High Purity Tirzepatide Lyophilized Powder CAS 2023788-19-2 Synthetic GLP-1/GIP Dual Agonist Peptide for Preclinical Research

Product Introduction

Tirzepatide is a synthetic 39‑amino‑acid modified peptide, dual GIP/GLP‑1 receptor agonist. Supplied as lyophilized powder for life‑science laboratory research. It is studied for incretin signaling, metabolic pathway and related pre‑clinical investigations.

Chemical Information

• Product Name: Tirzepatide
• Synonyms: LY3298176
• CAS No.: 2023788‑19‑2ECHEMI
• Molecular Formula: C₂₂₅H₃₄₈N₄₈O₆₈
• Molecular Weight: 4813.53 g/mol
• Sequence: Tyr‑{Aib}‑Glu‑Gly‑Thr‑Phe‑Thr‑Ser‑Asp‑Tyr‑Ser‑Ile‑{Aib}‑Leu‑Asp‑Lys‑Ile‑Ala‑Gln‑{diacid‑C20‑gamma‑Glu‑(AEEA)2‑Lys}‑Ala‑Phe‑Val‑Gln‑Trp‑Leu‑Ile‑Ala‑Gly‑Gly‑Pro‑Ser‑Ser‑Gly‑Ala‑Pro‑Pro‑Pro‑Ser‑NH₂
• Purity: ≥98%
• Appearance: White to off‑white lyophilized powder
• Solubility: Soluble in water and aqueous buffer solutions

Mechanism of Action

Tirzepatide is a dual‑receptor agonist that selectively binds and activates both GIP (glucose‑dependent insulinotropic polypeptide) receptor and GLP‑1 (glucagon‑like peptide‑1) receptor. Its C20 fatty‑diacid modification enables albumin binding to extend molecular half‑lifeFDA Access....

In pre‑clinical research models:

1. Pancreatic signaling: Stimulates glucose‑dependent insulin secretion from pancreatic β‑cells; suppresses glucagon release from α‑cells; modulates islet‑cell signaling pathwaysFDA Access
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3. Central nervous system: Acts on brain appetite‑regulating regions to modulate satiety and food‑intake related signaling pathways.
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5. Gastrointestinal effect: Delays gastric emptying in pre‑clinical assays, affecting post‑prandial nutrient handling.
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7. Peripheral metabolism: Modulates insulin‑sensitivity‑related signaling and lipid‑metabolism pathways in adipose and peripheral tissues in vitro and animal studies

Storage Condition

Lyophilized powder: Store at -20℃, sealed, dry, protected from light. Avoid repeated freeze‑thaw cycles. After reconstitution, keep at 2‑8℃ for short‑term use only.