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Home > Pharmaceutical Intermediates > Bulk Drug Intermediates > Lotilaner for Sale > Lotilaner CAS 1369852-71-0 First-in-Class GABACl Antagonist for Demodex Blepharitis and Veterinary Parasiticide hf
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Lotilaner CAS 1369852-71-0 First-in-Class GABACl Antagonist for Demodex Blepharitis and Veterinary Parasiticide hf buy - image1
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Lotilaner CAS 1369852-71-0 First-in-Class GABACl Antagonist for Demodex Blepharitis and Veterinary Parasiticide hf

TDS 3 Inquiries

Unit Price:

$100-130/G FOB

Get Latest Price
CAS No.:

1369852-71-0

Grade:

Reagent Grade

Content:

99%

Port:

qingdao

Brand:

//

Packaging:

5g, 25g, 100g, 500g

Price valid (until):

2026-09-28

Company Type:
Trader
Location:
China
Payment Terms:
TT against copy of documents,TT against B/L draft before shipment,100% TT in advance
Average Lead Time:
7 days
Qualification:
Main Products:

Medetomidine,Medetomidine hydrochloride,D-Lysergic Acid Methyl Ester,SR17018,Fluralaner,GS-441524

  • Product Description

  • Seller Information

  • Inquiry History

  • Description

    —— Product Specification ——

    Parameter Specification Details
    Product Name Lotilaner Credelio; XDEMVY; TP-03
    CAS Number 1369852-71-0 1369852-71-0 
    Molecular Formula C₂₀H₁₄Cl₃F₆N₃O₃S 20 carbons, 14 hydrogens, 3 chlorine, 6 fluorine, 3 nitrogens, 3 oxygens, 1 sulfur 
    Molecular Weight 596.76 g/mol — 
    Appearance White solid Visual inspection 
    Purity ≥98.0% Determined by HPLC
    IC₅₀ (Drosophila GABACl) 23.84 nM Potent GABACl inhibition 
    IC₅₀ (Rhipicephalus microplus) 36.79 nM — 
    Solubility DMSO: >100 mg/mL — 
    Storage Powder: -20°C (3 years), 4°C (2 years); In solvent: -80°C (6 months), -20°C (1 month) Sealed containers, protect from moisture and light 
    Packaging 10mg, 25mg, 50mg, 100mg, 500mg, 1g Amber glass vials
    Application Research use only Veterinary pharmacology, parasiticide research


    —— Product Detail ——

    Product Overview

    • Lotilaner (CAS 1369852-71-0), also known by the Chinese name and marketed under the brand names Credelio (veterinary) and XDEMVY (human ophthalmic), is a first-in-class isoxazoline-class ectoparasiticide that acts as a highly selective, non-competitive antagonist of γ-aminobutyric acid (GABA)-gated chloride channels (GABACls) in arthropods . It appears as a white solid with the molecular formula C₂₀H₁₄Cl₃F₆N₃O₃S and a molecular weight of 596.76 g/mol .


    Packaging & Shipping

                  • Research quantities: 5mg, 10mg, 25mg amber glass vials

                  • Bulk quantities: 50mg, 100mg amber glass bottles

                  • Custom packaging available upon request

                  • Not classified as hazardous material for transport under normal conditions

                  • Product for research and analytical use only; not for human therapeutic use

    Shop CAS 18048-64-1 Eltrombopag Intermediate for Pharmaceutical Research  kr-Detailed Image 1

    Company profile ——


     Shop CAS 1231930-42-9 Abemaciclib Intermediate for Pharma researech use KR-Detailed Image 1

    Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.

    Our company is committed to making every effort to provide ideal chemical products to potential customers worldwide, including but not limited to: organic/inorganic reagents, biological reagents, plant extracts, pharmaceutical intermediates, active pharmaceutical ingredients (APIs), reference standards, reference substances, peptides, and more. Meanwhile, we have established long-term and stable cooperative relationships with university laboratories and off-campus research institutions, enabling us to offer tailored product services based on customers' actual needs.

    We currently support customized services for most product categories, with supply quantities ranging from milligram (mg), gram (g) to kilogram (kg) levels, as well as wholesale. Product purity covers the full spectrum from 90% to 99.9%, providing customers with one-stop convenient services.

    To date, our products have been exported to developed countries such as the United States, Australia, Canada, Mexico, as well as EU member states including France, Germany, and many other countries and regions such as Nigeria, Ghana, Southeast Asia, and other parts of Asia. Our product quality and services have consistently received high praise.

    Looking ahead, our company will continue to serve as a bridge connecting China and the world, delivering high-quality products and services to global customers.

