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Hinokitiol499-44-5

Name: Hinokitiol499-44-5
Brand: OORENT
SKU: pr2608061060
Price: 33 USD
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CAS No.:

499-44-5

Grade:

Pharmaceutical Grade

Content:

99%

Port:

shanghai

Brand:

OORENT

Packaging:

vial

Price valid (until):

2026-09-06

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Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

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pharmaceutical intermediates,peptides,electronic chemicals

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Product Description
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Inquiry History

Description

Product Detail

Hinokitiol Basic information

Chemical Properties benefits Safety

Product Name:	Hinokitiol
Synonyms:	HINOKITIOL;BETA-THUJAPLICINE;B-THUJAPLICIN;2-HYDROXY-4-ISOPROPYL-2,4,6-CYCLOHEPTATRIEN-1-ONE;2-HYDROXY-4-ISOPROPYL-2,4,6-CYCLOHEPTATRIENE;2-hydroxy-6-isopropyl-cyclohepta-2,4,6-trien-1-one;2-hydroxy-6-propan-2-yl-cyclohepta-2,4,6-trien-1-one;2-hydroxy-6-propan-2-ylcyclohepta-2,4,6-trien-1-one
CAS:	499-44-5
MF:	C10H12O2
MW:	164.2
EINECS:	207-880-7
Product Categories:	Tropolones;Tropolones & Azulenes;499-44-5
Mol File:	499-44-5.mol

Hinokitiol Chemical Properties

Melting point	50-52 °C(lit.)
Boiling point	140 °C10 mm Hg(lit.)
density	1.0041 (rough estimate)
refractive index	1.5190 (estimate)
storage temp.	Sealed in dry,Room Temperature
solubility	Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
pka	7.06±0.30(Predicted)
form	solid
color	White
Odor	at 100.00 %. phenolic woody mossy
Odor Type	woody
Merck	14,9390
Stability:	Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 4 months.
Cosmetics Ingredients Functions	HAIR CONDITIONING ANTISTATIC
LogP	1.137 (est)
CAS DataBase Reference	499-44-5(CAS DataBase Reference)
NIST Chemistry Reference	2,4,6-Cycloheptatrien-1-one, 2-hydroxy-4-(1-methylethyl)-(499-44-5)
EPA Substance Registry System	2,4,6-Cycloheptatrien-1-one, 2-hydroxy-4-(1-methylethyl)- (499-44-5)

Safety Information

Hazard Codes	Xn
Risk Statements	22
Safety Statements	36
WGK Germany	3
RTECS	GU4200000
TSCA	TSCA listed
HS Code	2914290090

MSDS Information

Hinokitiol Usage And Synthesis

Chemical Properties	Hinokitiol is a tropolone derivative containing an unsaturated seven-membered carbon ring. It is a monoterpenoid – cyclohepta-2,4,6-trien-1-one substituted by a hydroxy group at position 2 and an isopropyl group at position 4. It is a enol and a cyclic ketone. It derives from a hydride of a cyclohepta-1,3,5-triene. Thujaplicins are soluble in organic solvents and aqueous buffers.Hinokitiol provides acetone on vigorous oxidation and gives the saturated monocyclic diol upon catalytic hydrogenation.It is stable to alkali and acids, forming salts or remaining unchanged, but does not convert to catechol derivatives. Hinokitiol, as other thujaplicins and tropolones, reversibly binds metal ions. It forms complex salts with metal ions.
benefits	Hinokitiol (β-thujaplicin) is a naturally occurring antioxidant, found in the heartwood of certain plants. It acts as a metal chelator and, also, enhances the activity of superoxide dismutase (Huang et al., 2015). It was found to be very protective in the assay. It has not been previously studied as a HC protectant. In addition to its antioxidant properties, hinokitiol has been shown to reduce inflammation via suppression of NFκB, and metalloproteinases, and to activate caspase 3. The former activities could contribute to its protective effect. Hinokitiol is a superpower ingredient that has anti-inflammatory, antioxidant, antibacterial, anti-fungal and anti-melanogenic properties. Best of all, hinokitiol is as gentle as it is powerful. Hinokitiol’s properties allow it to target the inflammatory redness and blemishes seen in rosacea and acne. Hinokitiol is effective against P. acnes bacteria, and there is no known acquired resistance to it, unlike other prescription antibiotics.
Safety	The safety of hinokitiol has been tested in rats and no carcinogenic effect to rats was found.In 2006, hinokitiol was categorized under the Domestic substances list (DSL) in Canada as non-persistent, non-bioaccumulative and non-toxic to aquatic organisms.
Description	Hinokitiol (β-thujaplicin) is a natural monoterpenoid found in the wood of trees in the family Cupressaceae. It is a tropolone derivative and one of the thujaplicins.Hinokitiol is used in oral and skin care products,and is a food additive used in Japan.
Uses	Antibacterial additive in foods, cosmetics, eye drops and toothpaste.
Uses	Hinokitiol is a natural monoterpenoid found in the wood of trees in the family Cupressaceae. It is a tropolone derivative and one of the thujaplicins. Hinokitiol has inhibitory effects on Chlamydia trachomatis and may be clinically useful as a topical drug.
Definition	ChEBI: A monoterpenoid that is cyclohepta-2,4,6-trien-1-one substituted by a hydroxy group at position 2 and an isopropyl group at position 4. Isolated from Thuja plicata and Chamaecyparis obtusa, it exhibits antimicrobial activities.
Anticancer Research	Studied in xenograft tumors such lung adenocarcinoma cell, EGFR-TKI-resistantlines PC9-IR and H1975 in which the growth inhibition was observed, a novel antitumormechanism was hypothesized. In summary, the hinokitiol can induce DNAdamage and autophagy (Rodrigues et al. 2015).
IC 50	DNMT1; Nrf2
References	[1] Y. IDO. Induction of apoptosis by hinokitiol, a potent iron chelator, in teratocarcinoma F9 cells is mediated through the activation of caspase-3[J]. Cell Proliferation, 2003, 32 1: 63-73. DOI:10.1046/j.1365-2184.1999.3210063.x [2] HIROSHI SUZUKI . Hinokitiol, a Selective Inhibitor of the Platelet-Type Isozyme of Arachidonate 12-Lipoxygenase[J]. Biochemical and biophysical research communications, 2000, 275 3: Pages 885-889. DOI:10.1006/bbrc.2000.3390 [3] YASUHIRO MORITA. The mechanism of the bactericidal activity of hinokitiol.[J]. Biocontrol science, 2007, 12 3: 101-110. DOI:10.4265/bio.12.101 [4] SHICHENG LIU Hitoshi Y. Hinokitiol, a metal chelator derived from natural plants, suppresses cell growth and disrupts androgen receptor signaling in prostate carcinoma cell lines[J]. Biochemical and biophysical research communications, 2006, 351 1: Pages 26-32. DOI:10.1016/j.bbrc.2006.09.166 [5] MYONG JIN LEE Eun G Y Jeong Won Kim. Hinokitiol activates the hypoxia-inducible factor (HIF) pathway through inhibition of HIF hydroxylases[J]. Biochemical and biophysical research communications, 2010, 396 2: Pages 370-375. DOI:10.1016/j.bbrc.2010.04.099

