DSIP / 99% Purity / 5mg DS5 / Delta Sleep Inducing Peptide

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Delta Sleep Inducing Peptide (DSIP) is a naturally occurring neuropeptide. It was first isolated in 1974 by Swiss scientists from the cerebral venous blood of sleeping rabbits. It was named for its ability to induce delta waves (deep sleep) in mammals. Below is a detailed explanation of the properties and effects of DSIP:

I. Basic Properties of DSIP

1. Chemical Structure and Physicochemical Characteristics:

• Amino Acid Sequence: DSIP is a nonapeptide (a peptide consisting of nine amino acids) with the sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu (single-letter code: WAGGDASGE).
• Molecular Weight and Formula: The molecular weight is approximately 848.82 Da, and the molecular formula is C₃₅H₄₈N₁₀O₁₅.
• Physical Form: It typically appears as a white to off-white powder. It has good water solubility (soluble in water at 0.5 mg/ml) and should be stored at -20°C.

2. In Vivo Distribution:
DSIP is widely distributed in mammals, including the brain (hypothalamus, limbic system), pituitary gland, peripheral organs, tissues, as well as in plasma and cerebrospinal fluid.

II. Main Effects and Potential Benefits of DSIP

DSIP acts as a "multifunctional" agent in the body. Beyond its core sleep-regulating function, It is also involved in neuroendocrine regulation and stress-alleviating mechanisms:

1. Sleep Architecture Regulation (Core Function):

• Promoting Deep Sleep: DSIP can increase slow-wave (delta wave) and spindle wave activity in electroencephalograms (EEG), shorten sleep onset latency, and improve sleep continuity.
• Normalization of Sleep Architecture: Unlike the "sedative" effect of traditional sleeping pills, DSIP primarily normalizes sleep rhythms rather than acting as a simple forced hypnotic.

2. Stress-alleviating and Mood Regulation:

• HPA Axis Modulation: DSIP regulates the hypothalamic-pituitary-adrenal (HPA) axis and modulates the production of stress hormones such as cortisol, thereby helping the body relieve pressure and resist acute and chronic stress responses.
• Neurotransmitter Modulation: It also influences the levels of neurotransmitters in the brain, such as serotonin (5-HT) and dopamine, offering potential benefits for improving mood and mental health.

3. Neuroprotection and Antioxidant Effects:

• Membrane Protection: Under stress conditions, DSIP can stabilize neuronal mitochondrial and lysosomal membranes, preventing structural damage.
• Antioxidant Activity: It inhibits excessive free radical production and alleviates cellular oxidative damage, demonstrating neuroprotective potential in ischemia-reperfusion injury models.

4. Endocrine and Metabolic Regulation:
DSIP can stimulate or regulate the release of various hormones, including luteinizing hormone (LH), growth hormone (GH), and adrenocorticotropic hormone (ACTH).

5. Withdrawal Assistance and Pain Management:

• Studies have shown that DSIP can alleviate withdrawal symptoms associated with opioid (e.g., morphine) and alcohol dependence, reducing withdrawal-related discomfort.
• It has also been found to alleviate chronic pain and help regulate blood pressure.

III. ⚠️ Important Safety and Research Status Warnings

Although DSIP has demonstrated various potentials in laboratory and early clinical research, the following points must be noted regarding its use and understanding:

• Unapproved Drug Status: Currently, DSIP has not been approved by any regulatory agency as a clinical therapeutic drug. It primarily exists as a "research chemical," and the quality and purity of products on the market vary widely.
• Limited Clinical Evidence: While early small-scale human trials showed it could improve sleep, subsequent research results have been contradictory and heterogeneous. The medical community still lacks a unified consensus on DSIP's exact mechanisms of action, optimal dosages, and administration routes.
• Contraindicated Populations: Pregnant and breastfeeding women, minors, and individuals with epilepsy, severe mental illnesses, or those currently using sedatives/opioids should strictly avoid using it without professional medical supervision.

      The core principle for storing parenteral lyophilized powder is strict refrigeration and absolutely no freezing. Before reconstitution, it is generally stored in the dark at 2 to 8°C. Once mixed and dissolved with the solvent, it must be used within a very short period.

Before Reconstitution (Original Packaging)

Strict Refrigeration: The vast majority of parenteral lyophilized powders need to be stored in a refrigerator at 2 to 8°C.

Absolutely No Freezing: Freezing will cause irreversible damage to the structure of proteins and peptides.

Protection from Light and Moisture: The product must be kept in its original packaging to avoid direct sunlight and accidental exposure to moisture.

After Reconstitution (Mixed State)

Highly Time-Sensitive: Once the lyophilized powder is dissolved with a sterile solvent, the stability of the drug drops significantly. It usually needs to be administered immediately or within a very short window (e.g., a few hours).

No Prolonged Storage: Under no circumstances should the reconstituted solution be stored in the refrigerator for use the next day. This can easily lead to loss of efficacy or severe bacterial contamination.

      * We will ship your order within 24–48 hours after payment is received.

     * We have dedicated shipping routes, allowing us to select the fastest and safest carrier for your specific destination—including FedEx, UPS, China Post, and other international express services. The estimated delivery time is approximately 7–15 business days.

     * We will also track the logistics throughout the entire process and update the logistics information for buyers in real time.

          Our company is located in Zhejiang Province and is a Chinese enterprise specializing in the production of peptide products.We are not intermediaries or resellers; we are the original manufacturer. This allows us to offer you the most competitive pricing. Our motto is: to manufacture products with care and serve customers with dedication.We are dedicated to serving every visitor with heart. No matter where you come from, you will experience our premium VIP service. We guarantee that every customer receives only the finest products, backed by exceptional after-sales support, as we strive to ensure your complete satisfaction.

1. What's the payment methods?
We could accept pay through Alipay, USDT, BTC and TT.

2.Does the product have a test report?
Each batch of our products undergoes testing before leaving the factory, and a Certificate of Analysis (COA) report is issued.

3.Can customers customize their own labels?

Custom labeling services are available. Please contact us to discuss your specific requirements prior to placing an order.

4.What is the product's shelf life?

When unopened, our products have a shelf life of two years under both room temperature and frozen storage conditions. Therefore, you can rest assured that extended shipping times will not cause the product to expire or degrade.

1.  * Ultra-High Purity Guaranteed
   Every batch is synthesized and purified to >99% purity, delivering the reliability and reproducibility your sensitive experiments demand.
2.  
3. * Precision Dosing & Batch Consistency
   Peptides are accurately weighed and vacuum-sealed under sterile conditions. We enforce rigorous quality control to ensure unwavering consistency from batch to batch.
4.  
5. * Endotoxin-Free & Sterile Assurance
   Produced in a certified cleanroom, our peptides are rigorously tested to be free of endotoxins, microbes, and impurities—safeguarding the integrity of your cell-based and in vivo studies.