Product Overview
Tirzepatide, with CAS registry number 2023788-19-2, is a long-chain synthetic polypeptide compound independently developed for biochemical and preclinical research scenarios. The molecular formula of this compound is C₂₂₅H₃₄₈N₄₈O₆₈, and the corresponding molecular weight is calculated at 4812.46 Da. The finished raw material exists as white or off-white crystalline powder under normal ambient temperature and airtight storage conditions. The compound exhibits favorable water solubility and can be dissolved in aqueous medium and dilute acidic solution environments, while its solubility performance declines significantly under high alkaline conditions. This peptide molecule functions as a dual agonist targeting GLP-1 receptor and GIP receptor, which makes it a core research material for global laboratories conducting explorations on energy metabolism regulation, glucose metabolism mechanism research, endocrine signal pathway analysis and related biochemical fundamental research.
Different from many short-chain peptide raw materials on the market, Tirzepatide adopts standardized solid-phase peptide synthesis (SPPS) production process. Each production link is equipped with continuous monitoring and sampling inspection procedures. After crude peptide synthesis, the product undergoes multi-step purification including preparative high-performance liquid chromatography, solvent desalination, vacuum freeze-drying and fine screening. The whole production workflow strictly follows standardized laboratory raw material manufacturing specifications to guarantee stable molecular structure, controllable impurity content and consistent performance among different production batches. All finished raw powder products are supplied in solid powder form without any auxiliary solvent, pre-mixed medium or other additives. Buyers can carry out secondary dissolution, solution preparation and formulation configuration according to their own experimental schemes and research objectives.
The target customer groups of Tirzepatide research-grade raw powder cover universities, biochemistry research institutes, biotechnology laboratories, pharmaceutical research and development enterprises, biochemical analytical laboratories and peptide engineering research teams distributed worldwide. The product is designed exclusively for laboratory scientific research, academic experimental projects, biochemical mechanism exploration and preclinical basic research work. This raw material is not suitable for direct human contact, ingestion or any application related to clinical therapy. All purchasers must clearly understand the usage limitation before placing orders, and comply with local biochemical reagent management regulations and laboratory operation standards in the region where the research work is carried out.
Detailed Product Specifications
Standard Name: Tirzepatide
CAS Number: 2023788-19-2
Molecular Formula: C₂₂₅H₃₄₈N₄₈O₆₈
Molecular Weight: 4812.46 Da
Appearance: White to off-white crystalline powder
Purity Standard: ≥98.0% (Tested by HPLC, High Performance Liquid Chromatography)
Detection Wavelength for HPLC Test: 220 nm
Solubility Property: Soluble in purified water, dilute acidic solution; slightly soluble in organic solvents; insoluble in alkane solvents
Amino Acid Sequence: Complete sequence confirmed by mass spectrometry (MS) verification
Moisture Content: ≤5.0% (Karl Fischer titration method)
Residual Solvents: Compliant with research-grade peptide raw material control limits
Single Unknown Impurity: ≤0.5%
Total Impurity Content: ≤2.0%
Heavy Metal Index: Lead ≤10 ppm, Cadmium ≤5 ppm, Mercury ≤1 ppm, Arsenic ≤2 ppm
Microbial Limit: Total aerobic microbial count ≤100 CFU/g; No detection of mold, yeast and pathogenic bacteria
Storage Environment Requirements: Sealed container, stored at -20℃, protected from light, avoid moisture and repeated freezing-thawing cycles
Transportation Condition: Low temperature insulated transportation; short-term transit under 2–8℃ is acceptable
Shelf Life: 24 months under recommended sealed storage condition; once the package is opened, it is recommended to finish usage within 1 month
Production Technology & Product Core Characteristics
The manufacturing process of Tirzepatide raw powder adopts advanced solid-phase peptide synthesis technology. During the synthesis process, protective groups are accurately connected to each amino acid monomer step by step, followed by coupling reaction, cleavage reaction and crude peptide collection. The crude peptide enters the purification workshop after preliminary filtration. Multi-cycle reversed-phase high performance liquid chromatography is adopted for separation and purification to remove truncated peptide fragments, incomplete coupling by-products and other impurity substances generated in the synthesis reaction. After purification, the sample is desalted to remove ion impurities in the mobile phase, and then transferred to vacuum freeze-drying equipment. Low-temperature vacuum drying avoids molecular denaturation caused by high-temperature heating, effectively maintaining the natural stability of the peptide spatial structure. After freeze-drying, the finished powder is screened and divided in a dust-free constant-temperature workshop, and then sealed and packaged under inert gas protection to slow down oxidation degradation during storage.
