33 wt.% Solution in Glacial Acetic Acid | Strong Acid Brominating Reagent for Laboratory Synthesis

1. Product Overview

Bromine hydrogen acetic acid solution (CAS 37348-16-6) is a homogeneous mixture of hydrogen bromide dissolved in glacial acetic acid, typically at a concentration of 33% w/w. It serves as a highly active and stable source of anhydrous HBr, providing both strong acidity and nucleophilic bromide ions. This reagent is widely used in organic synthesis for introducing bromine atoms under non-aqueous conditions.

2. Key Features and Benefits

• Anhydrous Strong Acid: The acetic acid solvent enhances protonation capability compared to aqueous hydrobromic acid, making it effective for acid-catalyzed reactions.

• High Reactivity: Acts as a potent brominating agent for converting alcohols to alkyl bromides and facilitating olefin additions.

• Stability: More stable than gaseous HBr or aqueous solutions when handled under anhydrous conditions, allowing for precise stoichiometric control.

3. Major Applications

• Organic Synthesis: Used for the bromination of alcohols, ethers, and esters; promotes electrophilic addition to alkenes and alkynes to generate brominated intermediates.

• Pharmaceutical R&D: Employed in multi-step synthesis of pharmaceutical intermediates, including deprotection of benzyl ethers and N-benzylic groups.

• Catalysis: Serves as an acidic catalyst to accelerate esterification and etherification reactions in research settings.

4. Technical Specifications

5. Storage and Handling

Store in a cool, well-ventilated area at 2–8 °C. Use only corrosion-resistant containers such as glass or PTFE-lined vessels. Handle exclusively in a fume hood while wearing appropriate PPE (acid-resistant gloves, goggles, and lab coat). Quench excess reagent carefully with sodium carbonate or lime before disposal.

6. Safety Summary

• GHS Classification: GHS05 (Corrosive) – Danger

• Hazard Statements: H314 (Causes severe skin burns and eye damage), H335 (May cause respiratory irritation)

• Precautionary Statements: P260, P261, P264, P271, P280, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P310, P403+P233, P501

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