high quality β-NMN Nicotinamide ribotide NMN powder cosmetics intermediates

Nicotinamide Mononucleotide, also known as β-Nicotinamide Mononucleotide (NMN), is a naturally occurring bioactive nucleotide and an endogenous substance in the human body. It serves as a substrate for the synthesis of Coenzyme I and is also utilized in anti-aging research. Research indicates that β-NMN can regulate insulin secretion and influence mRNA expression levels, demonstrating broad application potential in medical therapeutics.

β-Nicotinamide mononucleotide is a product of extracellular nicotinamide phosphoribosyltransferase (eNAMPT) reactions and a key NAD+ intermediate. It improves glucose tolerance by restoring NAD+ levels in HFD-induced T2D mice. It also enhances hepatic insulin sensitivity and partially restores gene expression related to oxidative stress, inflammatory response, and circadian rhythm through SIRT1 activation.

Appearance: White or off-white crystalline powder with high purity (commonly ≥98%). Highly soluble in water.

(1) β-Nicotinamide Mononucleotide is a precursor to NAD+, the cofactor for longevity proteins in the human body. NAD+ serves as a vital coenzyme in the tricarboxylic acid cycle, promoting the metabolism of carbohydrates, fats, and amino acids while participating in energy synthesis. NAD+ is also the sole substrate for coenzyme I-consuming enzymes (the exclusive substrate for DNA repair enzyme PARP, longevity protein Sirtuins, and cyclic ADP-ribose synthase CD38/157). NAD+ is involved in virtually every aspect of human metabolism, serving as a crucial coenzyme. Without adequate NAD+, metabolic processes falter. As NAD+ levels decline with age, various health issues arise. Supplementing with NAD+ offers comprehensive anti-aging benefits.

(2)Preclinical studies demonstrate NMN's diverse pharmacological activities in conditions including cardiac and cerebral ischemia, Alzheimer's disease, diet- and age-induced type 2 diabetes, and obesity. As an NAD+ precursor, NMN primarily exerts its effects by promoting NAD+ synthesis in vivo—all of which are linked to NAD+ deficiency.

(1) Alleviating and Improving Ischemic Damage to Cardiac and Cerebral Tissue

Research indicates that supplementing with exogenous β-NMN increases NAD+ and NADH levels in the heart, mimicking the protective effects of IPC. This enhances deacetylase activity, reduces infarct size, and achieves cardioprotective effects. Abnormal cerebral blood circulation can trigger acute cerebrovascular disease, and β-NMN demonstrates ameliorative effects in such conditions.

(2) Improving Oxidative-Related Degenerative Diseases and Physical Dysfunction

Research indicates that β-NMN can more directly and effectively increase NAD+ levels, promoting the activation of the longevity factor Sirtuin. This reduces cellular damage, maintains collagen integrity, and prevents skin issues such as dryness, dehydration, sagging, laxity, and fine lines, thereby delaying skin aging. Cardiovascular diseases primarily result from irregular relaxation and contraction of myocardial cells. Therefore, treating these conditions requires repairing and enhancing mitochondrial energy within myocardial cells.

(3) Therapeutic Effects on Metabolic Disorders

β-NMN promotes NAD+ biosynthesis. Nampt-mediated NAD+ synthesis is crucial for cellular function, regulating insulin secretion in pancreatic cells to lower blood glucose levels.