Sodium propionate

96.06

96.018723

3566934

205-290-4

391O0PO49R|DK6Y9P42IN

0557

TSCA listed

DTXSID7021996

C84167

White

S - Sensory organs

29159000

40.1

-0.85370

DryPowder

1.51[at 20℃]

285-286 °C (lit.)

141.7°C at 760 mmHg

57.7ºC

995 g/L (20 ºC)

Store at RT.

0Pa at 20℃

ADI has not been subject to any specific restriction (FAO/WHO, 2001).LD50 5.1 g/kg (mouse, oral).GRAS (FDA, § 184.1784, 2000).

Not classified

at 100.00%. bland

SLIGHT CHEESE-LIKE FLAVOR

8-9.5 (10g/l, H2O, 20℃)

Deliquescent in moist air

Dust explosion possible if in powder or granular form, mixed with air.

Inert atmosphere,Room Temperature

NONH for all modes of transport

1

Xn

36/37-36/37/39-26-36

UF7525000

Xn

Dry. Well closed.

Stable. Incompatible with strong oxidizing agents. Hygroscopic.

P280

21-38-36/37/38

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Substances classified as antimycotics, when migrating from food-packaging material include sodium propionate.|Substance added directly to human food affirmed as generally recognized as safe (GRAS) when meeting specified requirements.|Sodium propionate used as a chemical preservative in animal drugs, feeds, and related products is generally recognized as safe when used in accordance with good manufacturing or feeding practice.

Combustible. Gives off irritating or toxic fumes (or gases) in a fire. Finely dispersed particles form explosive mixtures in air.

|Warning|H312 (84.21%): Harmful in contact with skin [Warning Acute toxicity, dermal]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P322, P332+P313, P337+P313, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 354 companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]|P264, P280, P305+P351+P338, and P337+P313

Use water in large amounts.

Combustible

SODIUM PROPIONATE IS NOT IRRITATING WHEN USED CLINICALLY AS DUSTING POWDER FOR CONTROL OF FUNGUS INFECTIONS.

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Wash away remainder with plenty of water.

Dry. Well closed.

Evaporation at 20 °C is negligible; a nuisance-causing concentration of airborne particles can, however, be reached quickly when dispersed.

NO open flames. PREVENT DISPERSION OF DUST. Prevent build-up of electrostatic charges (e.g., by grounding).

Use local exhaust.

Protective gloves.

Wear safety spectacles.

IN RATS, VITAMIN B12 PREVENTED GROWTH LOSS CAUSED BY SODIUM PROPIONATE.|SODIUM PROPIONATE EXERTED SIGNIFICANT PROTECTIVE EFFECT AGAINST AMMONIA INTOXICATION IN CHICKS WHEN ADMIN IP 7 HR PRIOR TO AMMONIUM ACETATE CHALLENGE. EFFECTIVE DOSES RANGED FROM 3-4 MMOLE/KG.

LD50 Mouse oral 6332 mg/kg|LD50 Mouse sc 2100 mg/kg|LD50 Rabbit skin 1640 mg/kg

MANY PROPRIETARY PREPARATIONS ARE AVAILABLE FOR TREATING DERMATOPHYTIC INFECTIONS, ESPECIALLY TINEA PEDIS (ATHLETE'S FOOT). THESE INCLUDE ... SODIUM PROPIONATE ...|CLINICALLY, MEDICATION: SODIUM PROPIONATE IS USED IN TREATMENT OF OTOMYCOSIS. IT IS ALSO USED IN TREATMENT OF EPIDERMOPHYTOSIS, BUT IT IS NOT AS EFFECTIVE AS MOST OTHER AGENTS FOR THIS CONDITION. IT IS NOT FUNGICIDAL, SO THAT OTHER HYGIENE MEASURES MUST BE EMPHASIZED. ... DOSE--TOPICAL, IN DOSAGE FORMS CONTAINING 0.5-10% OF SODIUM PROPIONATE.|MEDICATION (VET): ALTHOUGH SOME COWS FIND HIGH DOSAGE (250 G) UNPALATABLE & IT MAY LACK SUBSTANTIAL EFFECTIVENESS AS PROPHYLACTIC & THERAPEUTIC AGENT IN ACETONEMIA, IT IS A USEFUL ADJUNCT TO THERAPY & ITS BENEFICIAL EFFECTS ON MILK PRODUCTION HAVE BEEN ATTRIBUTED TO CONTROL OF SUBCLINICAL KETOSIS.|MEDICATION (VET): EFFECTIVE IN EARLY TREATMENT OF KETOSIS OF CATTLE OR AS FOLLOWUP TREATMENT AFTER DEXTROSE THERAPY OF THIS DISEASE.|For more Therapeutic Uses (Complete) data for SODIUM PROPIONATE (6 total), please visit the HSDB record page.

