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TAK-6531358751-06-0

Name: TAK-6531358751-06-0
Brand: OORENT
SKU: pr2608271072
Price: 33 USD
Availability: InStock

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$33-34/MT FOB

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CAS No.:

1358751-06-0

Grade:

Pharmaceutical Grade

Content:

99.5%

Port:

shanghai

Brand:

OORENT

Packaging:

Vial/Bottle/Bag/Carton

Price valid (until):

2027-11-17

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Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

Qualification:

Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

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Product Description
Seller Information
Inquiry History

Description

Product Detail

TAK-653 Basic information

Product Name:	TAK-653
Synonyms:	Pyrazino[2,1-c][1,2,4]thiadiazine, 9-[4-(cyclohexyloxy)phenyl]-3,4-dihydro-7-methyl-, 2,2-dioxide;TAK-653;9-(4-(Cyclohexyloxy)phenyl)-7-methyl-3,4-dihydropyrazino[2,1-c][1,2,4]thiadiazine 2,2-dioxide;9-[4-(cyclohexyloxy)phenyl]-7-methyl-3H,4H-2λ?-pyrazino[2,1-c][1,2,4]thiadiazine-2,2-dione;NBI-1065845);Osavampator(TAK-653;Osavampator;Unii-9E3toe5riz
CAS:	1358751-06-0
MF:	C19H23N3O3S
MW:	373.47
EINECS:	1592732-453-0
Product Categories:
Mol File:	1358751-06-0.mol

TAK-653 Chemical Properties

Boiling point	540.8±52.0 °C(Predicted)
density	1.38±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO: Slightly soluble: 0.1-1 mg/ml
pka	1.71±0.40(Predicted)
form	Solid
color	White to yellow
InChI	InChI=1S/C19H23N3O3S/c1-14-13-22-11-12-26(23,24)21-19(22)18(20-14)15-7-9-17(10-8-15)25-16-5-3-2-4-6-16/h7-10,13,16H,2-6,11-12H2,1H3
InChIKey	PXJBHEHFVQVDDS-UHFFFAOYSA-N
SMILES	S1(=O)(=O)CCN2C=C(C)N=C(C3=CC=C(OC4CCCCC4)C=C3)C2=N1

Safety Information

MSDS Information

TAK-653 Usage And Synthesis

Uses

Osavampator (TAK-653) is a AMPA receptor positive allosteric modulator. Osavampator selectively binds to AMPA-R in a glutamate-dependent manner and induces Ca2+ influx in hGluA1i CHO cells (EC50 = 3.3 μM). Osavampator improves learning and memory in many models. Osavampator is can be used for the research of depressive disorders[1][2].

Biological Functions

TAK-653 is a selective positive allosteric modulator (PAM) of AMPA receptors exhibiting minimal agonistic activity, elicits an antidepressant-like response while maintaining a favorable safety profile in rat models.

in vivo

Osavampator (0.03-0.3 mg/kg, p.o., single dose) enhances visual learning and memory in normal rats^[2].
Osavampator (0.3 mg/kg, p.o., single dose) enhances sustained attention in the poor performing rats^[2].
Osavampator (0.06 mg/kg, p.o., single dose) improves working memory in monkeys^[2].
Osavampator (1 mg/kg, p.o., single dose) produces antidepressant-like effects in the rat RSBM (reduction of submissive behavior model)^[1].

Animal Model:	Normal rats^[2]
Dosage:	0.03 mg/kg, 0.1 mg/kg, 0.3 mg/kg
Administration:	Oral gavage (p.o.)
Result:	Improved the novelty discrimination index (NDI).

Animal Model:	Poor performing rats^[2]
Dosage:	0.3 mg/kg
Administration:	Oral gavage (p.o.)
Result:	Increased correct responses and decreased omissions in the poor performing rats.

Animal Model:	Fasted monkey^[2]
Dosage:	0.06 mg/kg
Administration:	Oral gavage (p.o.)
Result:	Significantly increased delayed match-to-sample (DMTS) accuracy at a 16-s delay interval. Maintained the beneficial effect 24 h after administration.

