Angoroside C 98% Purity Natural Product Reference Standard Phenylethanoid Glycoside High-Purity Research Material CAS 115909-22-3 for Phytochemical an

Product Overview

Angoroside C is a naturally occurring phenylethanoid glycoside isolated from various medicinal plants, most notably from species of the genus Angelica, Scrophularia, and Plantago. Chemically, it is a glycosidic compound featuring a phenylethyl alcohol moiety linked to a sugar moiety via an O-glycosidic bond, with additional caffeoyl and rhamnosyl substituents. The compound has the molecular formula C₃₆H₄₈O₁₉ and a molecular weight of approximately 784.8 g/mol.

Angoroside C is recognized as a significant bioactive marker compound in traditional Chinese medicinal herbs, particularly in Angelica sinensis (Danggui) and Scrophularia ningpoensis (Xuanshen). It is widely employed in phytochemical analysis, quality control of botanical extracts, and pharmacological research due to its diverse biological activities.

Natural Sources and Biosynthesis

Angoroside C is biosynthesized through the phenylpropanoid and shikimate pathways, involving the conjugation of a phenylethanol unit with activated sugar donors (UDP-glucose, UDP-rhamnose) and caffeoyl-CoA. The compound has been identified in several plant species, including:

• Angelica sinensis (Danggui) – roots

• Scrophularia ningpoensis (Xuanshen) – roots

• Plantago asiatica (Plantain) – seeds and leaves

• Rehmannia glutinosa (Dihuang) – roots

• Various species of the Orobanchaceae and Lamiaceae families

The caffeoyl ester moiety, which is a characteristic structural feature of phenylethanoid glycosides, contributes significantly to the compound's biological activities.

Biological Activities and Research Applications

Angoroside C exhibits a broad spectrum of biological activities that make it a compound of considerable research interest:

• Anti-inflammatory Activity: Potently inhibits the production of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6) and mediators (COX-2, iNOS, NO) through modulation of NF-κB and MAPK signaling pathways

• Antioxidant Effects: Demonstrates strong free radical scavenging activity (DPPH, ABTS, hydroxyl radical) and protects cells against oxidative stress-induced damage

• Neuroprotective Properties: Shows protective effects against neuronal cell death and may have potential in the treatment of neurodegenerative disorders

• Hepatoprotective Activity: Protects liver cells against chemically induced damage through antioxidant and anti-inflammatory mechanisms

• Immunomodulatory Effects: Modulates immune responses, potentially beneficial for autoimmune and inflammatory conditions

• Antimicrobial Activity: Exhibits activity against various bacterial and fungal strains

• Antitumor Potential: Preliminary studies suggest inhibitory effects on cancer cell proliferation and metastasis

Quality Specifications

Our Angoroside C is manufactured under rigorous quality control standards:

• Purity: ≥98.0% determined by HPLC area normalization

• Identity confirmed by NMR (¹H, ¹³C, 2D-COSY, HSQC, HMBC) and high-resolution mass spectrometry

• Water content: ≤1.0% (Karl Fischer)

• Residual solvents: Meet ICH Q3C guidelines

• Each batch supplied with comprehensive Certificate of Analysis (COA)

• Stable for 24 months when stored at -20°C in sealed, light-protected containers

Packaging & Shipping

We offer flexible packaging options for research requirements:

• Research quantities: 20mg, 50mg, 100mg amber glass vials

• Custom packaging available upon request

• Shipped at ambient temperature for routine orders

• International shipping with full documentation available

Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.

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We currently support customized services for most product categories, with supply quantities ranging from milligram (mg), gram (g) to kilogram (kg) levels, as well as wholesale. Product purity covers the full spectrum from 90% to 99.9%, providing customers with one-stop convenient services.

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