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Home > Pharmaceutical Intermediates > Bulk Drug Intermediates > 5-Aminolevulinic acid hydrochloride for Sale > Professional Factory Supply High Qulity 5-Aminolevulinic Acid HCL(5-ALA) CAS 5451-9-2/5451-09-2
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Professional Factory Supply High Qulity 5-Aminolevulinic Acid HCL(5-ALA) CAS 5451-9-2/5451-09-2

3 Inquiries

Unit Price:

$1/KG EXW

Get Latest Price
CAS No.:

5451-09-2

Content:

99%

Port:

shanghai

Packaging:

1kg/as customer's requirment

Price valid (until):

2026-09-19

Company Type:
Trader
Location:
China
Qualification:
Main Products:

Weight Loss Peptide,Anti Aging Peptide,Nootropic,Pharmaceutical Intermediates,Cosmetic raw material,API

  • Product Description

  • Seller Information

  • Inquiry History

  • Description


      Product Detail  


    Main Function

    5‑Aminolevulinic acid hydrochloride is mainly used as a substrate for 5‑aminolevulinate dehydrogenase for biochemical research.

    Uses

    5‑Aminolevulinic acid hydrochloride is a natural amino acid; it serves as a precursor of tetrapyrroles for the biosynthesis of chlorophyll and heme; it is an antitumor drug (photosensitizer).

    Biological Activity

    5‑Aminolevulinic acid HCl is an intermediate in in‑vivo heme biosynthesis and a prodrug of tetrapyrroles.

    Target

    Human Endogenous Metabolite

    In Vitro Study

    5‑Aminolevulinic acid (5‑ALA)‑Photodynamic therapy (PDT) induces the down‑regulation of nuclear factor‑κB (NF‑κB) and baculoviral IAP repeat‑containing‑3 (BIRC‑3) protein. 5‑Aminolevulinic acid (5‑ALA)‑Photodynamic therapy (PDT) increases the ratio of Bax to Bcl‑2 expression and triggers the mitochondrial release of cytochrome c and apoptosis‑inducing factor (AIF). 5‑Aminolevulinic acid causes metal‑catalyzed oxidation of reactive oxygen species, leading to damage to rat liver mitochondria and DNA damage both in vivo and in vitro. 5‑Aminolevulinic acid induces dose‑dependent nuclear and mitochondrial DNA damage in human SVNF fibroblasts and rat PC12 cells. 5‑Aminolevulinic acid reduces cAMP levels in a dose‑dependent manner (maximum inhibition of 38 % at 1 mM) due to inhibition of basal adenylate cyclase activity. 5‑Aminolevulinic acid also inhibits fluoride‑ and Gpp(NH)p‑stimulated, but not forskolin‑stimulated adenylate cyclase activity. 5‑Aminolevulinic acid also suppresses adenylate cyclase activity in membranes isolated from rat cerebral cortex, striatum and human cerebral cortex. 5‑Aminolevulinic acid (0‑3 mM) inhibits glutamate uptake in astrocytes in a dose‑dependent fashion. 5‑Aminolevulinic acid markedly decreases the Kₘ and Vₘₐₓ of glutamate uptake, indicating non‑competitive inhibition. In astrocytes cultured under these conditions, 5‑Aminolevulinic acid significantly elevates astrocytic lipid peroxidation. 5‑Aminolevulinic acid‑mediated sonodynamic therapy exerts synergistic apoptotic effects on THP‑1 macrophages, which involves excessive intracellular reactive oxygen species production and loss of mitochondrial membrane potential (MMP).


    Shop Professional Factory Supply High Qulity 5-Aminolevulinic Acid HCL(5-ALA) CAS 5451-9-2/5451-09-2-Detailed Image 1





    Product Name 5-Aminolevulinic Acid
    Appearance
    Off White powder
    Odor &Taste Characteristic
    Test Method
    HPLC
    Specification 98% min
    Supplier  natural-field
    CAS# 5451-09-2
    Molecular Formula C5H9NO3.HCl

    Shop Professional Factory Supply High Qulity 5-Aminolevulinic Acid HCL(5-ALA) CAS 5451-9-2/5451-09-2-Detailed Image 2


      Our Company


    Shandong Zikang Biotechnology Co., Ltd. is a high-quality manufacturer of chemical raw materials located in Shandong, China. The company mainly deals in fine chemicals and chemical raw materials, with its products sold far to multiple regions including South America, Europe, Southeast Asia and the Middle East. We can provide customized product services for customers. Focused on the production of pharmaceutical intermediates, the company has obtained multiple system certifications. It owns production teams and testing laboratories within Shandong Province. By partnering with our company, you will gain access to premium products, efficient and reliable logistics distribution, and timely after-sales service.
    We are committed to building long-term cooperative relationships with clients, and our business philosophy lies in win-win cooperation, integrity and transparency. Equipped with professional sales and production teams, the company is capable of meeting clients' personalized customized demands.

