Sodium Ferulate CAs24276-84-4 for Biochemical and Pharmacological Studies

Product Overview

Sodium ferulate (CAS 24276-84-4) is the sodium salt form of ferulic acid, a naturally occurring phenolic compound widely distributed in the plant kingdom. Chemically, it is sodium 3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate with the molecular formula C₁₀H₉NaO₄ and a molecular weight of 216.17 g/mol. It is a white to off-white crystalline powder with good solubility in water and aqueous solutions, making it particularly suitable for biological and pharmacological research applications. The compound is stable under proper storage conditions and is supplied at ≥98% purity as determined by HPLC analysis.

Synthetic Process:

Sodium ferulate is typically prepared through a straightforward neutralization reaction from ferulic acid, which can be obtained from natural sources or chemical synthesis:

Preparation of Ferulic Acid: The process begins with the condensation of vanillin and malonic acid via the Knoevenagel reaction in the presence of a base catalyst. The reaction mixture is heated under reflux, followed by acidification to precipitate ferulic acid. The crude product is recrystallized from ethanol to achieve high purity.

Neutralization and Salt Formation: The purified ferulic acid is dissolved in aqueous ethanol and treated with a stoichiometric amount of sodium hydroxide solution under controlled temperature and pH conditions. The neutralization reaction converts the carboxylic acid group to its sodium salt.

Final Product Isolation: The resulting sodium ferulate solution is concentrated under reduced pressure, and the product is precipitated by the addition of a suitable solvent. The crystals are collected, washed, and dried under vacuum to yield the final product with ≥98% purity. Structural confirmation is performed by NMR, IR, and mass spectrometry.

Mechanism of Action

Sodium ferulate exhibits a broad spectrum of biological activities relevant to research applications:

• Antioxidant Activity: The phenolic hydroxyl group effectively scavenges free radicals including hydroxyl radicals and superoxide anions, protecting cellular components from oxidative damage

• Cardiovascular Protection: Modulates platelet aggregation and improves microcirculation through inhibition of thromboxane synthesis and promotion of prostacyclin production

• Anti-thrombotic Effects: Inhibits platelet aggregation and reduces blood viscosity, contributing to its potential cardiovascular protective effects

• Anti-inflammatory Activity: Suppresses the production of inflammatory mediators and cytokines through modulation of NF-κB and other inflammatory signaling pathways

• Neuroprotective Effects: Protects neurons from oxidative stress-induced damage and may support cognitive function

Research Applications & Market Significance

Sodium ferulate is a valuable research tool in multiple fields:

• Cardiovascular Research: Widely used in studies of platelet function, thrombosis, and vascular protection

• Neuropharmacology: Investigated for neuroprotective properties in models of neurodegenerative diseases

• Inflammation Research: Serves as a tool for studying inflammatory pathways and potential anti-inflammatory agents

• Natural Product Chemistry: Used as a reference standard for quality control of herbal medicines

The increasing interest in natural product-derived compounds for therapeutic research has driven demand for high-purity sodium ferulate in academic and industrial research laboratories.

Quality Specifications

Our sodium ferulate is manufactured under strict quality control conditions:

• Purity: ≥98.0% determined by HPLC area normalization

• Identity confirmed by NMR (¹H and ¹³C), IR, and mass spectrometry

• Water content: ≤1.0% determined by Karl Fischer titration

• Residual solvents: Meet ICH Q3C guidelines

• Heavy metals: ≤10 ppm

• Each batch accompanied by comprehensive Certificate of Analysis (COA)

• Stable for 24 months when stored at 2-8°C in sealed containers protected from light

Packaging & Shipping

We offer flexible packaging options to meet diverse customer needs:

• Research quantities: 20mg, 100mg amber glass vials

• Bulk quantities: 1g, 5g amber glass bottles

• Custom packaging available upon request

• Shipped at ambient temperature for routine orders

• International shipping available with proper documentation

• Cold chain shipping available upon request for temperature-sensitive orders