Core advantages of our Tirzepatide research raw material:
First of all, high purity and low impurity profile. The main component purity reaches more than 98%, the content of related peptide impurities is strictly controlled, which can effectively reduce the interference of impurity components on experimental data, improve the repeatability of biochemical experiments and reduce the error fluctuation of research test results. For high-precision mechanism research projects, stable low-impurity raw materials are the basic guarantee to obtain credible experimental data.
Secondly, excellent batch-to-batch consistency. Every batch of raw materials goes through the same standardized production route, unified testing standards and complete sampling inspection. The difference of purity, impurity composition and physical properties between different batches is controlled within a tiny range. For long-cycle continuous research projects that require repeated raw material procurement, stable batch quality can avoid variable factors brought by raw material differences.
Thirdly, stable chemical structure and long storage cycle. The finished powder adopts vacuum freeze-drying molding technology. Under the recommended storage condition, the peptide molecule can maintain stable chemical structure without obvious degradation within the validity period. Meanwhile, we provide professional suggestions on sample splitting, sub-packaging and preservation after opening the package to guide customers to extend the effective service life of raw materials.
Fourthly, flexible packaging specification selection. We support diversified packaging specifications from small laboratory trial packages to large batch industrial research packages. All packaging containers adopt low adsorption brown glass bottles or food-grade aluminum foil vacuum packaging to prevent peptide adsorption on the inner wall of the container and prevent light-induced molecular degradation.
Fifthly, complete supporting test documents. Each batch of products can be accompanied by a formal Certificate of Analysis (COA), including HPLC purity spectrum, mass spectrometry identification report, moisture test record, heavy metal test data and other testing content. Researchers can archive these test documents for project filing, academic paper supplementary materials and laboratory internal audit work.
Quality Control Standard & Testing Items
All quality inspection operations follow universal standards for research-grade synthetic peptide raw materials. A complete independent quality control laboratory is equipped with supporting testing instruments including high performance liquid chromatography, electrospray mass spectrometer, moisture analyzer, atomic absorption spectrophotometer, microbial incubator and pH testing equipment. All testing instruments implement regular calibration management to ensure the accuracy of test data.
The complete inspection items for each batch of Tirzepatide raw powder include:
Character inspection: Visual observation of powder color, shape and uniformity, to confirm whether there is agglomeration, discoloration and abnormal foreign matter.
HPLC purity testing: Quantitative analysis of main component content and all related peptide impurities, confirm single impurity and total impurity level meet the agreed standard.
Mass spectrometry identification: Verify the molecular weight of the target product, match with the theoretical molecular weight of Tirzepatide to confirm correct molecular structure.
Moisture detection: Karl Fischer titration method to test residual moisture inside powder, excessive moisture will accelerate peptide hydrolysis and degradation.
Residual solvent test: Detect the residual amount of organic solvent used in synthesis and purification links to control solvent interference.
Heavy metal detection: Atomic absorption method to test heavy metal pollutant indicators, meet the safety requirements of laboratory biochemical reagents.
Microbial limit test: Detect the number of aerobic bacteria, fungi and pathogenic microorganisms to avoid microbial contamination affecting experimental research.
Solubility test: Conduct dissolution test under standard aqueous phase environment to verify solubility performance for experimental preparation reference.