    Shop Professional Factory Supply High Qulity 5-Aminolevulinic Acid HCL(5-ALA) CAS 5451-9-2/5451-09-2-Detailed Image 3 Shop Professional Factory Supply High Qulity 5-Aminolevulinic Acid HCL(5-ALA) CAS 5451-9-2/5451-09-2-Detailed Image 4


      Packing&Delivery&Shipping  


    Packing:

    1. Weight <1kg ---- Fluorinated bottle

    2. 25kg ---- Plastic bucket

    3. 180- 200kg ---- Drum

    P.S.: we accept packaging customization.

    Shop Professional Factory Supply High Qulity 5-Aminolevulinic Acid HCL(5-ALA) CAS 5451-9-2/5451-09-2-Detailed Image 5

    Delivery:

    We have large quantity raw powder in stock, normally could ship out within 3 working days.

    For rush delivery, please contact our sales team for particular arrangement.


    Shop Professional Factory Supply High Qulity 5-Aminolevulinic Acid HCL(5-ALA) CAS 5451-9-2/5451-09-2-Detailed Image 6

    Shipping:

    We ship goods via DHL, Fedex, UPS, TNT, China post, NL Post and other couriers, weight from 10g to 1000kg or even bulker.

    Shipping details & shipping documents will be provided and sent to customers as long as it is ready.

    We keep tracking the shippment until clients well received.

    After years export shipping experience, with professional and experienced cooperated forwarders, we ensure that goods can be delivered in multiple ways safetly and efficiently.

    Shop Professional Factory Supply High Qulity 5-Aminolevulinic Acid HCL(5-ALA) CAS 5451-9-2/5451-09-2-Detailed Image 7


      FAQ  


    Q1: When will the product be shipped after payment?

    ---We are committed to the same day shipping.

    Q2. How does your factory control quality?

    All the raw material purchasing and production quality control are strictly following the ISO9001: 2008 management system. Besides, the full-featured detection equipment and GMP quality management system provided the strongest guarantee for a high-quality product.

    Q3: How long will it take to receive the parcel?

    --3 days for the US market; 4-6 days for the others.

    Q4: What can I do if I don't have the ability to clear the custom?

    --We got experience after doing export for many years, so don't worry we can handle that.

    Q5: What about after-sale service?

    ---We promise to reissue free of charge if there is any problem.

    If you want to order online,please contact us.

    Shop Professional Factory Supply High Qulity 5-Aminolevulinic Acid HCL(5-ALA) CAS 5451-9-2/5451-09-2-Detailed Image 8

    ECHEMI Editorial Reference
    5-Aminolevulinic acid HCl is an intermediate in heme biosynthesis in the body and the universal precursor of tetrapyrroles.Target: Others5-Aminolevulinic acid is a non-fluorescent prodrug that leads to intracellular accumulation of fluorescent porphyrins in malignant gliomas-a finding that is under investigation for intraoperative identification and resection of these tumours. Median follow-up was 35.4 months (95% CI 1.0-56.7). Contrast-enhancing tumour was resected completely in 90 (65%
    5-aminolevulinic acid hydrochloride is a hydrochloride that is the monohydrochloride of 5-aminolevulinic acid. It is metabolised to protoporphyrin IX, a photoactive compound which accumulates in the skin. Used in combination with blue light illumination for the treatment of minimally to moderately thick actinic keratosis of the face or scalp. It has a role as an antineoplastic agent, a photosensitizing agent, a dermatologic drug and a prodrug. It contains a 5-ammoniolevulinic acid.|Aminolevulinic Acid Hydrochloride is the hydrochloride salt form of aminolevulinic acid, an aminoketone, used for local photosensitizing therapy. Aminolevulinic acid (ALA) is a metabolic pro-drug that is converted into the photosensitizer protoporphyrin IX (PpIX), which accumulates intracellularly. Upon exposure to light of appropriate wavelength (red, or blue), PpIX catalyzes oxygen to singlet oxygen, an intracellular toxin, which can further react to form superoxide and hydroxyl radicals. This leads to cellular cytotoxic effects.|A compound produced from succinyl-CoA and GLYCINE as an intermediate in heme synthesis. It is used as a PHOTOCHEMOTHERAPY for actinic KERATOSIS.
    white to pale yellow crystals or
    Dry ALA-HCl in a vacuum desiccator over P2O5 overnight, then crystallise it by dissolving it in cold EtOH and adding dry Et2O. Also crystallis

