Semaglutide15mgSemaglutide High Purity Research Grade Lyophilized Peptide Powder

                                                                       WhatsApp: +85266976540

                                                                                          +85252797286                                                                                                           Smegglutide (CAS No. 910463-68-2) is a known long-acting GLP-1 receptor agonist peptide, with research codes NN-9535 and NNC0480-0389. As a chemically modified analog of natural glucagon-like peptide-1, this peptide has attracted widespread attention in peptide research laboratories, biochemical institutions, and pharmaceutical R&D organizations worldwide. It belongs to the class of bioactive synthetic peptides and is primarily supplied in lyophilized powder form for laboratory research. Smegglutide has the molecular formula C₁₈₇H₂₉₁N₄₅O₅₉ and a molecular weight of 4113.58 Da. Its InChIKey is DLSWIYLPEUIQAV-CCUURXOWSA-N, which can serve as a unique chemical identifier for database matching and material traceability on chemical and peptide platforms such as Echemi.

Pure smegglutide free base is physically a white to off-white lyophilized solid powder. Freeze-drying is crucial for this peptide product. Peptide molecules are typically sensitive to temperature, humidity, and ultraviolet light. Freeze-drying removes solvents under low-temperature, vacuum conditions, significantly slowing down degradation, peptide chain hydrolysis, and impurity formation during storage and transportation. Unfreeze-dried semaglutide aqueous solutions degrade rapidly, producing unknown related impurities and losing their bioactivity for research purposes. Therefore, commercially available research-grade semaglutide raw materials are almost exclusively supplied in freeze-dried powder form, rather than liquid solutions.

Our research-grade semaglutide strictly adheres to standardized peptide synthesis and purification procedures. The entire production process includes solid-phase peptide synthesis (SPPS), peptide chain cleavage, crude peptide precipitation, multi-step high-performance liquid chromatography purification, desalting, sterile filtration, and final freeze-drying. Solid-phase synthesis allows for the precise assembly of the amino acid sequence of this long-chain peptide molecule. After synthesis, the crude product contains truncated peptide fragments, deprotected byproducts, and residual reagents. These impurities are progressively removed using reversed-phase high-performance liquid chromatography (HPLC) to achieve the target high purity. The final product requires purity confirmation by HPLC, molecular weight verification by mass spectrometry (MS), and testing for moisture content, residual solvents, and appearance. Our smegglutinin typically achieves an HPLC purity of ≥98%, and higher purity (≥99%) products can be provided upon request. Each batch comes with a complete set of documentation, including a Certificate of Analysis (COA), HPLC chromatogram report, and MS data for user reference in laboratory records.

Proper storage conditions are crucial for maintaining the peptide integrity and bioactivity of smegglutinin (CAS 910463-68-2). Long-term storage is recommended at -20°C, in a sealed container, dry and protected from light. Repeated freeze-thaw cycles should be strictly avoided. After opening, dissolve the lyophilized powder in an aqueous solution; the prepared peptide solution should be used in experiments as soon as possible; remaining liquid should not be stored for extended periods. Humidity is another major risk factor. Moisture absorption can lead to peptide hydrolysis, increase the content of related impurities, and reduce experimental reproducibility. To minimize temperature fluctuations during international transport, cold chain transportation is recommended. Customers are advised to transfer the product to a -20°C refrigerator immediately after opening.

In the global research field, semaglutide, as a GLP-1 receptor agonist, is widely used in various preclinical research areas. The GLP-1 receptor is an important target in biochemical and pharmacological research. This synthetic peptide analog can bind to the GLP-1 receptor and activate downstream signaling pathways for laboratory observation and mechanism exploration. Its research applications include receptor-ligand interaction studies, cellular pharmacological analysis, peptide structure-activity relationship studies, peptide modification exploration, peptide pharmacokinetic modeling studies, and comparative studies of different GLP-1 analogs. Many research institutions purchase bulk or vial-sized lyophilized semaglutide powder for in vitro cell experiments and preclinical model studies. It can serve as a reference material for peptide pharmacology laboratory projects. It is important to emphasize repeatedly that the material we provide is a research peptide raw material, not a finished drug, and should not be used for clinical treatment.