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Home > Pharmaceutical Intermediates > Bulk Drug Intermediates > Bortezomib for Sale > Bortezomib CAS 179324-69-7 First-in-Class Proteasome Inhibitor for Multiple Myeloma and Mantle Cell Lymphoma Research High Purity hfd
Bortezomib CAS 179324-69-7 First-in-Class Proteasome Inhibitor for Multiple Myeloma and Mantle Cell Lymphoma Research High Purity hfd buy - large image1
Bortezomib CAS 179324-69-7 First-in-Class Proteasome Inhibitor for Multiple Myeloma and Mantle Cell Lymphoma Research High Purity hfd buy - image1
Bortezomib CAS 179324-69-7 First-in-Class Proteasome Inhibitor for Multiple Myeloma and Mantle Cell Lymphoma Research High Purity hfd buy - image2
Bortezomib CAS 179324-69-7 First-in-Class Proteasome Inhibitor for Multiple Myeloma and Mantle Cell Lymphoma Research High Purity hfd buy - image3
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Bortezomib CAS 179324-69-7 First-in-Class Proteasome Inhibitor for Multiple Myeloma and Mantle Cell Lymphoma Research High Purity hfd buy - image5
Bortezomib CAS 179324-69-7 First-in-Class Proteasome Inhibitor for Multiple Myeloma and Mantle Cell Lymphoma Research High Purity hfd buy - image6

Bortezomib CAS 179324-69-7 First-in-Class Proteasome Inhibitor for Multiple Myeloma and Mantle Cell Lymphoma Research High Purity hfd

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Unit Price:

$100-130/G FOB

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CAS No.:

179324-69-7

Grade:

Reagent Grade

Content:

99%

Port:

qingdao

Brand:

//

Packaging:

5g, 25g, 100g, 500g

Price valid (until):

2026-09-29

Company Type:
Trader
Location:
China
Qualification:
Main Products:

Medetomidine,Medetomidine hydrochloride,D-Lysergic Acid Methyl Ester,SR17018,Fluralaner,GS-441524

  • Product Description

  • Seller Information

  • Inquiry History

  • Description

    —— Product Specification ——

    Parameter Specification Details
    Product Name Bortezomib [(1R)-3-Methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic acid 
    CAS Number 179324-69-7 179324-69-7 
    Molecular Formula C₁₉H₂₅BN₄O₄ — 
    Molecular Weight 384.24 g/mol — 
    Appearance White to off-white powder Visual inspection 
    Purity ≥98.0% Determined by HPLC
    Melting Point 122 – 124°C — 
    Density 1.214 g/cm³ — 
    Solubility Soluble in DMSO, chloroform, ethanol, methanol; slightly soluble in water  —
    pKa 9.66 ± 0.43 (Predicted) — 
    Storage -20°C, inert atmosphere, protect from moisture Hygroscopic and moisture-sensitive 
    Packaging 5mg, 10mg, 25mg, 50mg, 100mg, 500mg, 1g Amber glass vials
    Application Research use only Oncology research, proteasome inhibition studies


    —— Product Detail ——

    Product Overview

    • Bortezomib (CAS 179324-69-7), originally designated as PS-341, is a first-in-class, potent, and reversible inhibitor of the 26S proteasome . It appears as a white to off-white powder with the molecular formula C₁₉H₂₅BN₄O₄ and a molecular weight of 384.24 g/mol .


    Packaging & Shipping

                  • Research quantities: 5mg, 10mg, 25mg amber glass vials

                  • Bulk quantities: 50mg, 100mg amber glass bottles

                  • Custom packaging available upon request

                  • Not classified as hazardous material for transport under normal conditions

                  • Product for research and analytical use only; not for human therapeutic use

    Shop CAS 18048-64-1 Eltrombopag Intermediate for Pharmaceutical Research  kr-Detailed Image 1

    — Company profile ——


     Shop CAS 1231930-42-9 Abemaciclib Intermediate for Pharma researech use KR-Detailed Image 1

    Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.

    Our company is committed to making every effort to provide ideal chemical products to potential customers worldwide, including but not limited to: organic/inorganic reagents, biological reagents, plant extracts, pharmaceutical intermediates, active pharmaceutical ingredients (APIs), reference standards, reference substances, peptides, and more. Meanwhile, we have established long-term and stable cooperative relationships with university laboratories and off-campus research institutions, enabling us to offer tailored product services based on customers' actual needs.

    We currently support customized services for most product categories, with supply quantities ranging from milligram (mg), gram (g) to kilogram (kg) levels, as well as wholesale. Product purity covers the full spectrum from 90% to 99.9%, providing customers with one-stop convenient services.

    To date, our products have been exported to developed countries such as the United States, Australia, Canada, Mexico, as well as EU member states including France, Germany, and many other countries and regions such as Nigeria, Ghana, Southeast Asia, and other parts of Asia. Our product quality and services have consistently received high praise.