    Basic Info
    Product Name:

    5-Aminolevulinic acid hydrochloride

    Other Name:

    5-AminoL;evuL;inic acid hydrochL;TIMTEC-BB SBB003880;DELTA-AMINOLEVULINIC ACID HYDROCHLORIDE CELL CULTUR;5-AminolevulinicAcidHydrochloride(5-Ala);5-Ala;5-Aminolevulinicacidhydrochloride,99%

    CAS No.:

    5451-09-2

    Molecular Formula:

    C5H10ClNO3

    InChIKeys:

    ZLHFONARZHCSET-UHFFFAOYSA-N

    Molecular Weight:

    167.59

    Exact Mass:

    167.035

    BRN:

    3690651

    EC Number:

    226-679-5

    UNII:

    V35KBM8JGR

    NSC Number:

    758687|18509

    DSSTox ID:

    DTXSID5045914

    NCI Thesaurus Code:

    C1849

    Color/Form:

    White to pale yellow

    ATC Code:

    L01XD04

    HScode:

    29224999

    Characteristics
    PSA:

    80.39000

    XLogP3:

    -0.79

    Appearance:

    White to pale yellow powder

    Density:

    1.2±0.1 g/cm3

    Melting Point:

    ~150 °C (dec.)

    Boiling Point:

    311.5±27.0 °C at 760 mmHg

    Flash Point:

    155-157°C

    Refractive Index:

    1.482

    Water Solubility:

    Soluble in dimethyl sulfoxide, methanol and water.

    Storage Conditions:

    2-8°C

    PH:

    pH (10g/l, 25℃) : 2.5~3.0

    Critical Temperature & Pressure:

    -20°C

    Hazard Identification

    Classification of the substance or mixture

    Skin irritation, Category 2

    Eye irritation, Category 2

    GHS label elements, including precautionary statements

    Pictogram(s)
    Signal word

    Warning

    Hazard statement(s)

    H315 Causes skin irritation

    H319 Causes serious eye irritation

    Precautionary statement(s)
    Prevention

    P264 Wash ... thoroughly after handling.

    P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

    Response

    P302+P352 IF ON SKIN: Wash with plenty of water/...

    P321 Specific treatment (see ... on this label).

    P332+P317 If skin irritation occurs: Get medical help.

    P362+P364 Take off contaminated clothing and wash it before reuse.

    P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

    Storage

    none

    Disposal

    none

    Other hazards which do not result in classification

    no data available

    Handling and Storage

    Precautions for safe handling

    Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

    Conditions for safe storage, including any incompatibilities

    Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

  • Seller Information
    Business Type:

    Trader

    Main Products:

    Weight Loss Peptide,Anti Aging Peptide,Nootropic,Pharmaceutical Intermediates,Cosmetic raw material,API

    Location:

    No. 23 Yanjia street, Daixi Subdistrict, Zouping City, Binzhou City, Shandong Province

    Payment Terms:

    TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

    Total Annual Revenue:

    $5 million-$10 million

    Total Employees:

    11-50

    Year of Establishment:

    2026

    Zikang Biotechnology Co., Ltd. is a premium manufacturer of chemical raw materials located in Shandong, China. The company mainly engages in fine chemicals and chemical raw materials, with products sold far to multiple regions including South America, Europe, Southeast Asia and the Middle East. We can provide customized product services for customers. Focused on the production of pharmaceutical intermediates, the company has obtained multiple system certifications. We have production teams and testing laboratories within Shandong Province. By choosing our company as your partner, you will gain premium products, efficient and reliable logistics distribution, as well as timely after-sales service.

    We are committed to building long-term cooperative relationships with clients, guided by the business philosophy of win-win cooperation, integrity and transparency. Boasting professional sales and production teams, our company is capable of fulfilling clients' distinctive customized demands.

  • Inquiry History
    3 Inquiries
    Country Product Purchase Quantity Date Posted
    United States

    API Raw Material 5 Aminoleuvlinic Acid HCL 99% white powder cas 5451-09-2 EGC 5-Aminolevunlinic Acid

    1 MT Feb 16, 2024
    Taiwan, China

    5-Aminolevulinic Acid Hydrochloride

    1 KG Jan 9, 2024
    Spain

    5-aminolevulinic acid

    100 KG Sep 3, 2024
    Post an enquiry for this product
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