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Liraglutide is a transparent, colorless solution. The dosage form is subcutaneous . After more than 10 years of research and development, Lilalutide has many functions such as promoting islet cell regeneration, reducing blood sugar, weight loss and protecting the cardiovascular system. The trade name  is used to treat type 2 diabetes, and the trade nameis used to treat chronic obesity as a supplement to diet control and physical training. Liraglutide is an acylated human glucagon like peptide-1 (GLP-1) receptor agonist with 97% amino acid sequence homology with endogenous human GLP-1 (7-37), retaining all the biological activity of GLP-1 and exhibiting GLP-1 receptor agonist activity. By expressing recombinant DNA in brewing yeast, its molecular structure differs from natural GLP-1 molecules by only one amino acid. The structure only modifies GLP-1 in two parts: the 34th lysine is replaced by arginine, and a glutamic acid mediated 16 carbon palmitoyl fatty acid side chain is added to the 26th lysine. The mechanism of action of liraglutide is similar to endogenous GLP-1, which binds and activates the GLP-1 receptor - a cell surface receptor Chemicalbook that can activate adenylate cyclase through excitatory G protein Gs coupling. Endogenous GLP-1 has a half-life of 1.5 to 2 minutes and is easily degraded by two widely present endogenous enzymes, dipeptidyl peptidase 4 (DPP-4) and neutral endonuclease (NEP). Compared to natural GLP-1, liraglutide is more stable, with a plasma half-life of 13 hours after subcutaneous administration. This half-life change is attributed to the modification of the structure of liraglutide. Due to the presence of fatty acid side chains, on the one hand, the hydrophobicity of palmitic acid self forms into a heptamer, slowing down the absorption at the subcutaneous site; On the other hand, after absorption into the bloodstream, it increases its binding with plasma albumin, forming a slow release reservoir that temporarily avoids contact with endogenous enzymes and slows down release, prolonging the absorption and distribution time in the body, and significantly prolonging the half-life compared to natural GLP-1. Drug interaction with liraglutide can cause delayed gastric emptying time, which may affect the absorption of oral medications taken simultaneously. In clinical pharmacology trials, liraglutide did not affect the absorption of the tested oral drug in terms of clinical relevance. Nevertheless, monitoring the potential consequences of delayed absorption of oral medications taken simultaneously

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Under ideal, controlled conditions, Adipotide once showed promising advantages:

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2. Potentially Fast-Acting:​ In monkey studies, significant body fat reduction was observed within weeks.

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Samaglutide Product Introduction

I. Basic Information
Name: Samaglutide
CAS No.: 910463-68-2
Molecular Formula: C₁₈₇H₂₉₁N₄₅O₅₉
Molecular Weight: 4113.58 Da
Structure: Long-acting GLP-1 receptor agonist, fatty acid modified, half-life approximately 7 days

Appearance: White lyophilized powder
Purity: ≥99% (HPLC-MS)

II. Mechanism of Action (GLP-1 monoreceptor agonist)
Glucose Control: Glucose-dependent insulinotropic effect, glucagon inhibition
Weight Loss: Delays gastric emptying, potent appetite suppression, reduces calorie intake
Cardiovascular Protection: Reduces the risk of major adverse cardiovascular events 

III. Core Efficacy
Weight Loss 
STEP 1: Average weight loss over 68 weeks 14–15% (approximately 15.5 kg)

Over 80% fat loss, muscle preservation

Blood sugar reduction 

Type 2 diabetes: HbA1c reduction of 1.5–2.0%

Improved metabolism

Benefits include lowering blood pressure, improving blood lipids, and reducing fatty liver

Cardiovascular benefits

SELECT trial: 20% reduction in MACE risk in overweight/obese individuals

Precautions for safe handling

Conditions for safe storage, including any incompatibilities