IGF-1 LR3 Peptides Raw materials Wholesale price Reduced weight peptide 99% purity Factory direct sale

Insulin-like growth factor-1 (IGF-1, often labeled IG01 in export markets) is a single-chain active polypeptide composed of 70 molecules, with CAS number 946870-92-4. It belongs to the core signaling molecule superfamily and participates in cell proliferation and metabolic regulation. Natural IGF-1 is mainly obtained through synthesis and secretion. Simultaneously, IGF-1 can be locally secreted or paracrine in most tissues, including bone, muscle, and cartilage, participating in the physiological regulation of multiple systems throughout the body. High-purity IGF-1 lyophilized powder is artificially synthesized under solid-phase conditions and is a core research tool peptide in fields such as biology, endocrinology, tissue repair, mechanistic and metabolic medicine. Due to its stable biological activity and well-defined mechanism of action, it has become a commonly used raw material for basic research in laboratories worldwide.

From a physicochemical perspective, the molecular weight of the synthesized IGF-1 peptide is approximately 7.65 kDa. High-performance liquid chromatography (HPLC) analysis shows that the purity of this research-grade product is ≥98%. It is a pure white, loose, lyophilized powder with excellent water solubility, rapidly dissolving in sterile ultrapure water, PBS buffer, and other commonly used research solvents, suitable for various in vitro culture and in vivo animal drug delivery experiments. Standard storage conditions are -20°C, sealed, protected from light, and kept dry. Powdered IGF-1 exhibits extremely high activity stability and can be stored for long periods. However, the activity of IGF-1 is susceptible to decrease due to temperature and repeated freeze-thaw cycles. Therefore, research experiments typically employ ready-to-use powder preparation methods for aliquoting and cryopreservation. Compared to common methods, IGF-1 offers more precise target localization, clearer signaling pathways, and easier control of experimental variables. It effectively avoids experimental interference caused by imbalance factors, exhibits high reproducibility, and is suitable for high-precision basic research and mechanism verification experiments.

Regulating apoptosis is the most core and deeply studied scientific function of IGF-1, and its most fundamental biological value. IGF-1 specifically binds to the IGF-1R receptor on the cell membrane surface, activating key downstream signaling pathways such as PI3K/Akt and MAPK, thereby comprehensively regulating the cell life cycle. In vitro experiments have shown that IGF-1 can significantly promote the proliferation and differentiation of various somatic cells and stem cells, and accelerate cell growth under adverse conditions such as nutrient deprivation. Numerous studies have confirmed that IGF-1 can maintain cell viability, improve cell survival rate, and delay aging. Therefore, IGF-1 is widely used in the optimization of cell culture systems, stem cell expansion, and research on cell damage repair mechanisms, becoming an important active additive and mechanistic research tool in biological laboratory cell culture.

Somatic cell tissue growth and repair are classic research directions for IGF-1, covering metabolic studies of various tissues including bone, skeletal muscle, cartilage, and skin. In bone research models, IGF-1 is a core regulator of bone metabolic homeostasis. It directly promotes osteoblast formation and differentiation, improves bone matrix synthesis efficiency, and moderately inhibits excessive activation of osteoclasts, reducing bone resorption, thereby maintaining the dynamic balance between bone formation and bone resorption. In animal models of osteoporosis, bone defects, and skeletal developmental delay, IGF-1 intervention effectively increases bone mineral density, optimizes bone microstructure, and promotes bone repair and regeneration, making it a core experimental material for basic orthopedic research, bone development mechanisms, and bone injury repair.

In muscle metabolism studies, IGF-1 exhibits significant anabolic regulatory properties. Experimental data show that IGF-1 can promote skeletal muscle cell proliferation.