Isorhamnetin 98% Purity CAS 480-19-3 Research Grade Flavonoid Reference Standard for Natural Product Analysis and Pharmacological Research

Product Overview

Isorhamnetin (CAS 480-19-3) is a naturally occurring flavonoid compound and an O‑methylated derivative of quercetin. It is a high‑purity research‑grade reference standard isolated from various plant sources, including Ginkgo biloba, Hippophae rhamnoides (sea buckthorn), and Opuntia ficus‑indica. The chemical structure is 3,5,7,4′‑tetrahydroxy‑3′‑methoxyflavone, with a methoxy group at the 3′ position replacing one of the hydroxyl groups found in quercetin. This compound exhibits a yellow crystalline appearance and is known for its potent antioxidant, anti‑inflammatory, and cardioprotective properties. As a reference standard, it is essential for the identification and quantification of isorhamnetin in herbal extracts and pharmaceutical formulations.

Synthetic Process / Isolation Method

Isorhamnetin is typically isolated from natural plant sources:

• Extraction: Dried plant material (sea buckthorn berries, ginkgo leaves) is extracted with ethanol or methanol.

• Hydrolysis: Glycosylated forms of isorhamnetin are hydrolyzed to release the free aglycone.

• Partitioning and Chromatography: The extract is subjected to liquid‑liquid extraction and column chromatography (silica gel, Sephadex LH‑20).

• Recrystallization: The purified compound is recrystallized to achieve ≥98% purity.

• Quality Confirmation: Characterized by HPLC, NMR, and MS.

Mechanism of Action

As a flavonoid compound, isorhamnetin exerts its biological activities through multiple mechanisms:

• Antioxidant Activity: Effectively scavenges free radicals, reduces oxidative stress, and protects cells from oxidative damage.

• Cardioprotective Effects: Improves endothelial function, reduces blood lipid levels, and protects against atherosclerosis.

• Anti‑inflammatory Activity: Suppresses pro‑inflammatory cytokine production and modulates inflammatory signaling pathways.

• Anticancer Potential: Induces apoptosis in cancer cells and inhibits tumor cell proliferation through modulation of various signaling pathways.

• Neuroprotective Effects: Protects neuronal cells from oxidative damage and may have therapeutic potential in neurodegenerative diseases.

Quality Specifications

Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.

Our company is committed to making every effort to provide ideal chemical products to potential customers worldwide, including but not limited to: organic/inorganic reagents, biological reagents, plant extracts, pharmaceutical intermediates, active pharmaceutical ingredients (APIs), reference standards, reference substances, peptides, and more. Meanwhile, we have established long-term and stable cooperative relationships with university laboratories and off-campus research institutions, enabling us to offer tailored product services based on customers' actual needs.

We currently support customized services for most product categories, with supply quantities ranging from milligram (mg), gram (g) to kilogram (kg) levels, as well as wholesale. Product purity covers the full spectrum from 90% to 99.9%, providing customers with one-stop convenient services.

To date, our products have been exported to developed countries such as the United States, Australia, Canada, Mexico, as well as EU member states including France, Germany, and many other countries and regions such as Nigeria, Ghana, Southeast Asia, and other parts of Asia. Our product quality and services have consistently received high praise.

Looking ahead, our company will continue to serve as a bridge connecting China and the world, delivering high-quality products and services to global customers .