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99% High Purity Niclosamide CAS:34892-17-6 Pharmaceutical API Anthelmintic Raw material

Name: 99% High Purity Niclosamide CAS:34892-17-6 Pharmaceutical API Anthelmintic Raw material
Brand: HyperChem
SKU: pr2608211289
Price: 120 USD
Availability: InStock

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Unit Price:

$120-150/KG FOB

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CAS No.:

34892-17-6

Grade:

Pharmaceutical Grade

Content:

99.9%

Port:

Hangzhou

Brand:

HyperChem

Packaging:

1kg/bag, 5kg/bag, 25kg/Drum

Price valid (until):

2029-01-31

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Hangzhou Hyper Chemicals Limited

Company Type:

Trader

Location:

China

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Main Products:

Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

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Product Description
Seller Information

Description

Name	Niclosamide
CAS number	34892-17-6
Synonym	Niclosamide salt Niclosamide sodium salt Niclosamide salicylanilide
Related APIs #	Closantel — 57808-65-8 Rafoxanide — 22662-39-1 Oxyclozanide — 2277-92-1 Nitroxynil — 1689-89-0
Description	Niclosamide(CAS: 34892-17-6) — Comprehensive Overview Niclosamide (NPP) is a water-soluble salt form of niclosamide, an established anthelmintic agent. By forming a salt, this compound overcomes the notoriously poor aqueous solubility of its parent drug, thereby facilitating research into systemic exposure and expanding its potential applications in both metabolic and oncological studies. This document provides a detailed introduction to its fundamental profile, mechanism of action, and primary research applications. 1. Fundamental Identification and Physicochemical Properties To accurately identify this compound in scientific and industrial contexts, the following table summarizes its core chemical identifiers and physicochemical characteristics: Property Category Detailed Information NPP CAS Registry Number 34892-17-6 Molecular Formula C₁ ₇H ₁ ₈Cl ₂ N ₄ O ₄ Molecular Weight ~413.3 g/mol Typical Appearance White to yellow crystalline powder Solubility Profile Highly improved water solubility (~30 g/L), significantly enhancing its utility in aqueous-based research formulations compared to the parent compound The formation represents a strategic chemical modification. The parent niclosamide exhibits negligible aqueous solubility (~1.6 mg/L), which severely restricts its oral bioavailability and limits its therapeutic utility primarily to luminal indications. NPP was specifically engineered to bypass this biopharmaceutical barrier while retaining the core pharmacological activity of the salicylanilide chemotype . 2. Mechanism of Action The primary mechanism of action revolves around its ability to act as a potent mitochondrial uncoupler, disrupting the fundamental energy metabolism of targeted cells. * Mitochondrial Uncoupling and ATP Inhibition: NPP interferes with the electron transport chain by dissipating the mitochondrial membrane potential. It preventing the effective synthesis of adenosine triphosphate (ATP). Because ATP serves as the essential energy currency for cellular metabolism, its depletion effectively halts the energy supply required for cell survival and proliferation . * Inhibition of Glucose Uptake: In addition to blocking ATP generation, the compound impedes the uptake of glucose. This dual-action approach ensures that the target cells are starved of both existing energy reserves and new nutritional inputs, leading to cellular distress and eventual death . * Broad-Spectrum Biochemical Interaction: Beyond its effects on mitochondria, research indicates that NPP interacts with multiple intracellular signaling cascades. It can modulate second-messenger dynamics (such as Ca²⁺, IP ₃ , and cAMP), influence cytoskeletal architecture, and affect transcription factors related to cellular stress adaptation and inflammatory responses . 