Cisapride Reagent Grade
81098-60-4
Pharmaceutical Grade
99%
shenzhen
Fying
10g/1kg/ 10kg/ 25kg
2026-09-18
vitamin
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Product Description
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Seller Information
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DescriptionECHEMI Editorial ReferenceCisapride(R 51619) is a nonselective 5-HT4 receptor agonist, it is also a potent hERG potassium channel inhibitor.IC50 Value: 0.14 μM(EC50 for 5-HT4 receptor) [1]; 9.8 μM (Kv4.3) [2]Target: 5-HT4 Receptorin vitro: Cisapride showed higher inhibitory effects on a hERG current, as indicated by its IC50 of 9.4 × 10-9 M [1]. cisapride on cloned Kv4.3 channels stably expressed in Chinese hamster ovary cells were investigated using the whole-cell patch-clamp technique. Cisapride inhibited Kv4.3
4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxybenzamide is a member of benzamides.|The serotonin type 4 (5-HT4) receptor agonists are potent prokinetic agents that act on serotonin receptors in the intestine and promote intestinal peristalsis, increase gastric emptying and decrease esophageal reflux. Two 5-HT4 receptor agonists have been developed and were approved for use in the United States, but both were found to have significant serious adverse effects and have been withdrawn (cisapride) or placed under restricted use (tegaserod). Both cisapride and tegaserod have been associated with a low rate of transient serum enzyme elevations during therapy, but neither has been implicated convincing in cases of clinically apparent liver injury with jaundice.|A substituted benzamide used for its prokinetic properties. It is used in the management of gastroesophageal reflux disease, functional dyspepsia, and other disorders associated with impaired gastrointestinal motility. (Martindale The Extra Pharmacopoeia, 31st ed)Basic Info-
Product Name:
Cisapride
Other Name:Benzamide,4-amino-5-chloro-N-[(3R,4S)-1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxy-,rel-;Benzamide,4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxy-,cis-;rel-4-Amino-5-chloro-N-[(3R,4S)-1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxybenzamide;Cisapride;R 51619;Propulsid;Acenalin;(±)-Cisapride;T 1341;Prepulsid;cis-2-Methoxy-4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]benzamide;Propulsin;Alimix;Risamal;Cipril;Coordinax;Cisad;86718-68-5
CAS No.:81098-60-4
Molecular Formula:C23H29ClFN3O4
InChIKeys:InChIKey=DCSUBABJRXZOMT-HJWBXKIQNA-N
Molecular Weight:465.95
Exact Mass:465.95
EC Number:279-689-7
DSSTox ID:DTXSID3022825
Color/Form:White to slightly biege powder
ATC Code:A - Alimentary tract and metabolism
HScode:2942000000
Categories:
Characteristics-
PSA:
86
XLogP3:4.26810
Appearance:white solid
Density:1.3±0.1 g/cm3
Melting Point:109.8 °C
Boiling Point:605.4°C at 760 mmHg
Flash Point:319.9±31.5 °C
Refractive Index:1.593
Water Solubility:DMSO: ~30 mg/mL
Storage Conditions:Store at RT
Odor:Odorless
Experimental Properties:Crystals from 2-propanol /monohydrate/|109.8 °C /monohydrate/
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Trader
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Main Products:
vitamin
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Location:
Room 2-502, Building 6, Luneng Tehran Garden Building, No.8 Changbin Road, Xiuying district, Haikou City, Hainan Province
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Payment Terms:
TT against copy of documents,TT against B/L draft before shipment
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Average lead Time:
25
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Total Annual Revenue:
$2.5 million-$5 million
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Total Employees:
Less than 5
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Year of Establishment:
2023
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
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