    Looking ahead, our company will continue to serve as a bridge connecting China and the world, delivering high-quality products and services to global customers.

     

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    —— Q&A ——

    Q1: How to confirm the product quality before placing orders?
    A: By sending you available samples. Or if you have special requirements for the goods, we can prepare samples according to your requirements for confirmation.

    Q2: Can you supply free samples?
    A: Yes, we can provide a free sample, but the shipping cost will be paid by the customers. You can either pay the shipping cost or arrange a courier to collect the samples.

    Q3: How do you treat quality complaints?
    A: All our products are strictly tested by our QC and confirmed by QA; unqualified material will not be released to customers. If any quality problem is confirmed to be caused by us, we will replace the goods or refund your payment immediately.

    Q4: What is your MOQ? Is there a discount?
    A: For highvalue products, our MOQ starts from 1g and generally starts from 10g. For other lowprice products, our MOQ starts from 100g and 1kg.
    Q: Is there a discount?
    A: Yes, for larger quantities, we always support with better prices.

    Q5: How to start orders or make payments?
    A: You can send us your Purchase Order (if your company has one), or just send a simple confirmation by email or via Trade Manager. We will then send you a Proforma Invoice with our bank details for your confirmation, and you can make payment accordingly. If you have other preferred payment methods, we are open to discussion and negotiation.



    ECHEMI Editorial Reference
    Yellow SolidChEBI: L-Phenylalaninamide substituted at the amide nitrogen by a 1-(dihydroxyboranyl)-3-methylbutyl group and at Nalpha by a pyrazin-2-ylcarbonyl group. It is a dipeptidyl boronic acid tha reversibly inhibits the 26S proteasome.Bortezomib, a modified dipeptidyl boronic acid, is a therapeutic proteasome inhibitors used for the treatment of cancers. It is indicated for the treatment of relapsed multiple myeloma and mantle cell lymphoma. It is capable of inhibiting the mammalian 26S
    Solid
    Bortezomib is l-Phenylalaninamide substituted at the amide nitrogen by a 1-(dihydroxyboranyl)-3-methylbutyl group and at N(alpha) by a pyrazin-2-ylcarbonyl group. It is a dipeptidyl boronic acid that reversibly inhibits the 26S proteasome. It has a role as an antineoplastic agent, a proteasome inhibitor, a protease inhibitor and an antiprotozoal drug. It is an amino acid amide, a member of pyrazines and a L-phenylalanine derivative. It derives from a boronic acid.|Bortezomib is a dipeptide boronic acid derivative and proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. It is a reversible inhibitor of the 26S proteasome, which is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway. Inhibition of 26S proteasome leads to cell cycle arrest and apoptosis of cancer cells. While inhibition of the 26S proteasome is the main mechanism of action, multiple mechanisms may involved in the therapeutic action of bortezomib. In May 2003, bortezomib became the first anticancer proteasome inhibitor that was approved by the FDA. Phase I, II, III, and IV clinical trials are undergoing to investigate the therapeutic efficacy of bortezomib in leukemia, myasthenia gravis, systemic lupus erythematosus, rheumatoid arthritis, and solid tumours.|Bortezomib is a Proteasome Inhibitor. The mechanism of action of bortezomib is as a Proteasome Inhibitor.|Bortezomib is a proteasome inhibitor and antineoplastic agent that is used in treatment of refractory multiple myeloma and certain lymphomas. Bortezomib is associated with a low rate of serum enzyme elevations during treatment and to rare instances of clinically apparent, acute liver injury.|Bortezomib is a dipeptide boronic acid analogue with antineoplastic activity. Bortezomib reversibly inhibits the 26S proteasome, a large protease complex that degrades ubiquinated proteins. By blocking the targeted proteolysis normally performed by the proteasome, bortezomib disrupts various cell signaling pathways, leading to cell cycle arrest, apoptosis, and inhibition of angiogenesis. Specifically, the agent inhibits nuclear factor (NF)-kappaB, a protein that is constitutively activated in some cancers, thereby interfering with NF-kappaB-mediated cell survival, tumor growth, and angiogenesis. In vivo, bortezomib delays tumor growth and enhances the cytotoxic effects of radiation and chemotherapy.|A pyrazine and boronic acid derivative that functions as a reversible PROTEASOME INHIBITOR. It is used as an ANTINEOPLASTIC AGENT in the treatment of MULTIPLE MYELOMA and MANTLE CELL LYMPHOMA.

