Sodium ferulate
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Sodium ferulate
structure -
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CAS No:
24276-84-4
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Formula:
C10H10O4.Na
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Chemical Name:
Sodium ferulate
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Synonyms:
2-Propenoic acid,3-(4-hydroxy-3-methoxyphenyl)-,sodium salt (1:1);Cinnamic acid,4-hydroxy-3-methoxy-,monosodium salt;2-Propenoic acid,3-(4-hydroxy-3-methoxyphenyl)-,monosodium salt;Ferulic acid,sodium salt;Sodium ferulate;Sodium 3-methoxy-4-hydroxycinnamate
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CAS No:
Description
Ferulic acid (4-hydroxy-3-methoxycinnamic acid) is a phenolic compound present in several plants with claimed beneficial effects in prevention and treatment of disorders linked to oxidative stress and inflammation.IC50 value:Target: 5-HT ReceptorIn vitro: In the present study we have showed that pre-treatment with Ferulic Acid (FA) reduces NO accumulation in the culture medium of LPS-induced macrophage cells. Moreover, real-time experiments have revealed that FA has an inhibitory effect
Light yellow solid powder; Sweet clovey phenolic aroma
Sodium ferulate is an organic sodium salt resulting from the replacement of the proton from the 3-hydroxy group of ferulic acid by a sodium ion. It has a role as a plant metabolite, an antioxidant, a MALDI matrix material, an anti-inflammatory agent, an apoptosis inhibitor and a cardioprotective agent. It contains a ferulate.
Characteristics
69.6
0.16390
Light yellow solid powder; Sweet clovey phenolic aroma
372.3°C at 760 mmHg
150.5ºC
Soluble in water; insoluble in fats and oils
3.34E-06mmHg at 25°C
Drug Information
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)|Agents that prevent BLOOD CLOTTING. (See all compounds classified as Anticoagulants.)|Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)|Gastrointestinal agents that stimulate the flow of bile into the duodenum (cholagogues) or stimulate the production of bile by the liver (choleretic). (See all compounds classified as Cholagogues and Choleretics.)|Substances that eliminate free radicals. Among other effects, they protect PANCREATIC ISLETS against damage by CYTOKINES and prevent myocardial and pulmonary REPERFUSION INJURY. (See all compounds classified as Free Radical Scavengers.)|Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant and Hackh's Chemical Dictionary, 5th ed, p301, p499) (See all compounds classified as Indicators and Reagents.)
3-(4-hydroxy-3-methoxyphenyl)-2-propenoic acid
Sodium ferulate Use and Manufacturing
For the treatment of coronary heart disease, ischemic encephalopathy, leukocytes and thrombocytopenia
Flavouring Agent -> FLAVOURING_AGENT;|Flavoring Agents
Computed Properties
Molecular Weight:216.17
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:216.03985305
Monoisotopic Mass:216.03985305
Topological Polar Surface Area:69.6
Heavy Atom Count:15
Complexity:230
Defined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
Drug Function and Efficacy
Non-peptide endothelin receptor antagonists can antagonize endothelin-induced vasoconstriction, blood pressure increase, and vascular smooth muscle cell proliferation; increase NO synthesis, relax vascular smooth muscle; inhibit platelet aggregation, anti-coagulation, and improve blood rheology characteristics. They can also inhibit cholesterol synthesis, lower blood lipids, scavenge free radicals, prevent and treat lipid peroxidation damage; affect complement, enhance immune function, and have certain analgesic and antispasmodic effects.
Registered Holders
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Chongqing Pharscin Pharmaceutical Co., Ltd.
Active
China
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Shandong Yijian Pharmaceutical Co., Ltd.
Active
China
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Jilin Province Xidian Pharmaceutical Sci-Tech Development Co., Ltd.
Active
China
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