nefiracetam modulates cholinergic, glutamatergic, and GABAergic signaling, enhances voltage-gated calcium channel activity, and promotes neuronal plasticity through calcium-dependent intracellular pathways. In vivo, oral doses typically ranging from 1–30 mg/kg in rodents have been reported to improve learning and memory performance, reverse experimentally induced cognitive deficits, and enhance synaptic function in behavioral paradigms such as passive avoidance, maze navigation, and object recognition tasks. Additional preclinical studies suggest neuroprotective effects against ischemic, excitotoxic, and age-related neuronal injury, potentially through modulation of neurotransmitter release and intracellular signaling. These findings make nefiracetam a valuable research tool for investigating mechanisms underlying cognition, synaptic plasticity, neuroprotection, and age-associated neurological disorders.
Appearance	Solid powder
Quality Standard	USP, EP, BP, CP
Shipping Condition	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
Shelf Life	>2 years if stored properly
Sample package	Aluminium foil bag
Commercial package	Aluminium Tin, Fiber drum
Origin	China

Nefiracetam More Info

1. General Description

Nefiracetam is a synthetic nootropic compound belonging to the racetam family, developed by Daiichi Seiyaku (Japan) in the 1990s for the treatment of cerebrovascular disorders and cognitive impairment. It is a fat-soluble cognitive enhancer, also known under the trade name "TRANSlOn".

2. Chemical & Physical Properties

CAS Number: 77191-36-7

Molecular Formula: C₁₄H₁₉N₂O₂

Molecular Weight: 246.31 g/mol (246.3)

Chemical Name: N-(2,6-dimethylphenyl)-2-(2-oxopyrrolidin-1-yl)acetamide

Appearance: White to off-white powder

Purity: ≥97%

Solubility: Soluble in DMSO (50 mg/mL), soluble in water (5 mg/mL), soluble in ethanol

Half-life: 3–5 hours

Storage: Store powder at room temperature; protect from light and moisture

3. Mechanism of Action

Nefiracetam acts as a GABAergic, cholinergic, and monoaminergic neurotransmitter enhancer, targeting GABA receptors (GABAR agonist). Its mechanism involves multiple pathways:

Calcium channels: At 1 μM, increases the long-lasting component of calcium channel currents without affecting transient components.

Cholinergic modulation: At submicromolar concentrations (0.01–0.1 μM), induces short-term suppression of acetylcholine (ACh)-evoked currents; at micromolar concentrations (1–10 μM), produces long-term enhancement of ACh-evoked currents.

Protein kinase pathways: Interacts with PKA and PKC pathways.

BDNF expression: Promotes brain-derived neurotrophic factor (BDNF) expression.

Cerebral circulation: Improves cerebral blood circulation.

4. Indications & Pharmacological Effects

Nefiracetam is primarily used in research for conditions related to cognitive impairment:

Alzheimer's disease (investigational)

Learning and memory deficits

Cerebrovascular disorders and cognitive impairment

Used against Ro 5-4864-induced convulsions (experimental models)

Reported cognitive enhancement effects: improves memory, attention, and learning ability; anxiolytic and antidepressant effects

A 12-week clinical study (900 mg/day) showed reduced apathy in post-stroke patients

5. Dosage & Administration (Research Reference)

Typical research dosage range: 150–450 mg daily, divided into 3 doses

Maximum dose studied: up to 1200 mg/day

It is fat-soluble and should be taken with fatty foods for better absorption

Recommended to be used in combination with choline sources

6. Safety & Side Effects

Common side effects are generally mild and tend to occur at higher doses

Contraindicated in: renal insufficiency, urethral dysfunction, severe movement disorders, reduced gastric acid, pregnancy and lactation

Important note: Nefiracetam is classified as a research reagent only and is not approved for human therapeutic use in most countries; it is strictly for laboratory and scientific research purposes

7. Regulatory & Development Status

Currently in Phase II clinical studies

Historically used in Japan as a prescription drug; available as a supplement in the United States

Classified as a nootropic (cognitive enhancer) of the racetam family, considered more potent than Piracetam

8. Packaging & Quality

Common packaging: 1 kg/bag, 25 kg/drum

Quality documentation typically includes Certificate of Analysis (COA), HPLC, and NMR test reports

