Product Overview

2-Bromo-4-fluorobenzaldehyde is an organic compound with the molecular formula C₇H₄BrFO and molecular weight of 203.01 g/mol. This white to off-white crystalline solid is a valuable intermediate in pharmaceutical and agrochemical research. The compound features a bromine atom at the 2-position, a fluorine atom at the 4-position, and an aldehyde group on the aromatic ring.

Synthetic Process

• Formylation: 3-Fluorobromobenzene is formylated using the Vilsmeier-Haack reaction or other formylation methods

• Oxidation: Alternatively, 2-bromo-4-fluorobenzyl alcohol is oxidized to the aldehyde

• Purification: The crude product is purified by recrystallization or distillation

• Drying: The purified product is dried under vacuum

Mechanism of Action

• Aldehyde Reactivity: The aldehyde group participates in condensation, reduction, and oxidation reactions

• Cross-Coupling Substrate: The aryl bromide enables Suzuki-Miyaura and other coupling reactions

• Fluorinated Building Block: The fluorine atom provides unique electronic properties and metabolic stability

Research Applications & Market Significance

• Pharmaceutical Research: Building block for drug discovery programs

• Agrochemical Synthesis: Intermediate for herbicides and fungicides

• Organic Synthesis: Versatile intermediate for functionalized aromatic compounds

• Material Science: Used in the preparation of specialty polymers and functional materials

Quality Specifications

• Purity: ≥98.0% determined by GC

• Melting point: 54-57°C

• Loss on drying: ≤0.5%

• Storage: 2-8°C, sealed, protected from light

• Stable for 24 months when properly stored

Packaging & Shipping

• Research quantities: 25g, 100g amber glass bottles

• Bulk quantities: 500g, 1kg amber glass bottles

• Shipped at ambient temperature