L-Rhamnose 98% Purity CAS 3615-41-6 Research Grade Monosaccharide Reference Standard for Natural Product Analysis and Carbohydrate Chemistry

Product Overview

L‑Rhamnose (CAS 3615‑41‑6) is a naturally occurring deoxy monosaccharide with the molecular formula C₆H₁₂O₅ and a molecular weight of 164.16 g/mol . It is a methyl‑pentose sugar (6‑deoxy‑L‑mannose) that is widely distributed in plant glycosides, bacterial polysaccharides, and various natural products . Unlike most naturally occurring sugars which exist in the D‑form, L‑rhamnose is one of the few naturally occurring L‑form sugars, along with L‑fucose and L‑arabinose . The compound appears as a white crystalline powder with a melting point of 91‑95°C and a solubility of 521.5 g/L in water at 40°C . It exhibits two crystalline forms: α‑type (monohydrate) and β‑type (anhydrous). The α‑type contains one molecule of water of crystallization, which is lost upon heating to yield the β‑type, which is highly hygroscopic and reverts to the α‑type upon exposure to air . As a high‑purity reference standard, L‑rhamnose is essential for the identification and quantification of rhamnose‑containing compounds in natural product research, carbohydrate chemistry, and pharmaceutical analysis. The compound is supplied at ≥98.0% purity and is intended for research purposes only.

Synthetic Process / Isolation Method

L‑Rhamnose is typically isolated from natural sources through the hydrolysis of plant glycosides such as quercitrin (from lemon flavin) and naringin (from grapefruit processing waste), or obtained through microbial fermentation processes . The isolation involves acid hydrolysis, extraction, and purification steps to achieve the desired purity. The final product is rigorously characterized by HPLC (purity ≥98%), NMR, and mass spectrometry to confirm structural identity and purity.

Mechanism of Action / Application Principles

As a fundamental carbohydrate and research reagent, L‑rhamnose serves multiple important functions:

• Intestinal Permeability Marker: L‑Rhamnose is used to measure intestinal permeability, as it crosses the epithelium via the transcellular pathway and serves as a marker of intestinal absorption . It is commonly used in the lactulose/mannitol (or rhamnose) intestinal permeability test to assess gut barrier function.

• Microbiological Substrate: It serves as a carbon source for various microorganisms in experimental applications and is commonly used as a substrate in microbiological and biochemical research to study the metabolism and growth of specific bacteria and fungi .

• Biological Activities: Rhamnose has been shown to induce browning in white adipocytes, activate brown adipocytes, enhance the immunogenicity of tumor‑associated antigens, and stimulate biofilm formation in certain bacteria . Rhamnose‑immunogen conjugates are also being explored for immunotherapy applications .

• Research Applications: In analytical chemistry and natural product analysis, L‑rhamnose serves as a reference standard for the identification and quantification of rhamnose‑containing glycosides and polysaccharides .

Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.

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We currently support customized services for most product categories, with supply quantities ranging from milligram (mg), gram (g) to kilogram (kg) levels, as well as wholesale. Product purity covers the full spectrum from 90% to 99.9%, providing customers with one-stop convenient services.

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