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Home > Biochemical Engineering > Polypeptide > Dihexa for Sale > 99% High Purity Raw Material Pharmaceutical Grade Factory Direct Supply Bulk Multiple Packaging Options
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99% High Purity Raw Material Pharmaceutical Grade Factory Direct Supply Bulk Multiple Packaging Options

161 Inquiries

Unit Price:

$105-107/MT FOB

Get Latest Price
CAS No.:

1401708-83-5

Grade:

Pharmaceutical Grade

Content:

99%

Port:

HongKong

Brand:

KangTai

Packaging:

10mg/vials, 10 vials per kit

Price valid (until):

2026-09-13

Company Type:
Trader
Location:
China
Qualification:
Main Products:

Polypeptide

  • Product Description

  • Seller Information

  • Inquiry History

  • Description


      Product Detail  


        Dihexa, also known as PNB-0408 or N-hexanoic-Tyr-Ile-(6)aminohexanoic amide, is a synthetic oligopeptide and functional analog of angiotensin IV. Structurally composed of eight amino acids, this small peptide possesses unique biochemical properties including oral bioavailability and excellent blood-brain barrier penetration ability. It exhibits high binding affinity for hepatocyte growth factor (HGF) and effectively enhances the activation of the downstream c-Met receptor, regulating related cell growth and neural signaling pathways.

        In neuroscience research, Dihexa is widely studied for its neurogenic and synaptic regulatory potential. Multiple preclinical studies have verified that it can promote synaptogenesis, facilitating the formation and remodeling of new synaptic structures in brain tissues. Relevant animal model experiments indicate that Dihexa displays favorable neuroprotective and neuromodulatory properties.

        As a promising research compound, Dihexa has important research value in exploring the mechanisms of nervous system regulation. It provides effective experimental support for fundamental studies on neurodegenerative lesions, age-related cognitive changes, and pathological mechanisms associated with Alzheimer’s disease.

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    800 × 800
    Items Specifications
    Product  Name Dihexa
    CAS number 1401708-83-5

    Grade Standard

    Top Quality

    Grade Pharmaceutical Grade
    Purity 99%


      Why choose us? 


    1. Ultra-High Purity
    Every batch of peptide products undergoes strict chemical synthesis and advanced purification treatment, with the purity tested above 99% by HPLC testing method. High purity effectively reduces the interference of miscellaneous impurities during laboratory testing and research experiments. It can deliver stable, reliable and repeatable experimental data, meeting strict requirements for academic research and related experimental projects.

    2.Accurate Dosing & Consistency
    All peptides are accurately weighed by professional equipment under standardized sterile operating environments, then vacuum-sealed into vials. We implement strict production specifications throughout the whole manufacturing process. Stringent quality inspection standards are adopted to guarantee stable batch-to-batch consistency. Customers do not need to worry about deviations in content, which brings great convenience for repeated comparative experiments.

    3.Endotoxin-Free & Sterile Processing
    Our peptides are produced and packaged in independent cleanroom environments. The whole production chain effectively avoids endotoxin residues, microbial pollution and other harmful impurities. Products can avoid abnormal reaction results caused by contaminants during cell experiments and in-vivo research. The sterile production standard ensures the safety of samples and supports diversified laboratory research needs.

    4.Complete Test Support

    We can provide corresponding HPLC test reports for each batch of goods. All products have complete production records and inspection data. We keep sufficient regular inventory, support flexible customization of specifications such as different dosage vials to satisfy diversified purchasing demands from global buyers.


      Our Factory  


    Shop 99% High Purity Raw Material Pharmaceutical Grade Factory Direct Supply Bulk Multiple Packaging Options-Detailed Image 7 Shop 99% High Purity Raw Material Pharmaceutical Grade Factory Direct Supply Bulk Multiple Packaging Options-Detailed Image 8 Shop 99% High Purity Raw Material Pharmaceutical Grade Factory Direct Supply Bulk Multiple Packaging Options-Detailed Image 9 Shop 99% High Purity Raw Material Pharmaceutical Grade Factory Direct Supply Bulk Multiple Packaging Options-Detailed Image 10 Shop 99% High Purity Raw Material Pharmaceutical Grade Factory Direct Supply Bulk Multiple Packaging Options-Detailed Image 11


      Product Packing  


        Shop 99% High Purity Raw Material Pharmaceutical Grade Factory Direct Supply Bulk Multiple Packaging Options-Detailed Image 12 We have cooperated with experienced shipping forwarders for many years,

     they arrange the shipment.  No matter by express,  by air or by sea,  we will track the course of the goods all the way,  to make sure goods arrive at you on time and in good condition.


      Disclaimer


    These products are APIs (Active Pharmaceutical Ingredient) and not a finished drug.


    It is intended strictly for research and laboratory use only.


