Zorifertinib CAS 1626387-80-1 CNS-Penetrant EGFR Inhibitor for NSCLC and Brain Metastasis Research hfd
TDS
1626387-80-1
Reagent Grade
99%
qingdao
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5g, 25g, 100g, 500g
2026-09-28
Medetomidine,Medetomidine hydrochloride,D-Lysergic Acid Methyl Ester,SR17018,Fluralaner,GS-441524
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Product Description
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Seller Information
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DescriptionECHEMI Editorial ReferenceAZD3759 is a potent, oral active, central nervous system-penetrant, EGFR inhibitor. At Km ATP concentrations, the IC50s are 0.3, 0.2, and 0.2 nM for EGFRwt, EGFRL858R, and EGFRexon 19Del, respectively.
AZD-3759 is under investigation in clinical trial NCT03360929 (Evaluate Safety, Tolerability, Pharmacokinetics and Anti-tumor Activity of AZD3759).|Zorifertinib is an orally available inhibitor of the epidermal growth factor receptor (EGFR), with potential antineoplastic activity. Upon oral administration, zorifertinib binds to and inhibits the activity of EGFR as well as certain mutant forms of EGFR. This prevents EGFR-mediated signaling, and may lead to both induction of cell death and inhibition of tumor growth in EGFR-overexpressing cells. EGFR, a receptor tyrosine kinase mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization.Certificates-
TDS
Basic Info-
Product Name:
AZD3759
CAS No.:1626387-80-1
Molecular Formula:C22H23ClFN5O3
InChIKeys:MXDSJQHFFDGFDK-CYBMUJFWSA-N
Molecular Weight:459.9
Exact Mass:459.147339
UNII:67SX9H68W2
NCI Thesaurus Code:C118289
Categories:
Characteristics-
PSA:
79.8
XLogP3:4.1
Appearance:white to off-white solid
Density:1.4±0.1 g/cm3
Melting Point:192.4 °C(醇、酯), 193.3 °C (水)
Flash Point:299.3±30.1 °C
Refractive Index:1.632
Storage Conditions:3 years -20℃ powder, 6 months -80℃ in solvent
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Trader
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Main Products:
Medetomidine,Medetomidine hydrochloride,D-Lysergic Acid Methyl Ester,SR17018,Fluralaner,GS-441524
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Location:
RONGSHENG BEIYUANDAJIE 9, LICHENG DISTRICT,JINAN, SHANDONG CHINA
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Payment Terms:
TT against copy of documents,TT against B/L draft before shipment,100% TT in advance
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Average lead Time:
7
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Total Annual Revenue:
$1 million-$2.5 million
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Total Employees:
11-50
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Year of Establishment:
2022
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