     

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    Shop CAS 1231930-42-9 Abemaciclib Intermediate for Pharma researech use KR-Detailed Image 3

    —— Q&A ——

    Q1: How to confirm the product quality before placing orders?
    A: By sending you available samples. Or if you have special requirements for the goods, we can prepare samples according to your requirements for confirmation.

    Q2: Can you supply free samples?
    A: Yes, we can provide a free sample, but the shipping cost will be paid by the customers. You can either pay the shipping cost or arrange a courier to collect the samples.

    Q3: How do you treat quality complaints?
    A: All our products are strictly tested by our QC and confirmed by QA; unqualified material will not be released to customers. If any quality problem is confirmed to be caused by us, we will replace the goods or refund your payment immediately.

    Q4: What is your MOQ? Is there a discount?
    A: For highvalue products, our MOQ starts from 1g and generally starts from 10g. For other lowprice products, our MOQ starts from 100g and 1kg.
    Q: Is there a discount?
    A: Yes, for larger quantities, we always support with better prices.

    Q5: How to start orders or make payments?
    A: You can send us your Purchase Order (if your company has one), or just send a simple confirmation by email or via Trade Manager. We will then send you a Proforma Invoice with our bank details for your confirmation, and you can make payment accordingly. If you have other preferred payment methods, we are open to discussion and negotiation.



    ECHEMI Editorial Reference
    Lotilaner is a representative of the isoxazolines, a new class of insecticides discovered in the 2000s.Isoxazolines (Afoxolaner, Fluralaner, Lotilaner, and Sarolaner) Isoxazolines are insecticidal and arachnicidal substances that can be given orally, or topically as spot-ons, and act systemically in the blood circulation.lotilaner (Credeliot), a novel oral isoxazoline against naturally occurring mange mite infestations in dogs caused by Demodex spp.Lotilaner, like the other isooxazolines is active against fleas, mites, and ticks. After oral administration or topical application, it can kill fleas rapidly.

    Certificates
    • Lotilaner CAS 1369852-71-0 First-in-Class GABACl Antagonist for Demodex Blepharitis and Veterinary Parasiticide hf Certificates 1 TDS

    Basic Info
    Product Name:

    Lotilaner

    Other Name:

    Lotilaner;(S)-5-[5-(3,4,5-trichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-3-methyl-thiophene-2-carboxylic acid [(2,2,2-trifluoro-ethylcarbamoyl)-methyl]-amide;2-Thiophenecarboxamide, 5-[(5S)-4,5-dihydro-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-3-isoxazolyl]-3-methyl-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-;Parasite,Inhibitor,γ-Aminobutyric acid Receptor,Lotilaner,inhibit,Gamma-aminobutyric acid Receptor,GABA Receptor;(S)-3-Methyl-N-(2-oxo-2-((2,2,2-trifluoroethyl)a mino)ethyl)-5-(5-(3,4,5-trichlorophenyl)-5-(trifluo romethyl)-4,5-dihydroisoxazol-3-yl)thiophene-2- carboxamide;Lotilaner (TP-05);Lotilaner, 10 mM in DMSO;Lotilaner Impurity2

    CAS No.:

    1369852-71-0

    Molecular Formula:

    C20H14Cl3F6N3O3S

    InChIKeys:

    HDKWFBCPLKNOCK-SFHVURJKSA-N

    Molecular Weight:

    596.76

    Exact Mass:

    596.76

    Color/Form:

    White to off-white

    Characteristics
    Density:

    1.66±0.1 g/cm3(Predicted)

    PKA:

    12.52±0.46(Predicted)

    Critical Temperature & Pressure:

    Store at -20°C

  • Seller Information
    Business Type:

    Trader

    Main Products:

    Medetomidine,Medetomidine hydrochloride,D-Lysergic Acid Methyl Ester,SR17018,Fluralaner,GS-441524

    Location:

    RONGSHENG BEIYUANDAJIE 9, LICHENG DISTRICT,JINAN, SHANDONG CHINA

    Payment Terms:

    TT against copy of documents,TT against B/L draft before shipment,100% TT in advance

    Average lead Time:

    7 days

    Total Annual Revenue:

    $1 million-$2.5 million

    Total Employees:

    11-50

    Year of Establishment:

    2022

    Jinan Topfull Chemical Co., Ltd. is a global chemical Industrial and focuses on advanced chemical technology. Specialized in Cosmetic materials, water treatment, fine chemicals and so on. We are looking forward to working together with the people of all circles at home and abroad to seek common development!
  • Inquiry History
    3 Inquiries
    Country Product Purchase Quantity Date Posted
    Bangladesh

    Lotilaner

    50 G Nov 18, 2024
    United States

    Lotilaner

    2 G Jun 29, 2026
    United States

    Lotilaner

    1 KG Oct 1, 2024
    Post an enquiry for this product
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