Animal Model:	submissive behavior model ^[1]
Dosage:	0.1 mg/kg, 1 mg/kg
Administration:	Oral gavage (p.o.)
Result:	Led to a significant reduction in dominance levels compared with vehicle treatment starting from the seventh day of treatment and maintained throughout the study period. Had a significant effect in reducing dominance levels at 0.1 and 1 mg/kg.

IC 50

5-LO

References

[1] Hara H, et al. TAK-653, an AMPA receptor potentiator with minimal agonistic activity, produces an antidepressant-like effect with a favorable safety profile in rats [J]. Pharmacology Biochemistry and Behavior, 2021, 211: 173289. DOI:10.1016/j.pbb.2021.173289
[2] Suzuki A, et al. Strictly regulated agonist-dependent activation of AMPA-R is the key characteristic of TAK-653 for robust synaptic responses and cognitive improvement [J]. Scientific Reports, 2021, 11(1): 14532. DOI:10.1038/s41598-021-93888-0

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Basic Info

Product Name:

TAK-653

Other Name:

Pyrazino[2,1-c][1,2,4]thiadiazine, 9-[4-(cyclohexyloxy)phenyl]-3,4-dihydro-7-methyl-, 2,2-dioxide;TAK-653;9-(4-(Cyclohexyloxy)phenyl)-7-methyl-3,4-dihydropyrazino[2,1-c][1,2,4]thiadiazine 2,2-dioxide;9-[4-(cyclohexyloxy)phenyl]-7-methyl-3H,4H-2λ?-pyrazino[2,1-c][1,2,4]thiadiazine-2,2-dione;NBI-1065845);Osavampator(TAK-653;Osavampator;Unii-9E3toe5riz

CAS No.:

1358751-06-0

Molecular Formula:

C19H23N3O3S

InChIKeys:

PXJBHEHFVQVDDS-UHFFFAOYSA-N

Molecular Weight:

373.47

Exact Mass:

373.146

Color/Form:

White to yellow

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

81.93

XLogP3:

3.3305

Density:

1.38±0.1 g/cm3(Predicted)

Boiling Point:

540.8±52.0 °C(Predicted)

PKA:

1.71±0.40(Predicted)

Critical Temperature & Pressure:

Store at -20°C

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

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We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
Integrity is the foundation, quality is life. We would like to work together with you to build a greener and brighter future.

Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

36 Inquiries

Country	Product	Purchase Quantity	Date Posted
United States	Anti Depression Raw Powder CAS 1358751-06-0 Tak653	25 TON	Jul 15, 2024
Bulgaria	TAK-653 Powder CAS 1358751-06-0	100 MT	Mar 4, 2025
United States	TAK-653	100 G	Jan 16, 2025
United States	TAK-653	50 G	May 8, 2024
Greece	Osavampator/TAK‑653	1 KG	Mar 4, 2026
Bulgaria	TAK 653	1 G	May 19, 2026
Philippines	TAK-653	500 G	Aug 26, 2026
Australia	Tak-653	2 G	Aug 29, 2026
United States	TAK-653	2 MG	Aug 29, 2026
Norway	TAK-653	1 G	Jul 22, 2026
Italy	TAK 653	1 G	Jul 2, 2026
United States	Tak-653	10 G	Jun 29, 2026
Australia	TAK-653	2 G	Jun 22, 2026
United States	TAK-653	1	Apr 8, 2026
Greece	TAK-653 Powder (CAS 1358751-06-0)	1 G	Mar 4, 2026
Chile	Tak 653	50000 MG	Nov 4, 2024
Sweden	Tak-653	5 G	Aug 28, 2026
China	TAK 653	1 MG	Aug 28, 2026
Singapore	TAK 653	1 G	Aug 26, 2026
United States	Osavampator	5 G	Aug 5, 2026

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TAK-6531358751-06-0

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