After all testing items are qualified, the quality control department issues the official batch COA document. If any testing index fails to reach the standard, the batch will be marked as unqualified and will not enter the packaging and delivery process. The whole testing process retains original test spectrum and test records, which can be provided for customer verification upon formal application.
Application Scope & Research Direction
Tirzepatide belongs to dual receptor agonist peptide material, which can activate GLP-1 receptor and GIP receptor simultaneously. This unique molecular mechanism makes it widely applied in multiple branches of biochemical and preclinical research. All listed application directions are limited to laboratory-based scientific research only.
Metabolism related signal pathway research
Researchers utilize this peptide sample to explore the regulation mechanism of glucose metabolism signal pathway, analyze the signal transmission process after receptor activation, compare the signal difference between single receptor agonist and dual receptor agonist, and carry out fundamental research on energy balance regulation mechanism inside cells.
Endocrine biochemistry research
Carry out in vitro cell level experiments, study the influence of peptide molecules on endocrine cell activity, analyze the secretion rule of related metabolic regulatory factors, and provide raw material support for endocrine biochemistry basic research projects.
Cell model experimental research
It can be applied to cell incubation intervention experiments of different cell models. Researchers can set multiple concentration gradients to observe the biological response characteristics of target cells after peptide treatment, and record changes in cell physiological indicators for subsequent data sorting and analysis.
Peptide structure-activity relationship research
Modify partial amino acid sequence on the basis of Tirzepatide skeleton structure, synthesize analogues, and compare the biological activity difference between prototype peptide and modified analogues. This kind of research helps to explore the structure-activity relationship rule of long-chain polypeptide and guide the design of new peptide molecules.
Biochemical analytical method development
Used as reference standard sample for peptide analytical method development. Laboratories can take Tirzepatide as the research object to establish and optimize HPLC detection method, peptide quantitative analysis method, protein binding analysis method and other biochemical detection schemes.
Preclinical mechanism exploratory research
Support non-clinical basic research projects, used for mechanism exploration at tissue and organ level, analyze the comprehensive influence of dual receptor activation on physiological metabolism indexes, accumulate basic experimental data for subsequent peptide research work.
Peptide formulation exploratory research
Researchers can carry out formulation feasibility research, explore different dissolution medium, protective agent matching, stabilization formula, study the stability change rule of peptide solution under different temperature and pH environment, to develop suitable preservation scheme for peptide solution samples.
⚠️ Important usage reminder: This raw powder is research chemical material only. It cannot be used for any cosmetic processing, clinical treatment, human oral application or other commercial application outside laboratory scientific research. All research activities must be carried out in standardized biochemical laboratories equipped with complete safety protection equipment. Operators need to master professional biochemical experiment operation specifications and wear corresponding protective gloves, goggles and protective clothing to avoid direct skin contact or inhalation of powder dust.
Storage, Packaging & Transportation Guidelines
Packaging Options
We provide multiple packaging specifications for selection according to customer research demand:
Small trial package: 10mg, 50mg, 100mg, vacuum sealed aluminum foil packaging or low adsorption brown glass bottle packaging, suitable for laboratory preliminary exploratory experiments.
Medium batch package: 500mg, 1g, 5g, inert gas filled sealed packaging, suitable for medium-scale repeated experimental projects.
Large research batch package: 10g, 50g, 100g and above, customized sealed packaging, oriented to long-cycle continuous research laboratories and biotech R&D institutions.
All outer packaging adopts thick foam box combined with sealed carton. For low-temperature transportation orders, ice packs or dry ice are added inside the packaging box to maintain low-temperature environment during transit. Each package is attached with product label, marking product name, batch number, production date, net weight, storage requirement and validity period.
Storage Guidance
Unopened original package: Keep sealed, store at -20℃, avoid light and humid environment. Do not place the raw material in refrigeration room with frequent temperature fluctuation. Under proper storage, the shelf life reaches 24 months.
