Dermorphin/ 99% Purity /5mg DR5/ Pain relief

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    Dermorphin is a natural heptapeptide isolated from the skin secretions of South American Amazonian tree frogs (such as Phyllomedusa sauvagei). As a potent natural opiate peptide, its name is a portmanteau of "derm" (skin) and "opiates."

• Chemical Structure: It is a heptapeptide with the amino acid sequence H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH₂. Its most notable structural feature is the presence of a D-alanine (D-Ala) residue, which is extremely rare in naturally occurring peptides synthesized by animal cells.
• Molecular Formula: C₄₀H₅₀N₈O₁₀
• Molecular Weight: Approximately 802.87 g/mol
• CAS Number: 77614-16-5
• Appearance: White to off-white solid powder
• Solubility: Soluble in DMSO; has low solubility in water (<1 mg/mL)

• Ultra-potent Analgesic Activity: It binds to μ-opiate receptors with extremely high affinity. In animal models, its analgesic potency is 30 to 40 times, and even up to 670 times (depending on the test model) that of opiates, with a longer duration of action.
• Lower Tolerance and Dependence: Compared to traditional opiates (such as opiates), Dermorphin induces significantly lower levels of drug tolerance and physical dependence.
• Blood-Brain Barrier Penetration: The peptide can significantly cross the blood-brain barrier, exerting powerful analgesic effects within the central nervous system.
• Resistance to Enzymatic Degradation: Due to the presence of a D-amino acid, Dermorphin is highly resistant to degradation by endogenous proteases, which confers upon it a longer half-life in the body.

• Postoperative Pain and Palliative Care Research: Early clinical trials have shown that when administered via intrathecal administration, Dermorphin demonstrates superior efficacy to opiates in alleviating postoperative pain syndromes. The scientific community is currently advocating for a re-evaluation of its potential applications in postoperative analgesia and palliative care for terminal patients.
• Development of Non-invasive Analgesics: Researchers are synthesizing linear and cyclic analogues of Dermorphin (such as chimeric peptides incorporating a 2,5-DKP scaffold) to explore their analgesic effects via non-invasive routes like intranasal or oral administration, aiming to develop novel pain relievers.
• Molecular Mechanism Studies of Opiate Receptors: Due to its extremely high specificity, high affinity, and minimal non-specific binding to μ-opiate receptors, Dermorphin is frequently used as a radioligand (e.g., [³H]dermorphin) to study opiate receptor binding characteristics, receptor distribution, and molecular conformation determinants.

      The core principle for storing parenteral lyophilized powder is strict refrigeration and absolutely no freezing. Before reconstitution, it is generally stored in the dark at 2 to 8°C. Once mixed and dissolved with the solvent, it must be used within a very short period.

Before Reconstitution (Original Packaging)

Strict Refrigeration: The vast majority of parenteral lyophilized powders need to be stored in a refrigerator at 2 to 8°C.

Absolutely No Freezing: Freezing will cause irreversible damage to the structure of proteins and peptides.

Protection from Light and Moisture: The product must be kept in its original packaging to avoid direct sunlight and accidental exposure to moisture.

After Reconstitution (Mixed State)

Highly Time-Sensitive: Once the lyophilized powder is dissolved with a sterile solvent, the stability of the drug drops significantly. It usually needs to be administered immediately or within a very short window (e.g., a few hours).

No Prolonged Storage: Under no circumstances should the reconstituted solution be stored in the refrigerator for use the next day. This can easily lead to loss of efficacy or severe bacterial contamination.

 * We will ship your order within 24–48 hours after payment is received.

 * We have dedicated shipping routes, allowing us to select the fastest and safest carrier for your specific destination—including FedEx, UPS, China Post, and other international express services. The estimated delivery time is approximately 7–15 business days.

 * We will also track the logistics throughout the entire process and update the logistics information for buyers in real time.

          Our company is located in Zhejiang Province and is a Chinese enterprise specializing in the production of peptide products.We are not intermediaries or resellers; we are the original manufacturer. This allows us to offer you the most competitive pricing. Our motto is: to manufacture products with care and serve customers with dedication.We are dedicated to serving every visitor with heart. No matter where you come from, you will experience our premium VIP service. We guarantee that every customer receives only the finest products, backed by exceptional after-sales support, as we strive to ensure your complete satisfaction.

1. What's the payment methods?
We could accept pay through Alipay, USDT, BTC and TT.

2.Does the product have a test report?
Each batch of our products undergoes testing before leaving the factory, and a Certificate of Analysis (COA) report is issued.

3.Can customers customize their own labels?

Custom labeling services are available. Please contact us to discuss your specific requirements prior to placing an order.

4.What is the product's shelf life?

When unopened, our products have a shelf life of two years under both room temperature and frozen storage conditions. Therefore, you can rest assured that extended shipping times will not cause the product to expire or degrade.

1.  * Ultra-High Purity Guaranteed
   Every batch is synthesized and purified to >99% purity, delivering the reliability and reproducibility your sensitive experiments demand.
2.  * Precision Dosing & Batch Consistency
   Peptides are accurately weighed and vacuum-sealed under sterile conditions. We enforce rigorous quality control to ensure unwavering consistency from batch to batch.
3.  * Endotoxin-Free & Sterile Assurance
   Produced in a certified cleanroom, our peptides are rigorously tested to be free of endotoxins, microbes, and impurities—safeguarding the integrity of your cell-based and in vivo studies.