Sales Manager：Grace

WhatsApp / WeChat：+8615533197069

Email：Grace@hzzmtrade.com

1. 1.We support large‑scale production and offer customized solutions.
2. 2.Bottle dimensions and milligram filling volumes can be adjusted to meet your requirements.
3. 3.Safe and reliable shipping channels are available.
4. 4.All vials go through vacuum‑sealing treatment.
5. 5.Brand‑new fresh batches are produced every 6‑8 days.

Quality Control: Our products are manufactured in GMP‑certified facilities with full‑process traceability, and supporting documents comply with relevant regulatory standards.

Supply Capacity: A wide range of product specifications are available. We maintain stable lead times and flexible production capacity to adapt to different orders.

Price Benefits: Direct factory‑sourced quotations with discounts for bulk purchases. A well‑functioning stable supply chain caters to diverse market order requirements.

Support Services: Complete sets of documentation are provided, alongside professional technical guidance for formulations.

Cagrilintide is an innovative long-acting amylin analogue that acts as a dual agonist of both amylin receptors and calcitonin receptors, regulating appetite and energy metabolism through a unique mechanism. It is primarily used in research on weight management for obesity and overweight populations, while demonstrating significant synergistic effects on glycemic control when combined with GLP-1 receptor agonists. The Phase 3 clinical trial REDEFINE 1 confirmed that after 68 weeks of treatment, the Cagrilintide 2.4 mg dose group achieved an average weight reduction of 11.8%, with an overall favorable tolerability profile, offering a novel approach for research into metabolic disorders.

Appetite and Satiety Central Regulation: Multiple preclinical studies have demonstrated that Cagrilintide exerts significant appetite-suppressing and satiety-enhancing effects by activating Calcr/Prlh neurons in the area postrema and the nucleus tractus solitarius (NTS). It modulates neurotransmitter release and synaptic activity, thereby stabilizing energy intake balance at the neural regulatory level, offering a novel target for intervention research on obesity-related appetite disorders.

Body Weight and Body Composition Optimization: As a long-acting amylin analogue, Cagrilintide maintains relatively lean body mass while reducing body weight, primarily achieving weight loss through fat mass reduction. The Phase 3 clinical trial REDEFINE 1 showed that Cagrilintide 2.4 mg monotherapy for 68 weeks resulted in an average weight reduction of 11.8% in obese or overweight patients, with the weight-loss effect being dependent on the presence of AMY1R and AMY3R receptor subtypes.

Intervention Potential in Diabetic Complications: Preclinical studies have found that in animal models of diabetic kidney disease, Cagrilintide significantly elevates cAMP levels within renal cortical tubules and affects the modification status of ion transporters such as NKCC2 and NCC, suggesting a specific mechanism of action in renal physiological regulation in diabetes. Additionally, a Phase 2 clinical trial is currently underway in patients with type 2 diabetes complicated by painful diabetic peripheral neuropathy to evaluate the efficacy of CagriSema (Cagrilintide in combination with semaglutide) in improving neuropathic pain in this patient population.

Skeletal Muscle Mitochondrial Function Regulation: In vitro studies have shown that Cagrilintide exerts a time-dependent regulatory effect on skeletal muscle mitochondrial respiratory function—transiently reducing basal oxygen consumption rate and ATP synthesis within 48 hours, with this effect being reversible within 5 days. This dynamic modulation pattern reveals its unique regulatory characteristics at the cellular energy metabolism level, providing a new observational dimension for research on metabolic adaptability.

As a cutting-edge long-acting amylin analogue raw material, Cagrilintide is widely used in research on the mechanisms of obesity and type 2 diabetes, metabolic regulation interventions, and the development of novel multi-target combination therapies. Cagrilintide acts as a dual agonist of amylin receptors (AMYRs) and calcitonin receptors (CTR), exerting significant appetite-suppressing effects by activating relevant neurons in the area postrema and nucleus tractus solitarius, while also delaying gastric emptying and enhancing satiety. When combined with GLP-1 receptor agonists such as semaglutide, the two agents synergistically regulate glucose metabolism and energy balance through complementary mechanisms—semaglutide promotes insulin secretion, while Cagrilintide may enhance insulin sensitivity. This raw material is primarily applied in various scientific research settings, covering investigations into obesity pathogenesis, glycemic regulation in type 2 diabetes, metabolic-related cardiovascular risk exploration, as well as the development and preclinical evaluation of amylin-GLP-1 dual-target combination therapeutics.

Our company focuses on the R&D and supply of various peptide products. Our main product line includes weight‑loss peptides, anti‑wrinkle peptides, tanning peptides and other peptide raw materials, and we also accept customized peptide product requests. The company has established a complete quality management system with strict quality‑control standards, supported by thoughtful one‑stop customer services. Our experienced team is ready to deliver professional support to fully meet diverse procurement requirements from global clients.

We put customer value at the heart of our business. We stick to high‑product standards while maintaining competitive pricing. Flexible order quantities are supported, and we closely monitor production and lead times to ensure on‑time delivery for every order. Our products are mainly exported to key overseas markets including Europe, the United Kingdom, the United States, Canada and Australia. Thanks to consistent product quality and reliable service systems, we have gained wide recognition and trust from customers worldwide.

We have built mature in‑house cross‑border distribution channels covering the United States, Canada, the United Kingdom, Spain, Poland, the Netherlands, Germany, Russia, Kazakhstan and other regions. Door‑to‑door one‑stop delivery is available with streamlined customs clearance, eliminating customs‑related issues and enabling hassle‑free receipt of goods for customers.

Strict internal controls are implemented across the whole workflow, from raw‑material selection and production to logistics delivery. Only high‑purity, premium‑grade raw materials are adopted. Guided by the core philosophy of “survive by quality, grow by reputation”, we supervise every production procedure to guarantee stable product quality from the source.

We possess distinctive product and service strengths: safe and efficient production technology balances consistent quality and fast turnaround. Sample testing services are offered prior to formal bulk orders for customers to verify product performance. With years of experience serving overseas markets, we provide cost‑effective goods together with comprehensive after‑sales support to resolve all kinds of cooperation‑related issues efficiently. We aim for full customer satisfaction and strive to build a trustworthy international brand.

Going forward, we will keep focusing on the R&D and manufacturing of high‑quality products, optimize pricing structures, improve professional technical and commercial support, and build a highly efficient team. Upholding the principle of integrity and win‑win partnership, we will continuously upgrade after‑sales services to maximize value for every partner.