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Home > Chemical Reagents > Organic Reagents > Dihexa for Sale > Dihexa (PNB-0408) CAS 1401708-83-5 | High Purity Nootropic Dipeptide
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Dihexa (PNB-0408) CAS 1401708-83-5 | High Purity Nootropic Dipeptide

TDS 172 Inquiries

Unit Price:

$50-60/G FOB

Get Latest Price
CAS No.:

1401708-83-5

Grade:

Reagent Grade

Content:

99%

Port:

qingdao

Brand:

//

Packaging:

1g/vial, 5g/vial, 25g/vial, 100g/vial

Price valid (until):

2026-10-09

Company Type:
Trader
Location:
China
Qualification:
Main Products:

Medetomidine,Medetomidine hydrochloride,D-Lysergic Acid Methyl Ester,SR17018,Fluralaner,GS-441524

  • Product Description

  • Seller Information

  • Inquiry History

  • Description

    —— Product Specifications ——



    —— Product Detail ——




                                                                                                                                                                          • Dihexa (PNB-0408) is a synthetic, metabolically stable angiotensin IV-derived peptidomimetic compound. Structurally optimized as a modified dipeptide (Hexanoyl-Tyr-Ile-Ahx-NH2), it was engineered to overcome the poor pharmacokinetic profile of its parent peptide — featuring an N-terminal hexanoyl cap and a C-terminal 6-aminohexanoic amide group that confer resistance to enzymatic degradation, oral bioavailability, and blood-brain barrier (BBB) permeability.

                                                                                                                                                                            Chemical Name: N-Hexanoic-Tyr-Ile-(6)-aminohexanoic amide
                                                                                                                                                                            CAS Number: 1401708-83-5
                                                                                                                                                                            Molecular Formula: C27H44N4O5
                                                                                                                                                                            Molecular Weight: 504.66 g/mol
                                                                                                                                                                            Appearance: White to off-white crystalline powder
                                                                                                                                                                            Purity: ≥98% (HPLC, batch-specific — refer to COA)
                                                                                                                                                                            Storage: Sealed, light-protected, 2-8 °C; long term -20 °C; hygroscopic, under inert atmosphere

                                                                                                                                                                            Key Features:
                                                                                                                                                                            • Orally active and BBB-permeable angiotensin IV analog
                                                                                                                                                                            • High-affinity interaction with hepatocyte growth factor (HGF)
                                                                                                                                                                            • Potent synaptogenic and neurotrophic activity in preclinical models
                                                                                                                                                                            • Protease-resistant with extended circulating half-life
                                                                                                                                                                            • ≥98% purity with batch-specific COA


    C ompany Profile ——


     ,

    Shop Amberlite IR-120 Cation Exchange Resin Sodium Form CAS 9002-23-7 High Purity Strong Acid Cation Exchange Resin for Water Softening, Demineralization,-Detailed Image 2

    Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.

    Our company is committed to making every effort to provide ideal chemical products to potential customers worldwide, including but not limited to: organic/inorganic reagents, biological reagents, plant extracts, pharmaceutical intermediates, active pharmaceutical ingredients (APIs), reference standards, reference substances, peptides, and more. Meanwhile, we have established long-term and stable cooperative relationships with university laboratories and off-campus research institutions, enabling us to offer tailored product services based on customers' actual needs.

    We currently support customized services for most product categories, with supply quantities ranging from milligram (mg), gram (g) to kilogram (kg) levels, as well as wholesale. Product purity covers the full spectrum from 90% to 99.9%, providing customers with one-stop convenient services.

    To date, our products have been exported to developed countries such as the United States, Australia, Canada, Mexico, as well as EU member states including France, Germany, and many other countries and regions such as Nigeria, Ghana, Southeast Asia, and other parts of Asia. Our product quality and services have consistently received high praise.

    Looking ahead, our company will continue to serve as a bridge connecting China and the world, delivering high-quality products and services to global customers.

     

    Shop Amberlite IR-120 Cation Exchange Resin Sodium Form CAS 9002-23-7 High Purity Strong Acid Cation Exchange Resin for Water Softening, Demineralization,-Detailed Image 3

    Shop Amberlite IR-120 Cation Exchange Resin Sodium Form CAS 9002-23-7 High Purity Strong Acid Cation Exchange Resin for Water Softening, Demineralization,-Detailed Image 4 

    —— Q&A ——

    Q1: How to confirm the product quality before placing orders?
    A: By sending you available samples. Or if you have special requirements for the goods, we can prepare samples according to your requirements for confirmation.

    Q2: Can you supply free samples?
    A: Yes, we can provide a free sample, but the shipping cost will be paid by the customers. You can either pay the shipping cost or arrange a courier to collect the samples.

    Q3: How do you treat quality complaints?
    A: All our products are strictly tested by our QC and confirmed by QA; unqualified material will not be released to customers. If any quality problem is confirmed to be caused by us, we will replace the goods or refund your payment immediately.

    Q4: What is your MOQ? Is there a discount?
    A: For highvalue products, our MOQ starts from 1g and generally starts from 10g. For other lowprice products, our MOQ starts from 100g and 1kg.
    Q: Is there a discount?
    A: Yes, for larger quantities, we always support with better prices.

    Q5: How to start orders or make payments?
    A: You can send us your Purchase Order (if your company has one), or just send a simple confirmation by email or via Trade Manager. We will then send you a Proforma Invoice with our bank details for your confirmation, and you can make payment accordingly. If you have other preferred payment methods, we are open to discussion and negotiation.