SRP: In an acidic medium propionic acid is rapidly absorbed.

INCORPORATION RATE OF SPECIFICALLY LABELED SODIUM PROPIONATE INTO METHYLMALONATE & TRICARBOXYLIC ACID CYCLE INTERMEDIATES STUDIED. INCORPORATION OF (14)C FROM SODIUM PROPIONATE INTO METABOLIC INTERMEDIATES BEYOND METHYLMALONATE WAS POSITIVELY CORRELATED WITH LIVER VITAMIN B-12 CONCN.|MICE RECEIVED IV LABELED SODIUM PROPIONATE. ANALYSIS OF TOTAL BODY FATTY ACIDS 12 MIN LATER SHOWED 89 & 11 OF THE LABELS TO BE INCORPORATED INTO ODD-NUMBERED & EVEN-NUMBERED FATTY ACIDS, RESPECTIVELY. RESULTS CONFIRMED PROPOSED DEMETHYLATION OF PROPIONIC ACID IN VIVO.

Rinse with plenty of water (remove contact lenses if easily possible).

Fresh air, rest.

Rinse skin with plenty of water or shower.

Prophyllin

Cough. Sore throat.

Redness. Pain.

Mold inhibitor-Baked goods, 80%; Feed grain preservative, 10%; and Misc, 10% (1983) /Sodium & Calcium propionate/

SODIUM PROPIONATE NF; PROPANOIC ACID, SODIUM SALT, HYDRATE|SODIUM PROPIONATE IS OFTEN COMPOUNDED WITH ANTIBIOTICS OR ANTISEPTICS.|Grades: National Formulary; Food Chemical Codex|Propionic acid and sodium propionate ... may be compounded together or with sodium caprulate ... Sodium propionate is used in proprietary preparations in concentrations of 1 to 5%.

Food, beverage, and tobacco product manufacturing|Propanoic acid, sodium salt (1:1): ACTIVE|Propanoic acid, sodium salt (2:1): INACTIVE|PROPIONATES ARE MORE ACTIVE AGAINST MOLDS THAN SODIUM BENZOATE, BUT HAVE ESSENTIALLY NO ACTIVITY AGAINST YEAST. THEY HAVE LITTLE ACTION /IN BAKED GOODS/ ... AGAINST BACTERIA WITH NOTABLE EXCEPTION OF THEIR ABILITY TO INHIBIT THE ORGANISM WHICH CAUSES ROPE. THE PH FOR OPTIMUM ACTIVITY OF PROPIONATES RANGES UP TO 5.0, ALTHOUGH IN SOME FOODS THEY ARE ACTIVE UP TO PH 6, OR SLIGHTLY HIGHER. ... IN CHEESE PRODUCTS ... /PROPIONATES/ ARE LIMITED TO 0.3%. PROPIONATES ARE NOT MENTIONED IN FOOD-ADDITIVE REGULATIONS OF WEST GERMANY, INDIA, PAKISTAN, PHILIPPINES, & SOUTH AFRICA BUT THEY ARE INCLUDED IN THOSE OF OTHER WEST EUROPEAN COUNTRIES ... AS WELL AS CANADA. /PROPIONATES/|... /IT IS/ BACTERIOSTATIC AGAINST NUMBER OF GRAM-POSITIVE COCCI.|MOST ACTIVE AT ACID PH|... /BLENDS/ READILY WITH EMULSIFYING AGENTS USED IN PROCESSED & BLENDED CHEESE, AS WELL AS WITH BASIC DOUGH INGREDIENTS & IN FILLING FOR PIES.|For more General Manufacturing Information (Complete) data for SODIUM PROPIONATE (7 total), please visit the HSDB record page.

AOAC Method 970.36. Propionates in food. /Total propionates/

EPA Safer Chemical Functional Use Classes -> Preservatives and Antioxidants;Processing Aids and Additives|Safer Chemical Classes -> Green circle - The chemical has been verified to be of low concern|Food additives|Agrochemicals -> Fungicides|Cosmetics -> Preservative

Food Additives -> PRESERVATIVE;