Peptides Powder High Quality Semaglutide 99% White powder2 mg/vial 5 mg/vial 10 mg/vial 15 mg/vial 910463-68-25mg*10vials 10mg*10vials 15mg*10vials 20

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Semeglutide is a novel GLP-1 analogue that is subcutaneously once a week. Compared with liraglutide, semaglutide has a longer fat chain and increased hydrophobicity, but semaglutide is modified with a short chain of PEG, and its hydrophilicity is greatly enhanced. After PEG modification, it can not only tightly bind albumin, mask the hydrolysis site of DPP-4 enzyme, but also reduce renal excretion, prolong the biological half-life, and achieve the effect of long circulation.

Mechanism of Action & Advantages

Triple Receptor Agonist: As a triple agonist targeting GLP-1, GIP, and glucagon receptors, Retatrutide enables multi-pathway synergy to regulate blood glucose, energy expenditure, and appetite for comprehensive metabolic control.

Potent Weight Loss & Glucose Control: Clinical data show its weight reduction and glycemic benefits are significantly superior to single or dual receptor agonists, offering a more robust treatment option for severe obesity and type 2 diabetes.

Broader Metabolic Benefits: Beyond weight and glucose, studies indicate positive effects on cardiovascular metabolic markers like blood pressure and lipids.

Clinical Trials & Safety Profile ​

Phase II & III Clinical Trials: In multiple large-scale, randomized, double-blind, placebo-controlled trials, Retatrutide demonstrated outstanding efficacy:

Achieved mean weight reduction exceeding 20% (over 24% in some subgroups) in patients with obesity.

Significantly reduced HbA1c in type 2 diabetes patients alongside substantial weight loss.

The overall safety profile is consistent with the GLP-1 receptor agonist class, with no new safety risks identified.

Industry Recognition: Due to its breakthrough data, Retatrutide is recognized as a major advancement in obesity and diabetes treatment, with research published in leading medical journals.

1、Drug Characteristics

• Long-acting effect: Semaglutide binds to albumin, prolonging its half-life and enabling once-weekly dosing, which significantly improves patient adherence.
• Glycemic control mechanism:
  1. （1）Stimulates insulin secretion and inhibits glucagon release in a glucose-concentration-dependent manner.
  2. （2）Delays gastric emptying, reducing postprandial blood glucose fluctuations.
• Weight loss effect: Suppresses appetite via the central nervous system, reduces food intake, and increases satiety, aiding in weight management.
• Cardiovascular protection: Reduces the risk of major adverse cardiovascular events (MACE), including cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke.
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2、Application:

• 1. （1）Semaglutide is a long-acting dosage form developed based on the basic structure of liraglutide, which is more effective in the treatment of type 2 diabetes.
  2. （2）Semaglutide can be used for weight management in people with mild obesity.

3、Indications

• Type 2 diabetes: Used to improve glycemic control, particularly in patients who do not respond adequately to metformin or other oral antidiabetic agents.

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