Retatrutide (CAS 2381089-83-2)|99% Purity|Research Grade Peptides|Purity tested by renowned testing laboratories

Retatrutide is a first-in-class triple agonist peptide that simultaneously activates the Glucose-dependent Insulinotropic Polypeptide receptor (GIPR), Glucagon-Like Peptide-1 receptor (GLP-1R), and Glucagon receptor (GCGR). Engineered as a 39-amino-acid peptide based on native GIP with Aib substitutions at positions 2 and 20, a C20 fatty diacid modification at Lys17 via a gamma-Glu-(AEEA) linker, and C-terminal amidization, Retatrutide achieves an extended plasma half-life of approximately 6 days through albumin binding

As a research reagent, Retatrutide is intended for in vitro and in vivo metabolic research, including studies of obesity, type 2 diabetes, non-alcoholic steatohepatitis (NASH), and cardiometabolic syndrome. The triple receptor activation profile provides synergistic effects on appetite suppression, insulin sensitization, energy expenditure, and lipid mobilization that exceed what single or dual receptor agonists can achieve.

Retatrutide binds to all three human receptors with high potency:

• GIPR EC₅₀: 0.064 nM — Enhances glucose-dependent insulin secretion, improves pancreatic beta-cell function, modulates adipose tissue lipid metabolism

• GLP-1R EC₅₀: 0.775 nM — Promotes glucose-dependent insulin release, suppresses glucagon secretion, delays gastric emptying, reduces appetite through CNS pathways

• GCGR EC₅₀: 5.79 nM — Increases energy expenditure and hepatic glucose output, enhances lipolysis, promotes fatty acid oxidation

Mechanism summary:

• Appetite Suppression: GLP-1 and GIP activation in the hypothalamus reduces hunger and increases satiety

• Delayed Gastric Emptying: Slows food leaving the stomach, prolonging post-meal fullness

• Increased Energy Expenditure: Glucagon activation raises resting metabolic rate and promotes thermogenesis

• Enhanced Lipolysis: Glucagon signaling stimulates fat breakdown and fatty acid oxidation

• Insulin Sensitization: GIP activation improves insulin sensitivity in peripheral tissues

Retatrutide has demonstrated remarkable metabolic improvements across Phase II and Phase III clinical trials (TRIUMPH program):

Weight Loss:

• Phase III TRIUMPH-1: 12mg dose — average 28.3% weight loss (70.3 lbs) over 80 weeks

• 104-week extension: average 30.3% weight loss (85 lbs), approaching bariatric surgery efficacy

• 65.3% of participants achieved BMI below 30 (no longer obese)

Glycemic Control:

• HbA1c reduced by up to 2.2% in T2D patients

• 82% of T2D participants reached HbA1c ≤ 6.5%

Liver Health:

• Over 80% reduction in liver fat content (NAFLD/NASH)

Comorbidity Relief:

• Knee osteoarthritis pain reduced by up to 73% (WOMAC score)

• Obstructive sleep apnea improved by 60.6% (AHI reduction)

Cardiometabolic:

• Reduced blood pressure, triglycerides, LDL cholesterol, waist circumference, and inflammatory markers

* Data from published Phase II and Phase III clinical trials. Product is investigational. For research reference only.

• Obesity & Energy Metabolism Research: In vivo studies of weight regulation, appetite control, and energy expenditure in rodent and primate models

• Type 2 Diabetes Studies: Investigation of glucose homeostasis, insulin secretion, and beta-cell preservation

• NASH / NAFLD Research: Evaluation of hepatic steatosis reduction, liver inflammation, and fibrosis markers

• Cardiometabolic Research: Studies of lipid profiles, blood pressure, and cardiovascular risk markers

• Receptor Pharmacology: In vitro characterization of triple receptor signaling, cAMP assays, and receptor binding studies

• Peptide Drug Development: Reference compound for next-generation multi-target agonist design and formulation studies

✓ Triple agonist targeting GIPR, GLP-1R, and GCGR receptors
✓ ≥99% purity verified by HPLC, independently tested by FREEDOM or JANOSHIK
✓ Lyophilized powder in sterile glass vials, 10 vials per box
✓ Available in 5mg, 10mg, 20mg, 30mg, 40mg per vial
✓ Customizable cap colors available for bulk orders

Global Air Shipping · Door-to-Door Delivery

All research reagents are shipped via air freight with professional packaging. Orders dispatch within 3 days, with door-to-door delivery directly to your lab or office.

Shipping Method: Air Freight

Delivery: Door-to-Door

Dispatch Time: Within 3 days of order

Packaging: Professional secure packaging

Customizable Cap Colors

13mm aluminum-plastic caps (6.2mm inner height) with four finish options — matte, glossy, OFF, and tear-off — in 30+ colors. Meet your brand differentiation and product line identification needs.

• Cap Size: 13mm Aluminum-Plastic

• Finishes: Matte / Glossy / OFF / Tear-off

• Colors: 30+ Available

• Packaging: 10 vials / tray / box

* MOQ for custom colors — please consult our sales team.

Precautions

• This product is for research use only 

• Allow vials to equilibrate to room temperature before opening to prevent condensation from affecting product stability

• Reconstitute with appropriate buffer or sterile water according to experimental protocols. Prepare fresh solutions when possible

• Dispose of unused product and packaging in accordance with local regulations for chemical/biological waste.

Q1. How do you ensure product quality?

A1. Each product is independently tested by FREEDOM or JANOSHIK third-party laboratory according to product type, including HPLC purity analysis (≥99%), LC-MS/MS mass spectrometry verification.

Q2. Why buy from us instead of other suppliers?

A2. We are a direct manufacturer offering competitive prices and guaranteed quality. We support customizable cap colors, provide fast air shipping with door-to-door delivery, and deliver honest, timely, and efficient service with extensive experience in domestic and foreign trade. Our products are independently verified by world-class third-party testing laboratories (FREEDOM or JANOSHIK).

Q3. How to place an order?

A3. Contact our sales Lev via WhatsApp (+852 5172 9003) or email (lechumrinhus867@gmail.com) with your requirements including product, size, and quantity. We will send a complete quotation including freight. After confirming the order and receiving payment/deposit, we arrange delivery within 3 days upon receiving the bank receipt.

Q4. Do you have stock?

A4. We keep stock for most standard products and sizes. For some rare products or custom specifications, additional synthesis time is required. Contact our sales team for current stock availability.

Q5. What is your MOQ?

A5.  the minimum order is 1 box (10 vials). Available sizes: 5mg, 10mg, 20mg, 30mg, and 40mg per vial. Larger quantities and custom sizes are available — contact sales for bulk pricing.

Q6. Is there a discount for bulk orders?

A6. Yes, different quantities qualify for different discount tiers. Larger orders always receive better pricing. Contact our sales team for a tailored quotation based on your specific needs.

Q7. Can you provide custom synthesis or modified peptides?

A7. Yes, we offer custom peptide synthesis including sequence modifications, different fatty acid chain lengths, alternative linker chemistries, and various packaging options. Contact our technical team with your specifications for a custom quote.

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