3. Primary Applications and Therapeutic Potential Thanks to its enhanced solubility and retained pharmacological profile, NPP has garnered significant attention across various biomedical research fields: * Anthelmintic and Antiparasitic Research: Historically, niclosamide is widely used to treat tapeworm infections. By inhibiting ATP production, it induces paralysis and subsequent destruction of parasitic organisms. NPP retains this potent activity and is frequently studied for its broader spectrum against cestodes and trematodes . * Metabolic Disease and Type 2 Diabetes Mellitus (T2D): In high-fat diet (HFD) induced murine models, NPP has demonstrated remarkable efficacy in mitigating obesity, hyperglycemia, and hepatic steatosis. Its mitochondrial uncoupling effect is believed to enhance energy expenditure and improve insulin sensitivity, making it a promising candidate for anti-obesity and antidiabetic drug development . Oncology and Cancer Stem Cell Research: NPP retains potent in vitro* activity against various cancer cell lines, including glioblastoma. By dysregulating key survival pathways and inducing mitochondrial stress, it inhibits cancer stemness, cell renewal, and metastasis. It is currently being evaluated in preclinical models for colorectal, breast, and prostate cancers . * Antiviral and Anti-inflammatory Studies: As part of drug repurposing initiatives, niclosamide derivatives have shown potential in modulating viral replication cycles and suppressing inflammatory pathways, paving the way for novel antiviral strategies . 4. Pharmacokinetics and Research Considerations When conducting studies with NPP, researchers must account for its distinct pharmacokinetic behavior: Absorption and Bioavailability: Unlike the parent niclosamide, which suffers from extremely low oral bioavailability (F ≈ 10%), the salt form allows for substantially higher systemic exposure. This makes it highly suitable for in vivo* studies requiring consistent plasma concentrations . * Metabolism: Niclosamide undergoes extensive first-pass metabolism in the liver and intestine, primarily via hydroxylation (CYP1A2) and glucuronidation (UGT1A1). While NPP improves solubility, researchers often investigate co-formulations or delivery vehicles to further optimize its metabolic stability and prolong its half-life in systemic circulation . * Safety and Handling Profile: NPP is generally classified under the GHS hazard category as an irritant. Standard laboratory safety protocols require the use of appropriate personal protective equipment (PPE), such as safety goggles and gloves, to prevent accidental inhalation or skin contact with the powder. It is strictly intended for controlled research environments and not for direct clinical or household application without stringent regulatory oversight . 5. Conclusion Niclosamide stands out as a sophisticated evolution of a classic anthelmintic drug. By resolving the critical solubility limitations of niclosamide through salt formation, it unlocks a vast array of research possibilities spanning parasitology, metabolic disorders, and oncology. Its well-defined mechanism as a mitochondrial uncoupler provides a robust foundation for developing next-generation therapeutics aimed at energy-dependent diseases. As research continues to uncover its multi-targeted pathways, NPP remains a vital tool in the modern pharmaceutical and biochemical research landscape.
Molecular Formula	C ₁₇ H ₁₈ Cl ₂ N ₄ O ₄
Molecular Weight	413.3 g/mol
Appearance	White or almost white powder
Quality Standard	USP/EP
Shipping Condition	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition	Dry, dark and at 0-28℃ for short term (days to weeks) or 0-8 ℃ for long term (months to years).
Shelf Life	>2 years if stored properly
Sample package	Double plastic bags inside, fiber drum outside, any quantity available.
Commercial package	Aluminium Tin, Fiber drum
Origin	China

