Enable Efficient Gene Transfer and Intracellular Delivery with This Advanced Cell-Penetrating Peptide Vector

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TG20 — Cell-Penetrating & Gene Delivery Peptide

TG20, also known as ppTG20, is a 20-residue amphiphilic cell-penetrating peptide belonging to the KALA family. This synthetic peptide functions as a single-component gene transfer vector, representing a significant advancement in nucleic acid delivery technology. Unlike traditional multi-component lipid transfection reagents that introduce formulation variability and endosomal entrapment issues, TG20 offers a streamlined and efficient approach to intracellular delivery.

The compound binds directly to nucleic acids, eliminating the need for helper lipids such as DSPC and cholesterol. This single-component design simplifies formulation and reduces variability between experiments. TG20 demonstrates pH-independent membrane destabilization activity, functioning effectively at both pH 5 and pH 7, which helps overcome the endosomal escape bottlenecks that plague many gene delivery systems.

This characteristic is particularly valuable for hard-to-transfect cell types where traditional methods often fail.

Research has validated TG20's efficacy in delivering nucleic acids to target tissues, with demonstrated in vivo pulmonary luciferase expression following administration. The peptide's well-defined sequence enables structure-activity relationship studies and rational design of antimicrobial analogues. TG20 is available for preclinical research programs including lung disease studies, vaccine development, and antimicrobial discovery.

TG20's molecular formula and defined structure provide researchers with a reliable and reproducible tool for gene therapy research, siRNA delivery, and nucleic acid-based therapeutic development. Whether you are exploring non-viral gene delivery approaches, developing novel vaccine strategies, or investigating intracellular delivery mechanisms, TG20 offers a sophisticated and validated platform for advancing your research.

Product Packing:10mg/10vial;20mg/10vials;30mg/10vials;60mg/10vials

Shipping Condition:Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

When storing peptides, remember to:

• Store peptide in a cold, dry, dark place

• Avoid repeated freezing and thawing of peptide

• Avoid overexposure to the air • Avoid light exposure

• Avoid storing peptides in solution long term

We can also recomend you the best shipping method to let you receive the products more safely and faster.