Product Overview
6,6‑Dimethyl‑4,5,6,7‑tetrahydro‑2H‑indazole‑3‑carboxylic acid (CAS 581083‑30‑9) is a high‑purity heterocyclic building block featuring a fused indazole ring system with a dimethyl‑substituted tetrahydropyridazine moiety. This compound is widely utilized in medicinal chemistry and pharmaceutical intermediate research, particularly in the synthesis of kinase inhibitors and other biologically active small molecules. It appears as an off‑white to white crystalline powder. The product is soluble in polar organic solvents such as dimethyl sulfoxide and dimethylformamide, with limited aqueous solubility. Supplied at ≥98.0% purity as determined by HPLC, this research‑grade reagent is manufactured under strict quality control to ensure batch‑to‑batch consistency. It is intended exclusively for scientific research purposes and is not for human consumption or clinical use.
Synthetic Process
The synthesis typically involves a multi‑step cyclization route starting from substituted cyclohexanone derivatives. Key steps include hydrazine condensation, followed by cyclization and carboxylation to yield the target indazole carboxylic acid. The crude product is purified by recrystallization or column chromatography to achieve ≥98.0% purity.
Mechanism of Action
As a synthetic intermediate, this compound does not exert a direct pharmacological mechanism of action. Its chemical structure and functional groups make it a valuable precursor for:
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Kinase Inhibitor Synthesis: The indazole core is a privileged scaffold in the design of protein kinase inhibitors for oncology research.
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Medicinal Chemistry: Used as a building block for the preparation of diverse compound libraries in drug discovery programs.
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Agrochemical Research: Indazole derivatives are also explored for their potential as crop protection agents.
Quality Specifications
| Parameter | Specification | Test Method |
| Appearance | Off‑white to white crystalline powder | Visual inspection |
| Assay (Purity) | ≥98.0% | HPLC area normalization |
| Melting Point | ≥260 °C (dec.) | Capillary method |
| Water Content | ≤0.5% | Karl Fischer titration |
| Residue on Ignition | ≤0.1% | Gravimetric analysis |
| Heavy Metals | ≤20 ppm | ICP‑MS / AAS |
| Identification | Conforms to structure | ¹H‑NMR, ¹³C‑NMR, MS |
| Residual Solvents | Meets ICH Q3C guidelines | GC headspace analysis |
| Shelf Life | 24 months from date of manufacture | When stored under recommended conditions |
Packaging & Shipping
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Research quantities: Available in 1g, 5g, 10g, and 25g amber glass vials with PTFE‑lined caps.
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Bulk quantities: Available in 50g, 100g, 500g, and 1kg amber glass bottles.
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Custom packaging: Available upon request.
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Shipping conditions: This product is not classified as dangerous goods under international transport regulations. It can be shipped at ambient temperature for routine orders.
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Documentation: Each shipment includes a COA, MSDS, and commercial invoice.
Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.
Our company is committed to making every effort to provide ideal chemical products to potential customers worldwide, including but not limited to: organic/inorganic reagents, biological reagents, plant extracts, pharmaceutical intermediates, active pharmaceutical ingredients (APIs), reference standards, reference substances, peptides, and more. Meanwhile, we have established long-term and stable cooperative relationships with university laboratories and off-campus research institutions, enabling us to offer tailored product services based on customers' actual needs.
We currently support customized services for most product categories, with supply quantities ranging from milligram (mg), gram (g) to kilogram (kg) levels, as well as wholesale. Product purity covers the full spectrum from 90% to 99.9%, providing customers with one-stop convenient services.
To date, our products have been exported to developed countries such as the United States, Australia, Canada, Mexico, as well as EU member states including France, Germany, and many other countries and regions such as Nigeria, Ghana, Southeast Asia, and other parts of Asia. Our product quality and services have consistently received high praise.
Looking ahead, our company will continue to serve as a bridge connecting China and the world, delivering high-quality products and services to global customers .
