Pancragen/99% purity/20mg PA20/ Pancreatic regulation

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• Amino Acid Sequence: Lys-Glu-Asp-Ala (Lysine-Glutamic acid-Aspartic acid-Alanine), abbreviated as the single-letter sequence KEDA.

• Substance Classification: It belongs to small-molecule linear polypeptides (synthetic tetrapeptides) and exhibits excellent hydrophilicity.
• Physicochemical Parameters: Its molecular formula is C₁₈H₃₁N₅O₉, with a molecular weight of approximately 461.47 Da.
• Physicochemical Characteristics: It typically appears as a white powder and is soluble in water (H₂O) and DMSO.

• Gene Activation and Anti-aging: Livagen has a direct impact on DNA and gene expression patterns. Studies indicate that it induces chromatin decondensation (unpacking), thereby activating genes in elderly lymphocytes that have been silenced due to aging (including ribosomal genes responsible for protein production and enhancing cellular activity). This revitalizes cells from the inside out and combats aging.
• Promoting Protein Synthesis: Livagen can significantly increase the level of protein synthesis in hepatocytes of animals of various ages, with the most pronounced effects observed in elderly animal cells.
• Regulating the Endogenous  System: Livagen can inhibit enkephalin-degrading enzymes in human serum, and its inhibitory efficiency is superior to certain known peptidase inhibitors.
• Cellular Structure Regulation: As an inducing active peptide, Livagen can increase the number of nucleolar organizer regions (NORs) and nucleoli within each cell, making it useful for research on nucleolus-related cellular processes.

      Pancragen (pancreatic regulatory peptide) is a synthetically produced tetrapeptide bioregulator that primarily targets pancreatic tissue, aiming to support the structural and functional integrity of the pancreas. Below is a detailed introduction to it:

• Amino Acid Sequence: Lys-Glu-Asp-Trp (Lysine-Glutamic acid-Aspartic acid-Tryptophan), abbreviated as the single-letter sequence KEDW.

• Substance Classification: It belongs to small-molecule linear tetrapeptide bioregulators with no additional modifications.
• Physicochemical Parameters: Its molecular formula is C₂₆H₃₆N₆O₉, with a molecular weight of approximately 576.25 Da. The theoretical isoelectric point (pI) is approximately 3.9, making it acidic overall.
• Physicochemical Characteristics: It typically appears as a white to off-white lyophilized powder or solid powder. It is highly soluble in water and PBS buffer, and can also be dissolved in DMSO.

• Regulation of Pancreatic Cell Differentiation: It specifically targets pancreatic cells and upregulates key pancreatic transcription factors (such as PDX1, NGN3, PAX6, FOXA2, and NKX2-2) through site-specific peptide-DNA binding. This promotes the differentiation and maturation of pancreatic acinar cells and islet cells, thereby restoring cellular function.
• Epigenetic Regulation: It reduces the methylation levels in the promoter regions of key genes, activating silenced genes in aging or dysfunctional pancreatic cells and reversing the cellular aging phenotype.
• Endocrine Function Restoration: It regulates the secretion of insulin and C-peptide, improves glucose tolerance, reduces insulin resistance, and restores the pancreas's homeostatic regulatory capacity over blood sugar levels.
• Anti-apoptosis and Cellular Protection: It upregulates the expression of anti-apoptotic proteins (such as Mcl-1) while downregulating the expression of caspase-3 and p53. This inhibits pancreatic cell apoptosis and enhances cell survival rates and functional stability.
• Exocrine Function and Vascular Support: It improves the activity of pancreatic exocrine enzymes to support digestive health. Simultaneously, it enhances microvascular function in pancreatic tissue, offering potential protective effects against capillary fragility and ischemic stress.

      * We will ship your order within 24–48 hours after payment is received.

     * We have dedicated shipping routes, allowing us to select the fastest and safest carrier for your specific destination—including FedEx, UPS, China Post, and other international express services. The estimated delivery time is approximately 7–15 business days.

     * We will also track the logistics throughout the entire process and update the logistics information for buyers in real time.

          Our company is located in Zhejiang Province and is a Chinese enterprise specializing in the production of peptide products.We are not intermediaries or resellers; we are the original manufacturer. This allows us to offer you the most competitive pricing. Our motto is: to manufacture products with care and serve customers with dedication.We are dedicated to serving every visitor with heart. No matter where you come from, you will experience our premium VIP service. We guarantee that every customer receives only the finest products, backed by exceptional after-sales support, as we strive to ensure your complete satisfaction.

1. What's the payment methods?
We could accept pay through Alipay, USDT, BTC and TT.

2.Does the product have a test report?
Each batch of our products undergoes testing before leaving the factory, and a Certificate of Analysis (COA) report is issued.

3.Can customers customize their own labels?

Custom labeling services are available. Please contact us to discuss your specific requirements prior to placing an order.

4.What is the product's shelf life?

When unopened, our products have a shelf life of two years under both room temperature and frozen storage conditions. Therefore, you can rest assured that extended shipping times will not cause the product to expire or degrade.

1.  * Ultra-High Purity Guaranteed
   Every batch is synthesized and purified to >99% purity, delivering the reliability and reproducibility your sensitive experiments demand.
2.  
3. * Precision Dosing & Batch Consistency
   Peptides are accurately weighed and vacuum-sealed under sterile conditions. We enforce rigorous quality control to ensure unwavering consistency from batch to batch.
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5. * Endotoxin-Free & Sterile Assurance
   Produced in a certified cleanroom, our peptides are rigorously tested to be free of endotoxins, microbes, and impurities—safeguarding the integrity of your cell-based and in vivo studies.