high purity 5-amino-1MQ;NNMTi;5-Amino-1methylquinolinium iodide;Reddish-brown powder

  Product Detail  

1. Description​

5-Amino-1-methylquinolinium chloride, abbreviated as 5-Amino-1MQ (chloride form), is a synthetic small-molecule compound belonging to the class of quinolinium salt derivatives. Its chemical formula is C₁₀H₁₁ClN₂, and its CAS number is 42464-96-0. In the research market, it typically appears as a brown to reddish-brown powder with high purity (generally ≥99%) and good water solubility; it is suitable for storage at room temperature away from light. The reason this compound has attracted significant attention in the fields of metabolism and anti-aging research in recent years is that it has been found to precisely inhibit an enzyme in the human body called “nicotinamide N -methyltransferase” (NNMT)—an enzyme that serves as a key regulatory point influencing NAD+ (nicotinamide adenine dinucleotide) levels, energy metabolism, and fat storage in the body. Simply put, it is not a dietary supplement in itself, but rather a “tool for regulating metabolic switches.” By inhibiting the enzyme NNMT, it indirectly influences the body’s energy utilization, fat accumulation, and the aging process. Currently, it is primarily available on the market as a research-grade raw material and is commonly referred to as an NNMT inhibitor (NNMTi).

1. Application​

At the application level, the most established and mainstream use of 5-Amino-1MQ is currently as a research tool compound, helping researchers explore the relationships between NNMT and metabolism, NAD+, fat, and aging. Since its mechanism of action—“boosting NAD+ and promoting metabolism”—aligns closely with the currently booming anti-aging and sports nutrition sectors, it is gradually being incorporated into the development of dietary supplements and functional ingredients. Examples include anti-aging formulas combined with NMN and NR, muscle maintenance products for middle-aged and older adults, and sports nutrition ingredients designed to enhance endurance and combat fatigue. Furthermore, in the pharmaceutical sector, it is in the preclinical research stage for multiple indications, including obesity, metabolic diseases, organ fibrosis, and tumor immunology, and is regarded as a promising starting point for drug development. Overall, it represents an emerging product line that is gradually transitioning from a “research reagent” to “functional ingredients and drug development.”

1. Research Reagents: As a selective inhibitor of NNMT, it is widely used in research on metabolism, methylation, NAD+ pathways, lipid metabolism, and aging mechanisms, serving as a core tool compound in relevant laboratories.

2. Dietary Supplement Ingredients: Used in the development of NAD+-potentiating anti-aging health supplements (often combined with NMN, NR, etc.), formulations for managing sarcopenia in middle-aged and elderly individuals, and sports nutrition products designed to enhance endurance and combat fatigue.

3. Drug Research and Development: It is being explored as a potential drug candidate in preclinical studies targeting obesity, type 2 diabetes, chronic kidney disease fibrosis, and cancer (particularly in combination with immunotherapy).

4. Raw Material Trade and Product Development: It circulates in the international raw material market as a high-purity research/functional ingredient, typically labeled “For Research Use Only,” and is procured by downstream manufacturers and research institutions.

1. Main Efficacy​

Based on existing research, the efficacy of 5-Amino-1MQ revolves around the core mechanism of “inhibiting the NNMT enzyme.” By blocking NNMT’s “interception” of nicotinamide, it allows nicotinamide that would otherwise be consumed to be redirected toward NAD+ synthesis, thereby increasing NAD+ levels in the body; simultaneously, it also influences the metabolism of methyl donors and the energy pathways of fat cells. Based on this mechanism, it shows potential in multiple areas, including fat loss, metabolic improvement, anti-aging, and organ protection. However, it should be noted that these conclusions are currently derived primarily from preclinical studies at the cellular and animal levels, and there is a lack of large-scale human clinical trial data.

1. Boosting NAD+ Levels: By inhibiting NNMT, it “reclaims” the nicotinamide substrate for the NAD+ synthesis pathway, helping to increase NAD+ concentrations in the body and laying the foundation for cellular energy metabolism and anti-aging.

2. Promoting Fat Metabolism and Aiding Fat Loss: It inhibits adipocyte differentiation and reduces adipocyte volume, prioritizing the reduction of visceral fat in the waist and abdomen as well as stubborn fat, while simultaneously increasing energy expenditure—and it does so without relying on appetite suppression or affecting food intake.

3. Improves metabolic health: Animal studies show that it improves blood glucose and lipid profiles (e.g., by lowering total cholesterol) and has a positive regulatory effect on metabolic disorders.

4. Anti-aging and improved muscle function: Helps combat age-related muscle loss (sarcopenia), promotes the proliferation and repair of muscle stem cells, and improves muscle mass and physical fitness in older adults.

5. Organ Protection and Anti-Fibrosis: In chronic kidney disease models, it has been shown to reduce renal fibrosis, delay tubular aging, and improve kidney function.

6. Antitumor Potential: Since NNMT is overexpressed in various cancer cells, inhibiting NNMT may suppress tumor growth, metastasis, and drug resistance, and is expected to enhance the response to immunotherapy.