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FAQ

Q1. What is the Hyper chem payment term?
T/T advance
LC at sight
DP at sight
Trade assurance
Money gram

Q2. What is Hyper chem shipment policy?
Our policy is to strive for the quickest shipment time possible, with ready stock sample shipment typically going out the same day that your order was placed. Your satisfaction is very important to us.
For non-ready stock, please contact the Hyper Chem sales team to negotiate.

Q3. What hyper chem will provide after shipment?
For sample orders:
After shipment is done, an timely email including:

Track details (Fedex /TNT/DHL/EMS Track number)

Package photo

COA, MSDS, etc

Dispatch date & Estimated arriving time

Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided
in scan-copy and original, to help customers complete the customs clearance process.

Q4. What is Hyper Chem shipment term?

By Express
DHL  FedEx  TNT  EMS
Fast:5 days around
High cost, door to door service

By Air
Suitable for more than 50kg
Fast :3-7 days Hight cost, port to port, professional broker needed

By Sea
Suitable for more than 500kg
Slow:7-45 days, Low cost, port to port, professional broker needed
We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. Does hyper chem provide a shipment return policy?
Yes, we have.
Return Policy: At Hyper chem, your satisfaction is guaranteed. If you are dissatisfied for any reason with a product, please send back the unused portion along with your packing slip and a brief note on why you were dissatisfied within 45 days of purchase for a full refund to:

Q6. What is hyper chem After-sales service
•Documents support: COA ,MSDS, MOA ,MS Report,HNMR Report,SDS,DMF
• Customer Support: Shipment clearance support, quality issue support
• Automated Customer Service: Our worldwide customers enjoy immediate 24/7 access to the HYPER CHEM support team from any location, at any time.

Company profile

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

Among them, our key client industrial sectors around the global are:

Pharmaceuticals
Nutrition Ingredients/ Dietary supplements
Cosmetic Ingredients
Food Ingredients
Veterinary API
Agriculture fertilizer
Custom Synthesis lab supply

HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.

Certificates

Basic Info

Product Name:

Benzamide, 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxy-, compd. with piperazine (1:?)

Other Name:

Benzamide,5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxy-,compd. with piperazine (1:?);Benzamide,5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxy-,compd. with piperazine;Piperazine,compd. with 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide;Niclosamide piperazine salt

CAS No.:

34892-17-6

Molecular Formula:

C13H8Cl2N2O4.xC4H10N2

InChIKeys:

InChIKey=IAIUNINVFIUGNZ-UHFFFAOYSA-N

Molecular Weight:

413.26

Exact Mass:

412.070496

EC Number:

252-274-8

UNII:

813L87CE24

Categories:

Antiparasitics

Characteristics

PSA:

119.21000

XLogP3:

4.29250

Appearance:

COA

Boiling Point:

424.5ºC at 760 mmHg

Flash Point:

210.5ºC

See More Benzamide, 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxy-, compd. with piperazine (1:?) Properties 

Hazard Identification

Classification of the substance or mixture

no data available

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	no data available
Signal word	no data available
Hazard statement(s)	no data available
Prevention	no data available
Response	no data available
Storage	no data available
Disposal	no data available

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Benzamide, 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxy-, compd. with piperazine (1:?) Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

Location:
Rm. 803, Tower 4, LOFT49 Creative City Pioneer Zone, No.88 Jiru Rd. Gongshu Dist., Hangzhou, 310015 ZJ, China

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$5 million-$10 million

Total Employees:
11-50

Year of Establishment:
2013

Certifications:
Certification Report by Bureau Veritas

About HyperChem

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to meet the needs of a diverse range of pharmaceutical cosmetics ingredients and nootropic supplements companies worldwide.

Our Competitiveness

One-stop supply

Wide Range Of products including pharmaceutical, Cosmetic Ingredients and nootropic supplements

Among all the pharmaceuticals,

90% of them with GMP certificates,

85% of them with DMF files and

50% of them passed FDA approval,

30% get CEP certificate

20% are new R&D products.

Custom Repackaging Service

We can efficiently repackage your material into sample sizes, custom batch-specific sizes, or semi-bulk package sizes according to your specifications. And ensures the product is packaged in a quality-controlled environment and will maintain its integrity throughout every stage of the process.

Quality Control/Quality Assurance

HyperChem is committed to delivering on its promises of top-quality products with verified quality data.

All materials are vigorously inspected by the factory and/or outsourced analytical laboratories to ensure each and every lot meets or exceeds our reference standards.

Trade assurance service with 100% payment protection, It is best achieved by delivering products and services 100% right the first time, on time, every time.

Professional

Transparent Communication

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Professional Suggestion

Beyond Expectation.

We have exclusive partnerships with research and production facilities across the country and we offer varied pharmaceutical services in the most cost-efficient way. The production facilities are GMP, WHO-GMP, EU GMP and US FDA approved and are backed by strong regulatory support such as Dossier, DMF, Tech Pack and relevant Stability studies for regulatory filings.
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