Hinokitiol Preparation Products And Raw materials

Raw materials

1,3-Cycloheptadiene,1-methoxy-6-(1-methylethyl)-(9CI)-->Boric acid, mono(1-methylethyl) ester-->2,4,6-Cycloheptatrien-1-one, 4-chloro-2-hydroxy--->beta-dolabrin-->3-Cycloheptene-1,2-dione,6-(1-methylethyl)-,(6S)-(9CI)-->2,4,6-Cycloheptatrien-1-one, 4-bromo-2-hydroxy--->2,4,6-Cycloheptatrien-1-one,2-amino-6-(1-methylethyl)-(9CI)-->Cycloheptanone, 3-(1-methylethyl)--->1,3,5-Cycloheptatriene, 1-methoxy-

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Hinokitiol is a component of essential oils isolated from Chymacyparis obtusa, reduces Nrf2 expression, and decreases DNMT1 and UHRF1 mRNA and protein expression, with anti-infective, anti-oxidative, and anti-tumor activities.

Basic Info

Product Name:

Hinokitiol

Other Name:

2,4,6-Cycloheptatrien-1-one,2-hydroxy-4-(1-methylethyl)-;2,4,6-Cycloheptatrien-1-one,2-hydroxy-4-isopropyl-;2-Hydroxy-4-(1-methylethyl)-2,4,6-cycloheptatrien-1-one;Hinokitiol;2-Hydroxy-4-isopropyl-2,4,6-cycloheptatrien-1-one;4-Isopropyltropolone;β-Thujaplicin;β-Thujaplicine;β-Isopropyltropolon;IPT;6-Isopropyltropolone;Hyka 1;S-HT;HT-SF;NSC 18804;Kisei Pro-Sol N;Hinokitiol S-HT;beta-Thujaplicin;beta-Thujaplicine;H 0142;2-Hydroxy-6-propan-2-ylcyclohepta-2,4,6-trien-1-one;2-Hydroxy-6-(propan-2-yl)cyclohepta-2,4,6-trien-1-one;2-Hydroxy-4-(propan-2-yl)cyclohepta-2,4,6-trien-1-one;772-41-8;333760-35-3;1411673-73-8

CAS No.:

499-44-5

Molecular Formula:

C10H12O2

InChIKeys:

InChIKey=FUWUEFKEXZQKKA-UHFFFAOYSA-N

Molecular Weight:

164.2

Exact Mass:

164.20

EC Number:

207-880-7

UNII:

U5335D6EBI

NSC Number:

18804

DSSTox ID:

DTXSID6043911

HScode:

2914400090

Categories:

Plant Extracts

Characteristics

PSA:

37.3

XLogP3:

2.1

Appearance:

Solid

Density:

1.21 g/cm³

Melting Point:

52-52.5 °C

Boiling Point:

140 °C10 mm Hg(lit.)

Flash Point:

128.1±18.5 °C

Refractive Index:

1.554

Water Solubility:

1.2 mg/mL at 25 °C

Vapor Pressure:

8.98E-05mmHg at 25°C

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Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 4, Oral

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H302 Harmful if swallowed
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product.
Response	P301+P317 IF SWALLOWED: Get medical help. P330 Rinse mouth.
Storage	none
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Hinokitiol Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

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We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
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Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

5 Inquiries

Country	Product	Purchase Quantity	Date Posted
China	Hinokitiol	20 KG	May 7, 2024
United States	hinokitiol	1 KG	Aug 6, 2026
Albania	Hinokitiol	2 KG	Apr 3, 2026
China	Hinokitiol	20 KG	Apr 26, 2024
India	Hinokitiol	100 KG	Jan 26, 2024

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