    Certificates
    • Bortezomib CAS 179324-69-7 First-in-Class Proteasome Inhibitor for Multiple Myeloma and Mantle Cell Lymphoma Research High Purity hfd Certificates 1 TDS

    Basic Info
    Product Name:

    Bortezomib

    Other Name:

    Boronic acid,B-[(1R)-3-methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)amino]propyl]amino]butyl]-;Boronic acid,[3-methyl-1-[[1-oxo-3-phenyl-2-[(pyrazinylcarbonyl)amino]propyl]amino]butyl]-,[S-(R*,S*)]-;Boronic acid,[(1R)-3-methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(pyrazinylcarbonyl)amino]propyl]amino]butyl]-;B-[(1R)-3-Methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic acid;PS 341;PS 341 (pharmaceutical);MG 341;LDP 341;Bortezomib;MLN 341;Velcade;NSC 681239;DPBA;Radiciol;PS 314;Brotezamide;197730-97-5

    CAS No.:

    179324-69-7

    Molecular Formula:

    C19H25BN4O4

    InChIKeys:

    InChIKey=GXJABQQUPOEUTA-RDJZCZTQSA-N

    Molecular Weight:

    384.23700

    Exact Mass:

    384.24

    EC Number:

    605-854-3

    UNII:

    69G8BD63PP

    NSC Number:

    681239

    DSSTox ID:

    DTXSID3040980

    NCI Thesaurus Code:

    C1851

    Color/Form:

    Powder

    ATC Code:

    L01XG01|L01XX32|L - Antineoplastic and immunomodulating agents

    HScode:

    2934999090

    Characteristics
    PSA:

    124.44000

    XLogP3:

    log Kow = 2.0 (est)

    Density:

    1.214

    Melting Point:

    122-124ºC

    Refractive Index:

    1.564

    Water Solubility:

    The solubility of bortezomib, as the monomeric boronic acid, is 3.3 to 3.8 mg/mL in a pH range of 2 to 6.5.

    Storage Conditions:

    Unopened vials may be stored at controlled room temperature 25 deg C (77 deg F); excursions permitted from 15 to 30 deg C (59 to 86 deg F). Retain in original package to protect from light.

    Vapor Pressure:

    5.1X10-20 mm Hg at 25 deg C (est)

    Henrys Law Constant:

    Henry's Law constant = 3.4X10-22 atm-cu m/mol at 25 °C (est)

    Experimental Properties:

    Hydroxyl radical reaction rate constant = 2.6X10-11 cu cm/molec-sec at 25 °C (est)

    Hazard Identification

    Classification of the substance or mixture

    Acute toxicity - Category 1, Oral

    Skin irritation, Category 2

    Eye irritation, Category 2

    Reproductive toxicity, Category 2

    Specific target organ toxicity – repeated exposure, Category 1

    Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 2

    GHS label elements, including precautionary statements

    Pictogram(s)
    Signal word

    Danger

    Hazard statement(s)

    H300 Fatal if swallowed

    H315 Causes skin irritation

    H319 Causes serious eye irritation

    H361 Suspected of damaging fertility or the unborn child

    H372 Causes damage to organs through prolonged or repeated exposure

    H411 Toxic to aquatic life with long lasting effects

    Precautionary statement(s)
    Prevention

    P264 Wash ... thoroughly after handling.

    P270 Do not eat, drink or smoke when using this product.

    P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

    P203 Obtain, read and follow all safety instructions before use.

    P260 Do not breathe dust/fume/gas/mist/vapours/spray.

    P273 Avoid release to the environment.

    Response

    P301+P316 IF SWALLOWED: Get emergency medical help immediately.

    P321 Specific treatment (see ... on this label).

    P330 Rinse mouth.

    P302+P352 IF ON SKIN: Wash with plenty of water/...

    P332+P317 If skin irritation occurs: Get medical help.

    P362+P364 Take off contaminated clothing and wash it before reuse.

    P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

    P318 IF exposed or concerned, get medical advice.

    P319 Get medical help if you feel unwell.

    P391 Collect spillage.

    Storage

    P405 Store locked up.

    Disposal

    P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

    Other hazards which do not result in classification

    no data available

    Handling and Storage

    Precautions for safe handling

    Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

    Conditions for safe storage, including any incompatibilities

    Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

  • Seller Information
    Business Type:

    Trader

    Main Products:

    Medetomidine,Medetomidine hydrochloride,D-Lysergic Acid Methyl Ester,SR17018,Fluralaner,GS-441524

    Location:

    RONGSHENG BEIYUANDAJIE 9, LICHENG DISTRICT,JINAN, SHANDONG CHINA

    Payment Terms:

    TT against copy of documents,TT against B/L draft before shipment,100% TT in advance

    Average lead Time:

    7

    Total Annual Revenue:

    $1 million-$2.5 million

    Total Employees:

    11-50

    Year of Establishment:

    2022

    Jinan Topfull Chemical Co., Ltd. is a global chemical Industrial and focuses on advanced chemical technology. Specialized in Cosmetic materials, water treatment, fine chemicals and so on. We are looking forward to working together with the people of all circles at home and abroad to seek common development!
  • Inquiry History
    4 Inquiries
    Country Product Purchase Quantity Date Posted
    India

    Bortezomib

    100.00 G Jul 30, 2026
    United States

    Bortezomib

    1 G Sep 6, 2026
    Brazil

    Bortezomibe

    1.00 KG Mar 28, 2025
    India

    Bortezomib  

    1.00 KG Jul 12, 2024
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