    ECHEMI Editorial Reference

    Dihexa is a synthetic peptide-based compound and angiotensin IV analog. As a research and pharmaceutical raw material, Dihexa is characterized by its defined molecular structure and peptide properties. It is primarily used for research, analytical testing, compound evaluation, and pharmaceutical development.

    Certificates
    • Dihexa (PNB-0408) CAS 1401708-83-5 | High Purity Nootropic Dipeptide Certificates 1 TDS

    Basic Info
    Product Name:

    Dihexa

    Other Name:

    L-Isoleucinamide,N-(1-oxohexyl)-L-tyrosyl-N-(6-amino-6-oxohexyl)-;N-(1-Oxohexyl)-L-tyrosyl-N-(6-amino-6-oxohexyl)-L-isoleucinamide;Dihexa;N-Hexanoic-Tyr-Ile-(6)aminohexanoic amide

    CAS No.:

    1401708-83-5

    Molecular Formula:

    C27H44N4O5

    InChIKeys:

    InChIKey=XEUVNVNAVKZSPT-JTJYXVOQSA-N

    Molecular Weight:

    504.7

    Exact Mass:

    504.66

    Categories:

    Organic Reagents

    Characteristics
    Density:

    1.111±0.06 g/cm3(Predicted)

    Boiling Point:

    866.2±65.0 °C(Predicted)

    Research
    Class:

    Angiotensin IV-derived oligopeptide / HGF-c-Met potentiator

    Status:

    Research compound — Not FDA approved

    Mechanism:

    A synthetic, orally active, blood-brain-barrier-permeable oligopeptide (Hexanoyl-Tyr-Ile-Ahx-NH₂) derived from angiotensin IV. Dihexa binds hepatocyte growth factor (HGF) with high affinity (Kd = 65 pM) and allosterically potentiates HGF activity at its receptor c-Met, promoting dendritic spinogenesis and synaptogenesis. In preclinical models it was reported to be seven orders of magnitude more potent than BDNF at promoting synapse formation. Note: the foundational 2014 paper (McCoy AT, et al. Neurobiol Learn Mem. 2014) was retracted in 2025.

    EC50 (HGF Binding KD):

    65 pM

    Activity note:

    Dihexa is an HGF potentiator, not a direct receptor agonist. It does not activate c-Met alone but markedly augments HGF-induced c-Met activation at low nanomolar HGF concentrations. Functional synaptogenic activity was reported at 10⁻¹°–10⁻⁻ M (original data now subject to retraction).

    Source:

    Original report: McCoy AT, et al. Neurobiol Learn Mem. 2014;115:112-120 (retracted 2025). Benoist CC, et al. J Pharmacol Exp Ther. 2014;351(3):628-637.

    Clinical Development:

    NCT04488419

    References
    PubChem:

    PubChem

    UNII:

    9WYX65A5C2

    Disclaimer:

    Dihexa is NOT FDA-approved or EMA-approved as a medicine. It is a research compound only. The foundational 2014 paper describing its synaptogenic potency was retracted in 2025. Its phosphate prodrug fosgonimeton failed a Phase 2/3 Alzheimer’s trial (LIFT-AD, 2024). This listing is for industrial and laboratory research use only. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.

  • Seller Information
    Business Type:

    Trader

    Main Products:

    Medetomidine,Medetomidine hydrochloride,D-Lysergic Acid Methyl Ester,SR17018,Fluralaner,GS-441524

    Location:

    RONGSHENG BEIYUANDAJIE 9, LICHENG DISTRICT,JINAN, SHANDONG CHINA

    Payment Terms:

    TT against copy of documents,TT against B/L draft before shipment,100% TT in advance

    Average lead Time:

    7

    Total Annual Revenue:

    $1 million-$2.5 million

    Total Employees:

    11-50

    Year of Establishment:

    2022

    Jinan Topfull Chemical Co., Ltd. is a global chemical Industrial and focuses on advanced chemical technology. Specialized in Cosmetic materials, water treatment, fine chemicals and so on. We are looking forward to working together with the people of all circles at home and abroad to seek common development!
  • Inquiry History
    172 Inquiries
    Country Product Purchase Quantity Date Posted
    Canada

    Dihexa lyophilized 1401708-83-5

    Aug 23, 2026
    Canada

    Dihexa 1401708-83-5

    1 G Mar 8, 2026
    Bulgaria

    Customized peptides high purity Dihexa with fast shipping door to door CAS 1401708-83-5

    10 G May 27, 2025
    United States

    Dihexa

    500 G Aug 19, 2026
    United States

    Dihexa

    25 G Jan 26, 2025
    Russia

    DIHEXA

    50.00 G Aug 14, 2024
    Spain

    Dihexa

    100 MG Aug 30, 2026
    United Arab Emirates

    Diheza

    1 G Aug 28, 2026
    Canada

    Dihexa

    130  Aug 12, 2026
    Brazil

    dihexa

    90 MG Aug 4, 2026
    United States

    Dihexa raw powder

    10 G Jul 26, 2026
    Singapore

    Dihexa

    10 PCS Jul 15, 2026
    United States

    Dihexa

    1 G Jul 11, 2026
    Sweden

    Dihexa

    10 PCS Jul 8, 2026
    Australia

    Dihexa

    1 MT Jul 2, 2026
    United States

    Dihexa

    10 G Jun 14, 2026
    Germany

    Dihexa

    1 G May 25, 2026
    Thailand

    Dihexa

    1 G May 12, 2026
    United States

    Dihexa

    100 G May 4, 2026
    Italy

    simona migliori

    10 MT Apr 23, 2026
    Post an enquiry for this product
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