CJC- CD5 contains long-acting peptide powder for scientific research purposes.

           

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C-J-C is a high-purity, long-acting synthetic growth hormone-releasing hormone (GHRH) analog developed exclusively for advanced laboratory scientific research. Featuring a unique Drug Affinity Complex structural modification, this lyophilized peptide reagent effectively solves the core defect of rapid enzymatic degradation that plagues native GHRH and ordinary GHRH analogs. As a tetrasubstituted 29-amino-acid modified peptide, it possesses superior plasma stability and sustained biological activity, making it one of the most authoritative and widely adopted research materials in the fields of endocrinology, growth factor regulation, cell metabolism, and physiological cycle research. The product is supplied as premium white to off-white lyophilized powder, with strict purification standards, stable batch consistency, and ultra-low impurity content, fully meeting the experimental requirements of university laboratories, biomedical research institutions, and academic research teams worldwide.

The core technological advantage of5 With DAC lies in its innovative  molecular modification design, which fundamentally distinguishes it from common short-acting GHRH analogs such as Mod GRF 1-29). The  structure is a maleimidopropionic acid residue attached to the peptide’s terminal lysine, which can rapidly and irreversibly bind to cysteine-34 of serum albumin in biological environments. This covalent binding mechanism wraps the peptide molecule in circulating albumin, forming a stable macromolecular complex that effectively isolates the peptide from degradation by dipeptidyl peptidase IV (DPP-IV) and other proteolytic enzymes. Native human GHRH has an extremely short half-life of only 5 to 7 minutes in plasma, while CJC-1295 With  extends its biological half-life to 6 to 8 days, achieving ultra-long-acting biological regulation effects that short-acting peptides cannot match. This stable and sustained activity provides reliable and continuous experimental data support for long-term physiological mechanism research.

In terms of pharmacological mechanism,  With DAC specifically targets and activates GHRH receptors on the surface of pituitary gland cells, stably promoting the synthesis and pulsatile release of growth hormone (GH). Different from the instantaneous GH spike caused by ordinary peptides, the albumin-binding slow-release system of With DAC maintains a gentle, continuous, and physiological GH release level in experimental subjects. This bionic secretion mode avoids the abnormal endocrine fluctuation caused by excessive instantaneous hormone stimulation and perfectly simulates the natural growth hormone secretion rhythm of healthy organisms. Long-term laboratory studies have verified that sustained GH elevation further upregulates the expression of insulin-like growth factor 1 (IGF-1) in the liver and peripheral tissues, forming a complete GH/IGF-1 axis regulation pathway, which is the core theoretical basis for researching growth development, tissue repair, and metabolic regulation mechanisms.

With  has multi-dimensional biological research values, covering multiple core research directions in life science. First, it is widely used in endocrine regulation and growth mechanism research. By stably activating the GH/IGF-1 axis, researchers can explore the regulatory relationship between growth hormone level, body development, and tissue growth, as well as the physiological changes caused by long-term low-amplitude hormone stimulation. Compared with short-acting peptide reagents, its ultra-long half-life eliminates the need for frequent administration in experiments, greatly simplifies the experimental operation process, reduces experimental errors caused by manual operation differences, and improves the accuracy and repeatability of long-cycle experimental data.

Second,With DAC serves as a core reagent for tissue reconstruction and repair mechanism research. The continuously activated GH/IGF-1 axis can significantly promote the proliferation and differentiation of fibroblasts, osteoblasts, and muscle cells, accelerate the synthesis of collagen and extracellular matrix, and facilitate the repair and remodeling of bone tissue, muscle tissue, and connective tissue. In trauma repair and tissue injury model experiments, it can effectively improve tissue regeneration efficiency, reduce scar hyperplasia caused by incomplete repair, and provide a stable experimental tool for exploring the molecular mechanism of tissue damage repair and aging delay. Its sustained metabolic regulation effect also supports in-depth research on body fat metabolism balance, protein synthesis efficiency, and cell energy metabolism regulation.

In addition to core endocrine and metabolic regulation researchalso has important research significance in immune regulation and anti-aging mechanism exploration. Growth hormone and IGF-1 are closely related to immune cell activity and immune organ development. Stable GH level regulation can improve the proliferation activity of lymphocytes and macrophages, enhance the body’s basic immune defense ability, and provide a new perspective for studying the correlation between endocrine level and immune function. At the same time, long-term stable growth factor stimulation can reduce cell oxidative stress damage, delay cell senescence and apoptosis, and support in-depth research on biological aging mechanisms and anti-aging intervention pathways.

In terms of product quality and physical and chemical properties, adopts high-precision solid-phase peptide synthesis technology and multi-stage HPLC purification process, with the peptide purity strictly controlled above 98%. The finished product is uniform white to off-white lyophilized powder, odorless, with excellent water solubility, no insoluble impurities after dissolution, and clear and transparent solution. The product has ultra-low endotoxin content, no heterologous protein pollution, and stable chemical properties, which can effectively avoid experimental interference caused by impurity factors. The vacuum freeze-drying process completely removes residual moisture, locks the molecular activity to the greatest extent, and avoids activity attenuation during storage. Under the recommended storage condition of -20℃ sealed and dry environment, the product maintains stable biological activity for a long time, which is suitable for long-term batch experimental research and repeated verification.

It is necessary to strictly distinguish With  from Without Mod GRF 1-29) in laboratory applications. The non- version has no albumin-binding function, with a short half-life and rapid metabolic clearance, which is only suitable for short-term instantaneous stimulation experiments. In contrast, -modified version is more suitable for long-cycle physiological regulation, continuous metabolic intervention, and stable growth factor level research, with wider experimental applicability and more stable data performance. This essential difference makesWith  an irreplaceable core reagent in long-term endocrine-related experimental research.

The application scenarios of With DAC cover multiple interdisciplinary fields, including endocrinology mechanism research, growth and development biology research, tissue engineering and trauma repair research, cell metabolism and energy regulation research, immune-endocrine interaction research, and aging biology research. As a long-acting single-component peptide reagent with clear mechanism and stable performance, it avoids the functional uncertainty of composite peptides, enables researchers to carry out precise single-variable experimental control, and greatly improves the scientificity and rigor of experimental results. It has become a popular high-end research peptide in global academic laboratories and biomedical research institutions.

Strict safety and usage specifications must be followed for this product. is only for laboratory scientific research use, prohibited for human injection, oral administration, clinical diagnosis and treatment, as well as food, drug, and cosmetic production and processing. All functional descriptions and experimental data of the product are limited to in vitro cell experiments and animal laboratory studies, not for any human clinical application. In summary, relying on its unique DAC long-acting modification technology, stable GH/IGF-1 axis regulation ability, and ultra-high product purity,  With DAC provides a precise, efficient, and reliable long-term experimental intervention tool for modern life science and biomedical research, with high academic research value and broad laboratory application prospects.