TB500 China origin is mainly used for anti-fibrosis and wound repair research, High Purity 99%CAS#885340-08-9 TDS

Product Overview

TB500, also known as thymosin β-4 (Tβ4) fragment, CAS number 144946-63-2, is a highly active synthetic regenerative peptide widely used in modern biomedical and pharmacological research. As an important research-grade raw material, TB500 features stable molecular structure, excellent bioactivity, and batch-to-batch stability, making it a core substance for tissue repair research, consistency studies of inflammation-regulating peptides, exploration of cell migration mechanisms, and the development of regenerative medicine peptides. Our TB500 product is a high-purity lyophilized white powder, produced using advanced solid-phase peptide synthesis technology and a multi-stage preparative HPLC purification process. Each batch is manufactured strictly according to international research-grade quality standards, with an HPLC purity of no less than 99%. Each batch comes with complete testing documentation, including Certificate of Analysis (COA), HPLC spectra, MS identification, moisture content testing, and residual impurity detection, fully meeting the experimental standards of laboratories, pharmaceutical institutions, and research teams worldwide.

Basic Product Specifications and Structural Characteristics

TB500 is a bioactive peptide fragment derived from natural human thymosin β-4 protein, retaining the core active sequence that governs tissue repair and cell regulation. Compared to full-length thymosin protein, this optimized fragment exhibits higher stability, stronger biological targeting, and lower degradation rate in experimental environments, effectively improving the reproducibility and accuracy of research data. This product utilizes vacuum freeze-drying technology to lock in bioactivity, has low moisture content, strictly controls insoluble impurities, and exhibits excellent solubility in sterile antimicrobial water and standard laboratory buffer solutions. All raw material production processes follow standardized purification procedures to thoroughly remove residual solvents, unreacted monomers, and intermediate impurities. Each batch of product undergoes rigorous quality testing, meeting the research-grade standards of the United States Pharmacopeia (USP) and the European Pharmacopoeia (EP), supporting flexible procurement from small-sample testing to large-scale industrial research applications.

Core Biological Functions and Mechanism of Action

TB500 exerts its powerful regenerative and regulatory effects through multiple targeted biological pathways, participating in cytoskeleton regulation and tissue remodeling based on its unique actin-binding properties. Its core mechanism involves binding to intracellular G-actin monomers, regulating the balance between actin polymerization and depolymerization, and assisting cells in completing cytoskeleton reconstruction. This core activity enables cells to rapidly adjust their morphology, accelerate directional migration, and efficiently aggregate in damaged tissue areas, laying the foundation for tissue repair and wound healing.

In terms of tissue repair and wound regeneration, TB500 significantly accelerates the migration and proliferation of keratinocytes, endothelial cells, and fibroblasts. It effectively promotes the repair of superficial skin trauma, soft tissue injury, muscle fiber injury, and vascular tissue injury, shortens the wound healing cycle, and reduces the risk of scar hyperplasia during tissue reconstruction. Simultaneously, TB500 effectively stimulates angiogenesis, promotes the formation of new microvessels in damaged tissue, improves local blood circulation, delivers sufficient oxygen and nutrients to the repair area, further optimizes the tissue regeneration environment, and improves repair efficiency.

In terms of inflammation regulation, TB500 exhibits excellent bidirectional regulatory performance. It can inhibit excessive inflammatory responses caused by tissue damage, reduce the release of pro-inflammatory factors, alleviate local tissue edema, exudation, and inflammatory pain, and avoid delayed healing or tissue fibrosis caused by persistent inflammation. Simultaneously, it does not interfere with the body's normal immune defense mechanisms, maintaining a balance between immune and inflammatory responses, which is crucial for standardized research on the repair of chronic inflammatory injuries.

Furthermore, preclinical studies have extensively confirmed that TB500 possesses multiple potential biological functions, including enhancing the repair capacity of muscle tissue after sports injuries, protecting endothelial tissue, delaying tissue aging, and promoting the repair of minor visceral injuries. Its multi-pathway regulatory properties make it a popular research molecule in regenerative medicine, sports pharmacology, skin repair biology, and anti-aging research.

Main Research Applications

TB500 exhibits stable activity and comprehensive repair regulatory functions, thus it is widely used in various professional scientific research fields.

FAQ

1. How do you ensure product quality?

We have a strict quality management system, all batches must be tested and meet our standards before entering the warehouse. The purity of all our products is above 99.00%, which has been verified by many American and European customers.

2. How to place an order with you?

After confirming the dosage/strength and quantity of the required product with the customer, our business personnel will make a Proforma Invoice or Sales Contract. After the customer confirms and pays for the order, we will arrange shipment for the customer as soon as possible.

3. What payment methods are there?

There are Bank Transfer, Wise, Revolut, Tether USD(USDT) and Bitcoin; we can also accept payments in CNY, for example, through Alipay or WeChat.

4. What shipping methods can we choose?

Usually express delivery is more suitable, including DHL, FedEx, UPS, etc. For Russia, we also have a dedicated express channel (double customs clearance). We will be responsible for customs clearance in the destination country, and customers are not required to cooperate with customs clearance and pay any tariffs.