Shop raw material Nefiracetam-Detailed Image 1

Nefiracetam is a GABAergic, cholinergic, and monoaminergic neuronal systems enhancer for Ro 5-4864-induced convulsions.Target: GABA ReceptorNefiracetam induces a short-term depression of ACh-evoked currents at submicromolar concentrations (0.01-0.1 μM) and a long-term enhancement of the currents at micromolar concentrations (1-10 μM). Nefiracetam interacts with PKA and PKC pathways, which may explain a cellular mechanism for the action of cognition-enhancing agents. Lower (submicromolar)

Basic Info

Product Name:

Nefiracetam

Other Name:

1-Pyrrolidineacetamide,N-(2,6-dimethylphenyl)-2-oxo-;N-(2,6-Dimethylphenyl)-2-oxo-1-pyrrolidineacetamide;DM 9384;DMPPA;Nefiracetam;2-(2-Oxo-1-pyrrolidinyl)-N-(2,6-dimethylphenyl)acetamide;N-(2,6-Dimethylphenyl)-2-(2-oxo-1-pyrrolidinyl)acetamide;Translon;DZL 221;DMMPA

CAS No.:

77191-36-7

Molecular Formula:

C14H18N2O2

InChIKeys:

InChIKey=NGHTXZCKLWZPGK-UHFFFAOYSA-N

Molecular Weight:

246.3

Exact Mass:

246.30

EC Number:

1308068-626-2

UNII:

1JK12GX30N

NSC Number:

759830

DSSTox ID:

DTXSID2020923

HScode:

2933790090

Categories:

Nutrition Supplements

Characteristics

PSA:

49.4

XLogP3:

1.4

Appearance:

white to off-white

Density:

1.2±0.1 g/cm3

Melting Point:

153 °C

Boiling Point:

458.5°C at 760 mmHg

Flash Point:

231.1±25.4 °C

Refractive Index:

1.594

Water Solubility:

DMSO: >5mg/mL

Storage Conditions:

Store at RT

Toxicity:

LD50 in mice (mg/kg): 421 i.v.; 1766 orally (Betzing, 1982)

See More Nefiracetam Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 4, Oral

Eye irritation, Category 2

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H302 Harmful if swallowed H319 Causes serious eye irritation
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response	P301+P317 IF SWALLOWED: Get medical help. P330 Rinse mouth. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Storage	none
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Nefiracetam Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

Location:
Rm. 803, Tower 4, LOFT49 Creative City Pioneer Zone, No.88 Jiru Rd. Gongshu Dist., Hangzhou, 310015 ZJ, China

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$5 million-$10 million

Total Employees:
11-50

Year of Establishment:
2013

Certifications:
Certification Report by Bureau Veritas

About HyperChem

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to meet the needs of a diverse range of pharmaceutical cosmetics ingredients and nootropic supplements companies worldwide.

Our Competitiveness

One-stop supply

Wide Range Of products including pharmaceutical, Cosmetic Ingredients and nootropic supplements

Among all the pharmaceuticals,

90% of them with GMP certificates,

85% of them with DMF files and

50% of them passed FDA approval,

30% get CEP certificate

20% are new R&D products.

Custom Repackaging Service

We can efficiently repackage your material into sample sizes, custom batch-specific sizes, or semi-bulk package sizes according to your specifications. And ensures the product is packaged in a quality-controlled environment and will maintain its integrity throughout every stage of the process.

Quality Control/Quality Assurance

HyperChem is committed to delivering on its promises of top-quality products with verified quality data.

All materials are vigorously inspected by the factory and/or outsourced analytical laboratories to ensure each and every lot meets or exceeds our reference standards.

Trade assurance service with 100% payment protection, It is best achieved by delivering products and services 100% right the first time, on time, every time.

Professional

Transparent Communication

Fast Reaction,

Professional Suggestion

Beyond Expectation.

We have exclusive partnerships with research and production facilities across the country and we offer varied pharmaceutical services in the most cost-efficient way. The production facilities are GMP, WHO-GMP, EU GMP and US FDA approved and are backed by strong regulatory support such as Dossier, DMF, Tech Pack and relevant Stability studies for regulatory filings.

Inquiry History

3 Inquiries

Country	Product	Purchase Quantity	Date Posted
Lithuania	Nefiracetam	1000000 MG	Jul 20, 2026
United States	Nefiracetam	1	Aug 4, 2026
United States	Nefiracetam	20 G	Jun 5, 2026

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