Carglinide, a long-acting amylin analogue, 99% pure, research peptide, CAS 1415456-99-3

Cagrilintide (1415456-99-3) | High-Purity GLP-1R/AmyR Dual Agonist Peptide for Obesity & T2DM Research

Product Overview
Cagrilintide, with research codes AM833, NN9838, and ZP8396, is a long-acting acylated amylin analog developed by Novo Nordisk. As a dual agonist peptide targeting both the GLP-1 receptor and the amylin receptor (AmyR), it is currently undergoing Phase III clinical trials (ECHEMI) globally for obesity and type 2 diabetes. Unlike traditional single-target GLP-1 drugs (such as smegglutide) and dual-target GLP-1/GLP-1 drugs (such as telpolide), Cagrilintide achieves more significant weight loss and glycemic control through the synergistic action of the GLP-1 and amylin pathways, making it a breakthrough compound (PMC) in the field of metabolic disease research.




Our Cagrilintide is synthesized using advanced solid-phase peptide synthesis (SPPS) technology, followed by high-resolution purification and lyophilization to ensure maximum stability and biological activity. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) confirming compliance with all specificationsECHEMI

Mechanism of Action: Dual Pathway Synergy

1. GLP-1 Receptor Activation

• Enhances glucose-dependent insulin secretion
• Suppresses glucagon release, reducing hepatic glucose production
• Promotes satiety and reduces food intake
• Slows gastric emptying to improve postprandial glycemic control

2. Amylin Receptor (AmyR) Stimulation

• Potently delays gastric emptying (more pronounced than GLP-1 alone)
• Inhibits appetite through central nervous system pathways
• Reduces body weight by enhancing energy expenditure
• Modulates postprandial glucose fluctuations independently of GLP-1 pathwayECHEMI

⚠️ Critical Note: This product is for research use only and not for human or animal clinical use. It is strictly intended for laboratory research applications only.

Research Applications

1. Obesity Research

• Studying central and peripheral satiety signaling pathways
• Evaluating synergistic weight loss mechanisms with GLP-1 agonists
• Developing novel combination therapies for treatment-resistant obesity

2. Type 2 Diabetes Mellitus (T2DM)

• Investigating glucose-lowering effects beyond insulin secretion
• Exploring postprandial glycemic control mechanisms
• Evaluating beta-cell protection and regeneration potential

3. Metabolic Syndrome

• Researching the role of amylin in lipid metabolism and cardiovascular risk
• Developing polypharmacy approaches for comprehensive metabolic regulationPMC

4. Drug Discovery

• Serving as a reference standard for novel GLP-1/AmyR dual agonists
• Validating amylin receptor as a therapeutic target
• Optimizing peptide modification strategies for enhanced pharmacokinetics

Storage & Stability Guidelines

Powder Form Storage

• Long-term storage: -20°C to -80°C, sealed, protected from light and moisture, under nitrogen atmosphere (3-year shelf life)ECHEMI
• Short-term storage: 2-8°C, sealed, protected from light (1-2 years shelf life)
• Avoid: Repeated freeze-thaw cycles, exposure to extreme temperatures, or prolonged ambient conditions

• Safety Information & Handling

  
  

  Laboratory Safety Precautions

  
  
  • Wear appropriate PPE: gloves, lab coat, safety glasses
  • Use in a well-ventilated fume hood
  • Avoid inhalation, ingestion, or contact with skin and eyes
  • Dispose of waste material in accordance with local regulations for peptide compounds
  
  

  Potential Biological Effects

  
  
  • May cause gastrointestinal reactions (nausea, vomiting, bloating) in animal models—similar to GLP-1 class agents
  • Handle with care as it exhibits potent biological activity at low concentrations
  • Not for human or animal therapeutic use—strictly for research purposes only

Why Choose Our ?

1. Ultra-High Purity (≥99.0%): Ensures minimal interference in research results
2. Structural Integrity: Preserves the critical Cys3-Cys8 disulfide bridge and N-terminal modification
3. Comprehensive Documentation: COA with full analytical data provided for every batch
4. Stability Guaranteed: Rigorous quality control ensures consistent performance
5. Research Expertise: Technical support from experienced peptide scientists
6. Global Shipping: Reliable delivery to research institutions worldwide

Ordering Information

To place an order or request a sample, please contact our sales team:

• Email: 15028854014@163.com
• WhatsApp: +85246277864