Oclacitinib Maleate CAS 1208319-27-0 Selective JAK1 Inhibitor for Canine Atopic Dermatitis Research hfd
TDS 3 Inquiries
1208319-27-0
Reagent Grade
99%
qingdao
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5g, 25g, 100g, 500g
2026-09-29
Medetomidine,Medetomidine hydrochloride,D-Lysergic Acid Methyl Ester,SR17018,Fluralaner,GS-441524
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Product Description
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Seller Information
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Inquiry History
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DescriptionECHEMI Editorial ReferenceAPOQUEL (oclacitinib maleate) was the first selective Janus kinase (JAK) inhibitor to be developed for dogs. It was recently approved for the control of pruritus associated with allergic dermatitis and control of atopic dermatitis in dogs at least 12 months of age. In recent years, there has been a significant evolution in understanding regarding the pathophysiology of allergic and atopic diseases. The molecular mechanisms involved in stimulating the itch response have been elaborated (Marsella et al., 2012), and it is now understood that cytokines play a key role in initiating the neuronal itch stimulation which triggers pruritic behavior (scratching, rubbing, chewing, etc.) in dogs. This leads to the establishment of a vicious cycle of itch that exacerbates skin lesions and amplifies defects in the skin barrier function in clinically affected dogs. This progress provided the opportunity to develop new treatments (Marsella et al., 2012). Specifically, Janus kinases play a central role in cytokine signaling and are involved in signal transduction of many pro-inflammatory, pro-allergic, and pruritogenic cytokines including IL-2, IL-4, IL-6, IL-13, and IL-31 that are implicated in allergic conditions (Ong & Leung, 2006; Carmi-Levy et al., 2011).Certificates
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TDS
Basic Info-
Product Name:
Oclacitinib Maleate(PF-03394197)
Other Name:Oclacitinib Maleate(PF-03394197);N-methyl-1-((1r,4r)-4-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)cyclohexyl)methanesulfonamide Maleate;Oclacitinib Maleate;PF 03394197-11;Oclacitinib Meleate;Oclacitinib maleate (PF-03394197 maleate);N-methyl-1-[4-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclohexyl]methanesulfonamide;Oclacitinib Maleate [VET]
CAS No.:1208319-27-0
Molecular Formula:C19H27N5O6S
InChIKeys:VQIGDTLRBSNOBV-VQIYXBGXNA-N
Molecular Weight:453.51
EC Number:200-001-8
Color/Form:White to Off-White
Categories:
Characteristics-
Melting Point:
135 - 137°C
Critical Temperature & Pressure:-20°C, Inert atmosphere
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Seller Information
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Business Type:
Trader
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Main Products:
Medetomidine,Medetomidine hydrochloride,D-Lysergic Acid Methyl Ester,SR17018,Fluralaner,GS-441524
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Location:
RONGSHENG BEIYUANDAJIE 9, LICHENG DISTRICT,JINAN, SHANDONG CHINA
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Payment Terms:
TT against copy of documents,TT against B/L draft before shipment,100% TT in advance
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Average lead Time:
7
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Total Annual Revenue:
$1 million-$2.5 million
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Total Employees:
11-50
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Year of Establishment:
2022
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Inquiry History3 Inquiries
Country Product Purchase Quantity Date Posted
United States
Oclacitinib Maleate(PF-03394197)
50 G Oct 14, 2023
Paraguay
OCLOCITINIB MALEATE
1 KG Apr 16, 2026
Paraguay
OCLOCITINIB MALEATE
1 KG Oct 17, 2025 Post an enquiry for this product