Punicalagin 98% Purity Natural Product Reference Standard Ellagitannin High-Purity Research Material CAS 65995-63-3 for Phytochemical and Antioxidant

Product Overview

Punicalagin is a naturally occurring ellagitannin, a class of hydrolyzable tannins found predominantly in the pomegranate (Punica granatum) and other members of the Lythraceae family. It is one of the most abundant and bioactive polyphenolic compounds in pomegranate peel, juice, and rind extracts. Chemically, punicalagin is a large molecular weight ellagitannin with the molecular formula C₄₈H₂₈O₃₀ and a molecular weight of approximately 1084.4 g/mol. It is composed of gallagic acid and ellagic acid units esterified to a glucose core, with a characteristic α,β-unsaturated carbonyl system.

Punicalagin is recognized as a key bioactive marker compound for quality control and standardization of pomegranate-derived products. It is extensively used in phytochemical research, nutraceutical development, and pharmacological studies due to its potent biological activities, particularly its high antioxidant capacity.

Natural Sources and Biosynthesis

Punicalagin is biosynthesized through the shikimic acid and gallic acid pathways, with the condensation of galloyl units and oxidative coupling to form the ellagitannin structure. The compound is predominantly found in:

• Punica granatum (Pomegranate) – peel, rind, juice

• Terminalia chebula (Chebulic myrobalan)

• Terminalia catappa (Indian almond)

• Phyllanthus emblica (Indian gooseberry/Amla)

• Various species of the Combretaceae and Lythraceae families

Pomegranate peel is considered the richest natural source of punicalagin, with content levels ranging from 10-30% of dry weight, depending on cultivar and extraction method.

Biological Activities and Research Applications

Punicalagin exhibits an exceptionally broad spectrum of biological activities due to its potent antioxidant properties:

• Antioxidant Activity: Exhibits one of the highest free radical scavenging capacities among natural polyphenols (superior to vitamin C, vitamin E, and many other antioxidants)

• Anti-inflammatory Effects: Inhibits pro-inflammatory mediators (COX-2, iNOS, TNF-α, IL-6, IL-1β) through modulation of NF-κB and MAPK pathways

• Cardiovascular Protection: Reduces oxidative stress, improves endothelial function, lowers blood pressure, and exhibits anti-atherosclerotic properties

• Antimicrobial Activity: Demonstrates broad-spectrum antimicrobial effects against Gram-positive and Gram-negative bacteria, including pathogenic strains

• Anticancer Potential: Inhibits cancer cell proliferation, induces apoptosis, and suppresses tumor growth and metastasis in various cancer models

• Neuroprotective Activity: Protects neurons against oxidative damage and may have benefits in neurodegenerative diseases

• Gastrointestinal Health: Modulates gut microbiota composition and may help prevent gastrointestinal disorders

• Skin Protection: Exhibits UV-protective and anti-aging effects, making it valuable in cosmetic and dermatological applications

This product is intended exclusively for research purposes and is not for human consumption.

Quality Specifications

Our Punicalagin is manufactured under rigorous quality control standards:

• Purity: ≥98.0% determined by HPLC area normalization

• Identity confirmed by NMR (¹H, ¹³C) and high-resolution mass spectrometry

• Water content: ≤1.0% (Karl Fischer)

• Residual solvents: Meet ICH Q3C guidelines

• Each batch supplied with comprehensive Certificate of Analysis (COA)

• Stable for 24 months when stored at -20°C in sealed, light-protected containers

Packaging & Shipping

We offer flexible packaging options for research requirements:

• Research quantities: 2mg, 5mg, 10mg, 20mg amber glass vials

• Custom packaging available upon request

• Shipped at ambient temperature for routine orders

• International shipping with full documentation available

Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.

Our company is committed to making every effort to provide ideal chemical products to potential customers worldwide, including but not limited to: organic/inorganic reagents, biological reagents, plant extracts, pharmaceutical intermediates, active pharmaceutical ingredients (APIs), reference standards, reference substances, peptides, and more. Meanwhile, we have established long-term and stable cooperative relationships with university laboratories and off-campus research institutions, enabling us to offer tailored product services based on customers' actual needs.

We currently support customized services for most product categories, with supply quantities ranging from milligram (mg), gram (g) to kilogram (kg) levels, as well as wholesale. Product purity covers the full spectrum from 90% to 99.9%, providing customers with one-stop convenient services.

To date, our products have been exported to developed countries such as the United States, Australia, Canada, Mexico, as well as EU member states including France, Germany, and many other countries and regions such as Nigeria, Ghana, Southeast Asia, and other parts of Asia. Our product quality and services have consistently received high praise.

Looking ahead, our company will continue to serve as a bridge connecting China and the world, delivering high-quality products and services to global customers.