After opening the original package: It is recommended to divide the powder into multiple small centrifuge tubes for sub-packaging under dry low-temperature environment. Each sub-package is sealed separately to reduce repeated freezing and thawing frequency. Sealed sub-samples should be stored at -20℃ and used within 30 days.
Avoid repeated melting and freezing: Repeated freezing-thawing cycles will destroy the peptide spatial structure and accelerate molecular degradation, which will lead to the decline of sample activity and increase impurity content.
Isolation storage: Keep away from oxidant, strong acid, strong alkali and volatile organic chemical reagents to prevent chemical cross-contamination.
Dry environment: High humidity environment will cause powder agglomeration and accelerate hydrolysis reaction. Do not leave the raw material bottle open in air for a long time.
Transportation Instruction
Two transportation modes are available for selection: normal cold chain transportation and dry ice low-temperature transportation. For short-distance transportation with transit time less than 5 days, cold chain package with ice packs can meet the demand. For long-distance international transportation with transit time over 7 days, dry ice low-temperature packaging is recommended to maintain stable low temperature. All transportation links avoid direct sunlight exposure. After receiving the goods, customers need to inspect the package integrity immediately. Once the package is damaged, powder leakage or abnormal temperature rise is found, contact our customer service team in time for follow-up processing. After receiving the product, transfer it to the designated low-temperature storage environment as soon as possible.
Safety Operation Information & Risk Tips
Tirzepatide synthetic peptide raw powder belongs to fine biochemical research reagent. Standard laboratory safety operation rules should be followed during all experimental operation processes.
Inhalation risk reminder: Avoid generating powder dust during weighing and splitting operation. Dust inhalation may cause irritation to respiratory tract. Operation is required in fume hood with good ventilation.
Skin contact risk: Prevent direct contact between raw powder and skin. Once accidental contact occurs, rinse the contact position with plenty of clean water immediately.
Eye contact risk: If powder splashes into eyes, continuously wash eyes with sterile water for more than 15 minutes and seek professional medical support if persistent discomfort occurs.
Do not ingest: Strictly prohibit accidental ingestion of raw powder. All experimental operations cannot be carried out in food processing area or drinking area.
Waste disposal: Residual powder, waste solution and experimental waste containing Tirzepatide cannot be discarded arbitrarily. Dispose experimental waste according to local biochemical waste management regulations, adopt centralized harmless treatment mode.
Separate storage: Store separately from daily food, beverage and medical supplies to prevent cross contamination.
Order & Document Support Service
Before formal order confirmation, we can provide product introduction document, standard specification sheet and sample COA template for customer reference. After the order is produced and delivered, each batch of goods is matched with official COA certificate, including complete test spectrum data. If customers need to submit materials for laboratory project filing, we can provide corresponding supporting documents within the scope allowed by product specifications.
For customers with long-term stable research demand, we can provide long-term supply quotation and stable batch guarantee. For special customized purity demand or special packaging requirements, you can communicate with our sales team in advance to confirm whether customized production can be arranged.
All products are delivered based on the specification confirmed by both parties. Before shipment, our warehouse team will recheck the product appearance, packaging tightness and labeling information to ensure no wrong batch and wrong specification delivery. International order customers need to confirm the local biochemical reagent import policy in advance to ensure smooth customs clearance of goods. We can provide corresponding commodity information required for customs declaration.
Disclaimer
Tirzepatide raw powder is sold only for laboratory scientific research, academic experimental research and preclinical mechanism exploration. The seller does not authorize any other application scenarios. Any behavior that uses this product beyond the scope of laboratory research shall be the sole responsibility of the purchaser. The purchaser must abide by the chemical reagent management laws, environmental protection regulations and laboratory safety standards of the country and region where the research activity is located. All operators participating in the experiment should receive professional biochemical experiment safety training. The seller will not bear any legal liability and compensation responsibility caused by improper use, illegal application and non-compliant operation of the product.
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