High Purity 99% MOTS-c Peptide Raw Powder with ready stock,for laboratory research only

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MOTS-c More Info

MOTS-c is a mitochondrial-derived peptide (MDP) that consists of 16 amino acids encoded by the short open reading frame (sORF) of the mitochondrial 12S rRNA gene. It has been identified as a novel regulator with significant biological functions, particularly in metabolic regulation, muscle homeostasis, and aging processes.

Mechanism of Action

MOTS-c functions through several mechanisms:
Regulation of Glucose Metabolism: It enhances glucose uptake in skeletal muscle, which is crucial for maintaining energy homeostasis. This effect is largely mediated through the activation of the AMP-activated protein kinase (AMPK) pathway, which plays a significant role in cellular energy regulation.
Mast Cell Stabilization: MOTS-c stabilizes mast cells and regulates the expression of nuclear genes involved in metabolism, particularly under conditions of metabolic stress.
Exercise Mimetic: The peptide is upregulated in response to physical exercise, suggesting it mimics some of the beneficial effects of exercise on metabolism and muscle function.

Applications

Diabetes Management: Its ability to improve insulin sensitivity makes it a candidate for treating type 2 diabetes.
Obesity Treatment: By enhancing glucose metabolism and promoting fat oxidation, MOTS-c could be beneficial in managing obesity.
Aging Research: Studies suggest that MOTS-c may help counteract age-related declines in metabolic function and physical capacity.

Routes of Administration

MOTS-c is typically administered through:
 Formulations: Often marketed for research purposes rather than clinical use.

Safety and Side Effects

Common Side Effects
While research on MOTS-c is still ongoing, some reported side effects include:
Increased heart rate or palpitations
 site irritation
Mild fever
Insomnia
Serious Side Effects
Serious adverse effects have not been extensively documented due to the limited clinical use of MOTS-c. However, potential risks associated with its use include:
Allergic reactions
Unknown long-term effects due to lack of comprehensive clinical trials
Precautions
MOTS-c is not approved for medical use and should be approached with caution. There are no established guidelines for its therapeutic application, and it is banned by the World Anti-Doping Agency (WADA) as of 2024.

Pharmacokinetics

Absorption and Distribution
As a peptide, MOTS-c is likely absorbed rapidly when . However, detailed pharmacokinetic data regarding its distribution and metabolism in humans are limited.
Metabolism and Excretion
Research on the metabolic pathways for MOTS-c is still evolving. Given its peptide nature, it may be broken down by proteolytic enzymes in the body.