Anti-Hair-Loss 2,4-Diamino pyrimidine-3-oxide/Kopexil/Unoxidil/Aminexil Cosmetic Ingredient

Description

Diaminopyrimidine oxide (2,4-Diaminopyrimidine-3-oxide, abbreviated as 2,4-DPO), CAS No. 74638-76-9, INCI name Diaminopyrimidine Oxide, molecular formula C₄H₆N₄O, molecular weight 126.12. It is a pyrimidine active ingredient with a structure similar to minoxidil, and also one of the well-established cosmetic raw materials widely used in the field of hair loss prevention and hair care. It has been included in China's Inventory of Existing Cosmetic Ingredients. This product is a high-purity (≥98%, tested by HPLC) white crystalline powder with good water solubility and strong formulation compatibility, which can be conveniently incorporated into various shampoo, conditioner and scalp care products. This product is a cosmetic raw material, not a drug, and cannot replace pharmaceutical treatment.

Key Effects

Diaminopyrimidine Oxide mainly acts on the scalp and the microenvironment around hair follicles, with its core mechanism being to improve the "living conditions" of hair follicles. Research data shows that excessive hardening and fibrosis of collagen tissue around hair follicles can compress hair roots and accelerate follicle degeneration. This ingredient can soften the collagen tissue surrounding hair follicles, ease the fibrotic tendency, and help maintain a healthy growth environment for hair follicles. Meanwhile, as a potassium channel opener, it helps improve local microcirculation of the scalp, delivers better nutritional support to hair roots, and thereby reduces abnormal hair shedding and sustains healthy hair growth.

Specifically, its functions in hair care formulations include:
Reducing hair loss: It targets deep structures of hair follicles to help anchor hair roots and cut down abnormal hair shedding.
Improving follicle environment: Softens collagen tissue around follicles, alleviates fibrotic hardening, and delays follicle degeneration.
Supporting scalp microcirculation: As a potassium channel opener, it helps optimize the local scalp environment and assists nutrient supply to hair roots.
Gentle and formulation-friendly: It boasts good water solubility and requires no alcohol for solubilization, making it suitable for mild, alcohol-free hair care formulations.

Applications

Diaminopyrimidine Oxide is mainly used in the formula development of anti-hair loss hair care cosmetics. It is a common active ingredient in products such as anti-hair loss shampoos and scalp serums, and is widely applied in the domestic and international hair care markets with mature relevant formulation processes and stable supply chains.

Specific application scenarios include:
Anti-hair loss cleansing and care products: rinse-off products such as anti-hair loss shampoos, hair conditioners and hair masks.
Scalp care products: leave-on products such as scalp serums, scalp nourishing liquids and scalp sprays.
Hair growth products: hair products such as hair growth liquids and hair growth emulsions (the addition concentration shall be strictly controlled).
Eyelash / eyebrow care: products like eyelash serums, with a recommended addition level of 0.5%–1.5%.

Formulation recommendation: the maximum permitted concentration in hair products is 1.5% (as required by restricted components in China's Technical Specification for Cosmetic Safety (2015 Edition)). The actual addition amount shall be determined based on the formulation system and target efficacy.