    Buyers are required to fully comply with all applicable laws and regulations regarding the handling and use of this material

    Basic Info
    Product Name:

    Dihexa

    Other Name:

    L-Isoleucinamide,N-(1-oxohexyl)-L-tyrosyl-N-(6-amino-6-oxohexyl)-;N-(1-Oxohexyl)-L-tyrosyl-N-(6-amino-6-oxohexyl)-L-isoleucinamide;Dihexa;N-Hexanoic-Tyr-Ile-(6)aminohexanoic amide

    CAS No.:

    1401708-83-5

    Molecular Formula:

    C27H44N4O5

    InChIKeys:

    InChIKey=XEUVNVNAVKZSPT-JTJYXVOQSA-N

    Molecular Weight:

    504.7

    Exact Mass:

    504.66

    Categories:

    Polypeptide

    Characteristics
    Density:

    1.111±0.06 g/cm3(Predicted)

    Boiling Point:

    866.2±65.0 °C(Predicted)

    Research
    Class:

    Angiotensin IV-derived oligopeptide / HGF-c-Met potentiator

    Status:

    Research compound — Not FDA approved

    Mechanism:

    A synthetic, orally active, blood-brain-barrier-permeable oligopeptide (Hexanoyl-Tyr-Ile-Ahx-NH₂) derived from angiotensin IV. Dihexa binds hepatocyte growth factor (HGF) with high affinity (Kd = 65 pM) and allosterically potentiates HGF activity at its receptor c-Met, promoting dendritic spinogenesis and synaptogenesis. In preclinical models it was reported to be seven orders of magnitude more potent than BDNF at promoting synapse formation. Note: the foundational 2014 paper (McCoy AT, et al. Neurobiol Learn Mem. 2014) was retracted in 2025.

    EC50 (HGF Binding KD):

    65 pM

    Activity note:

    Dihexa is an HGF potentiator, not a direct receptor agonist. It does not activate c-Met alone but markedly augments HGF-induced c-Met activation at low nanomolar HGF concentrations. Functional synaptogenic activity was reported at 10⁻¹°–10⁻⁻ M (original data now subject to retraction).

    Source:

    Original report: McCoy AT, et al. Neurobiol Learn Mem. 2014;115:112-120 (retracted 2025). Benoist CC, et al. J Pharmacol Exp Ther. 2014;351(3):628-637.

    Clinical Development:

    NCT04488419

    References
    PubChem:

    PubChem

    UNII:

    9WYX65A5C2

    Disclaimer:

    Dihexa is NOT FDA-approved or EMA-approved as a medicine. It is a research compound only. The foundational 2014 paper describing its synaptogenic potency was retracted in 2025. Its phosphate prodrug fosgonimeton failed a Phase 2/3 Alzheimer’s trial (LIFT-AD, 2024). This listing is for industrial and laboratory research use only. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.

  • Seller Information
    Business Type:

    Trader

    Main Products:

    Polypeptide

    Location:

    Room 205-E742, Building F, No. 53 Congyun Road, Huangshi Street, Baiyun District, Guangzhou City

    Average lead Time:

    15

    Total Annual Revenue:

    Less than $1 million

    Total Employees:

    5-10

    Year of Establishment:

    2026

  • Inquiry History
    161 Inquiries
    Country Product Purchase Quantity Date Posted
    Canada

    Dihexa 1401708-83-5

    1 G Mar 8, 2026
    Bulgaria

    Customized peptides high purity Dihexa with fast shipping door to door CAS 1401708-83-5

    10 G May 27, 2025
    United States

    Dihexa

    25 G Jan 26, 2025
    Russia

    DIHEXA

    50.00 G Aug 14, 2024
    Canada

    Dihexa

    130  Aug 12, 2026
    Brazil

    dihexa

    90 MG Aug 4, 2026
    United States

    Dihexa raw powder

    10 G Jul 26, 2026
    Singapore

    Dihexa

    10 PCS Jul 15, 2026
    United States

    Dihexa

    1 G Jul 11, 2026
    Sweden

    Dihexa

    10 PCS Jul 8, 2026
    Australia

    Dihexa

    1 MT Jul 2, 2026
    United States

    Dihexa

    10 G Jun 14, 2026
    Germany

    Dihexa

    1 G May 25, 2026
    Thailand

    Dihexa

    1 G May 12, 2026
    United States

    Dihexa

    100 G May 4, 2026
    Italy

    simona migliori

    10 MT Apr 23, 2026
    United States

    Dihexa

    1 G Apr 22, 2026
    Ecuador

    DIHEXA

    10 PCS Apr 19, 2026
    United States

    dihexa

    10 MG Apr 13, 2026
    Canada

    Dihexa

    1 G Apr 13, 2026
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