Alprostadil/ 99% purity/ 20mcg PRO20/ Vasodilator/ Treatment of Erectile Dysfunction

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•          Alprostadil (also known as Prostaglandin E1, or PGE1) is a synthetic small-molecule drug with a chemical structure completely identical to the naturally occurring prostaglandin E1 in the human body. It belongs to the prostaglandin class of drugs and exhibits a wide range of biological activities.
  Below is a detailed elaboration of the physical properties, chemical properties, and pharmacological effects of Alprostadil:

  I. Physical Properties

  • Appearance: At room temperature, it typically presents as a white to slightly yellowish-white crystalline or solid powder.
  • Melting Point: Its melting point generally ranges between 110°C and 116°C.
  • Solubility: It is sparingly soluble in water. At 35°C, its solubility in water is approximately 8,000 micrograms per 100 milliliters. It is readily soluble in organic solvents.
  • Stability: It is thermolabile and photosensitive. In clinical formulations (such as lyophilized powder), it must be stored under refrigeration and protected from light to ensure its stability.

  II. Chemical Properties

  • Molecular Formula: C₂₀H₃₄O₅.
  • Molecular Weight: Approximately 354.49 g/mol (for its sodium salt form, the molecular weight is approximately 376.5 g/mol due to the addition of a sodium ion).
  • Chemical Structure: Its chemical name is (11α,13E,15S)-11,15-dihydroxy-9-oxoprosta-13-en-1-oic acid.  These functional groups collectively determine its solubility and pharmacological activity.
  • CAS Number: 745-65-3.

  III. Pharmacological Effects and Clinical Applications

  Alprostadil is a potent vasodilator and platelet aggregation inhibitor. Its mechanisms of action and clinical applications are primarily reflected in the following aspects:
  1. Mechanism of Action
  • Smooth Muscle Relaxation and Vasodilation: Alprostadil binds to prostaglandin receptors on the cell surface, activating adenylate cyclase and promoting an increase in intracellular cyclic adenosine monophosphate (cAMP) levels. This leads to a decrease in intracellular calcium concentration, which directly induces the relaxation of vascular smooth muscle and penile cavernosal smooth muscle, thereby increasing local arterial blood flow.
  • Inhibition of Platelet Aggregation: By elevating cAMP levels within platelets, it inhibits platelet activation and aggregation, improving hemorheology and microcirculation.
  • Extremely Short Half-Life: Upon entering the bloodstream, up to 80% of Alprostadil is rapidly metabolized during a single pass through the pulmonary circulation (primarily via β- and ω-oxidation), and the metabolites are excreted via the kidneys. This rapid metabolism allows it to exert local effects while significantly reducing systemic adverse reactions.
  2. Core Clinical Applications
  • Erectile Dysfunction (ED): As a second-line treatment, it is suitable for patients who are unresponsive to or intolerant of oral PDE5 inhibitors. It can be administered via intracavernosal  to directly induce smooth muscle relaxation and veno-occlusive mechanisms, thereby initiating and maintaining an erection.
  • Congenital Heart Disease in Newborns: It is used in newborns with ductal-dependent congenital heart diseases (such as pulmonary atresia, Tetralogy of Fallot, etc.). Through continuous intravenous infusion, it prevents or reverses the physiological closure of the ductus arteriosus, maintaining pulmonary or systemic blood flow and buying time for subsequent surgical interventions.
  • Improvement of Microcirculation Disorders: In certain countries, it is widely used to treat limb ulcers and rest pain caused by chronic arterial occlusive diseases (such as thromboangiitis obliterans and obliterative arteriosclerosis), as well as for antithrombotic therapy following organ transplantation.

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      The core principle for storing parenteral lyophilized powder is strict refrigeration and absolutely no freezing. Before reconstitution, it is generally stored in the dark at 2 to 8°C. Once mixed and dissolved with the solvent, it must be used within a very short period.

Before Reconstitution (Original Packaging)

Strict Refrigeration: The vast majority of parenteral lyophilized powders need to be stored in a refrigerator at 2 to 8°C.

Absolutely No Freezing: Freezing will cause irreversible damage to the structure of proteins and peptides.

Protection from Light and Moisture: The product must be kept in its original packaging to avoid direct sunlight and accidental exposure to moisture.

After Reconstitution (Mixed State)

Highly Time-Sensitive: Once the lyophilized powder is dissolved with a sterile solvent, the stability of the drug drops significantly. It usually needs to be administered immediately or within a very short window (e.g., a few hours).

No Prolonged Storage: Under no circumstances should the reconstituted solution be stored in the refrigerator for use the next day. This can easily lead to loss of efficacy or severe bacterial contamination.

* We will ship your order within 24–48 hours after payment is received.

      * We have dedicated shipping routes, allowing us to select the fastest and safest carrier for your specific destination—including FedEx, UPS, China Post, and other international express services. The estimated delivery time is approximately 7–15 business days.

     * We will also track the logistics throughout the entire process and update the logistics information for buyers in real time.

          Our company is located in Zhejiang Province and is a Chinese enterprise specializing in the production of peptide products.We are not intermediaries or resellers; we are the original manufacturer. This allows us to offer you the most competitive pricing. Our motto is: to manufacture products with care and serve customers with dedication.We are dedicated to serving every visitor with heart. No matter where you come from, you will experience our premium VIP service. We guarantee that every customer receives only the finest products, backed by exceptional after-sales support, as we strive to ensure your complete satisfaction.

1. What's the payment methods?
We could accept pay through Alipay, USDT, BTC and TT.

2.Does the product have a test report?
Each batch of our products undergoes testing before leaving the factory, and a Certificate of Analysis (COA) report is issued.

3.Can customers customize their own labels?

Custom labeling services are available. Please contact us to discuss your specific requirements prior to placing an order.

4.What is the product's shelf life?

When unopened, our products have a shelf life of two years under both room temperature and frozen storage conditions. Therefore, you can rest assured that extended shipping times will not cause the product to expire or degrade.

1.  * Ultra-High Purity Guaranteed
   Every batch is synthesized and purified to >99% purity, delivering the reliability and reproducibility your sensitive experiments demand.
2.  
3. * Precision Dosing & Batch Consistency
   Peptides are accurately weighed and vacuum-sealed under sterile conditions. We enforce rigorous quality control to ensure unwavering consistency from batch to batch.
4.  
5. * Endotoxin-Free & Sterile Assurance
   Produced in a certified cleanroom, our peptides are rigorously tested to be free of endotoxins, microbes, and impurities—safeguarding the integrity of your cell-based and in vivo studies.